Search Keyword:


Search option:


IID90004
 UniprotP03211
ProteinEpstein-Barr nuclear antigen 1
GeneEBNA1
OrganismEpstein-Barr virus (strain B95-8)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
641
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 378-386 Hetero trimer : IID50009Complex
 Evidence X-RAY 5wun C Reference
       Region 5wun C 378-383 order
       Region 5wun C 384-386 disorder
 Evidence X-RAY 5wun B Reference
       Region 5wun B 378-382 order
       Region 5wun B 383-386 disorder
 Evidence X-RAY 5wum C Reference
       Region 5wum C 378-383 order
       Region 5wum C 384-386 disorder
 Evidence X-RAY 5wum B Reference
       Region 5wum B 378-385 order
       Region 5wum B 386-386 disorder
Seq 407-417 Hetero trimer : P30685
 Evidence X-RAY 2fz3 C Reference
       Region 2fz3 C 407-417 order
 Evidence X-RAY 2fyy C Reference
       Region 2fyy C 407-410 order
       Region 2fyy C 411-414 disorder
       Region 2fyy C 415-417 order
Seq 441-450 Hetero dimer : IID00176Complex
 Evidence X-RAY 1yy6 B Reference
       Region 1yy6 B 441-448 order
       Region 1yy6 B 449-450 disorder
Seq 461-607 Homo dimer :
 Evidence X-RAY 1vhi B Reference
       Region 1vhi B 466-475 disorder
       Region 1vhi B 476-607 order
 Evidence X-RAY 1vhi A Reference
       Region 1vhi A 466-468 disorder
       Region 1vhi A 469-607 order
 Evidence X-RAY 1b3t B Reference
       Region 1b3t B 461-607 order
 Evidence X-RAY 1b3t A Reference
       Region 1b3t A 461-607 order
Seq 470-619 Homo hexamer :
 Evidence X-RAY 5wmf F Reference
       Region 5wmf F 470-473 disorder
       Region 5wmf F 474-613 order
       Region 5wmf F 614-619 disorder
 Evidence X-RAY 5wmf E Reference
       Region 5wmf E 470-476 disorder
       Region 5wmf E 477-611 order
       Region 5wmf E 612-619 disorder
 Evidence X-RAY 5wmf D Reference
       Region 5wmf D 470-474 disorder
       Region 5wmf D 475-611 order
       Region 5wmf D 612-619 disorder
 Evidence X-RAY 5wmf C Reference
       Region 5wmf C 470-475 disorder
       Region 5wmf C 476-613 order
       Region 5wmf C 614-619 disorder
 Evidence X-RAY 5wmf B Reference
       Region 5wmf B 470-474 disorder
       Region 5wmf B 475-611 order
       Region 5wmf B 612-619 disorder
 Evidence X-RAY 5wmf A Reference
       Region 5wmf A 470-474 disorder
       Region 5wmf A 475-611 order
       Region 5wmf A 612-619 disorder
SeqProS predicted 378-382 The unbound state of this region is predicted to be disordered by DICHOT, FoldIndex and MobiDB. Hetero trimer : IID50009Complex
       Region 5wun B 378-382 order
       Region 5wun C 378-383 order
       Region 5wum B 378-385 order
       Region 5wum C 378-383 order
SeqProS possible 441-448 Mdm2 and p53 bind upon USP7 in the same interface. Hetero dimer : IID00176Complex
       Region 1yy6 B 441-448 order
Seqphosphorylation
    385-385 Phosphoserine
    393-393 Phosphoserine
 
Prediction
NeProc
Disorder 1-401,406-478,619-641
Order 402-405,479-618
ProS 4-17,34-55,66-72,77-93,102-378,406-447,452-478,619-637
AlphaFold
Disorder 1-462,469-471,610-641
Order 463-468,472-609
Pfam Hmmer
PF02905 461-606 1.2e-106
SEG 4-69 ,90-377 ,380-404 ,420-432 ,449-470 ,540-553 ,615-639
Function
Function in SwissProt
Plays an essential role in replication and partitioning of viral genomic DNA during latent viral infection. During this phase, the circular double-stranded viral DNA undergoes replication once per cell cycle and is efficiently partitioned to the daughter cells. EBNA1 activates the initiation of viral DNA replication through binding to specific sites in the viral latent origin of replication, oriP. Additionally, it governs the segregation of viral episomes by mediating their attachment to host cell metaphase chromosomes. Also activates the transcription of several viral latency genes. Finally, it can counteract the stabilization of host p53/TP53 by host USP7, thereby decreasing apoptosis and increasing host cell survival.