IDEAL List

IDEAL

IID50342
UniprotQ8R4E9
ProteinDNA replication factor Cdt1
GeneCdt1
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf

Structure

Experiment

:order disorder conflict PDB cluster ProS Pfam Domain SEG

557

order/disorder by at least rule

disorder by at least rule

order by at least rule

order/disorder by majority rule

Seq 172-368 Hetero trimer : IID50306Complex

Evidence X-RAY 2zxx F Reference

Region 2zxx F 172-178 disorder

Region 2zxx F 179-291 order

Region 2zxx F 292-294 disorder

Region 2zxx F 295-365 order

Region 2zxx F 366-368 disorder

Evidence X-RAY 2zxx C Reference

Region 2zxx C 172-178 disorder

Region 2zxx C 179-291 order

Region 2zxx C 292-293 disorder

Region 2zxx C 294-365 order

Region 2zxx C 366-368 disorder

Seq 420-557 Monomer :

Evidence NMR 2rqq A Reference

Region 2rqq A 450-557 order

Region 2rqq A 450-451 high_rmsd

Evidence NMR 2klo A Reference

Region 2klo A 420-557 order

Evidence X-RAY 3a4c A Reference

Region 3a4c A 452-557 order

Seqphosphorylation

30-30 Phosphoserine

28-28 Phosphothreonine; by MAPK8

107-107 Phosphoserine; by MAPK8

392-392 Phosphoserine

Prediction

NeProc

Disorder 1-195,291-300,363-462,554-557

Order 196-290,301-362,463-553

ProS 4-13,24-29,135-151,182-188,291-295,367-368,371-381,389-397,427-441,446-457,554-557

AlphaFold

Disorder 1-130,158-178,290-295,366-370,394-428,556-557

Order 131-157,179-289,296-365,371-393,429-555

SEG 41-52 ,59-70 ,72-108 ,401-427 ,454-469

Function

Function in SwissProt

Required for both DNA replication and mitosis. DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC). Required also for mitosis by promoting stable kinetochore-microtubule attachments (By similarity). Potential oncogene (PubMed:11850834).