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IID90007
 UniprotP06492
ProteinTegument protein VP16
GeneUL48
OrganismHuman herpesvirus 1 (strain 17)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
490
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 47-412 Monomer :
 Evidence X-RAY 16vp A Reference
       Region 16vp A 47-349 order
       Region 16vp A 350-394 disorder
       Region 16vp A 395-402 order
       Region 16vp A 403-412 disorder
Seqdisorder 412-490
 Evidence NMR Reference
       Region 412-490 disorder
Seq 465-490 Hetero dimer : IID00314Complex
 Evidence NMR 2phg B Reference
       Region 2phg B 465-490 order
Seq 465-490 Hetero trimer : IID00306Complex
 Evidence NMR 2phe C Reference
       Region 2phe C 465-490 order
SeqProS verified 465-490 This region is the carboxyl subdomain of the VP16 TAD. It interactes with different partners. Hetero dimer : IID00314Complex
       Region 2phg B 465-490 order
       Region 412-490 disorder
SeqProS verified 465-490 This region is the carboxyl subdomain of the VP16 TAD. It interactes with different partners. Hetero trimer : IID00306Complex
       Region 2phe C 465-490 order
       Region 412-490 disorder
Seqphosphorylation
    353-353 Phosphoserine
    411-411 Phosphoserine
    452-452 Phosphoserine
    18-18 Phosphoserine
 
Prediction
NeProc
Disorder 1-42,195-198,354-394
Order 43-49,57-194,199-312,320-353,395-406,414-430,436-490
ProS 1-15,26-42,195-198,354-394
AlphaFold
Disorder 1-45,352-371,374-394,404-490
Order 46-351,372-373,395-403
Pfam Hmmer
PF02232 26-387 3e-233
SEG 14-28 ,49-58 ,378-393 ,432-451
Function
Function in SwissProt
Transcriptional activator of immediate-early (IE) gene products (alpha genes). Acts as a key activator of lytic infection by initiating the lytic program through the assembly of the transcriptional regulatory VP16-induced complex composed of VP16 and two cellular factors, HCFC1 and POU2F 1. VP16-induced complex represents a regulatory switch: when it is on, it promotes IE-gene expression and thus lytic infection, and when it is off, it limits IE-gene transcription favoring latent infection.
May play a role in the aggregation of tegument proteins around nucleocapsids during virus morphogenesis.