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IID90010
 UniprotP68466
ProteinProtein K7
GeneK7_VACCW
OrganismVaccinia virus (strain Western Reserve)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
149
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-149 Hetero pentamer : IID00232Complex
 Evidence X-RAY 3jrv B Reference
       Region 3jrv B 1-5 disorder
       Region 3jrv B 6-149 order
 Evidence X-RAY 3jrv A Reference
       Region 3jrv A 1-5 disorder
       Region 3jrv A 6-81 order
       Region 3jrv A 82-83 disorder
       Region 3jrv A 84-149 order
Seq 1-149 Monomer :
 Evidence NMR 2k36 A Reference
       Region 2k36 A 1-120 order
       Region 2k36 A 1-5 high_rmsd
       Region 2k36 A 91-92 high_rmsd
       Region 2k36 A 121-126 disorder
       Region 2k36 A 121-126 high_rmsd
       Region 2k36 A 127-149 order
SeqProS verified 121-126 Hetero pentamer : IID00232Complex
       Region 3jrv A 84-149 order
       Region 3jrv B 6-149 order
       Region 2k36 A 121-126 disorder
 
Prediction
NeProc
Disorder 1-4
Order 5-149
AlphaFold
Disorder 1-6,119-121,123-124
Order 7-118,122-122,125-149
Pfam Hmmer
PF06225 14-145 4.4e-57
Function
Function in SwissProt
Bcl-2-like protein which, through its interaction with the DEAD box RNA helicase DDX3X/DDX3, prevents TBK1/IKKepsilon-mediated IRF3 activation. Contributes to virulence by binding to the host TRAF6 and IRAK2 and preventing host NF-kappa-B activation.