Search Keyword:


Search option:


IID90015
 UniprotO73947
ProteinDNA polymerase sliding clamp
Genepcn
OrganismPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
249
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-249 Homo trimer :
 Evidence X-RAY 1ge8 A Reference
       Region 1ge8 A 1-1 disorder
       Region 1ge8 A 2-117 order
       Region 1ge8 A 118-125 disorder
       Region 1ge8 A 126-247 order
       Region 1ge8 A 248-249 disorder
 Evidence X-RAY 5auj A Reference
       Region 5auj A 1-1 disorder
       Region 5auj A 2-120 order
       Region 5auj A 121-127 disorder
       Region 5auj A 128-247 order
       Region 5auj A 248-249 disorder
Seq 1-249 Hetero hexamer : Q9UWR2
 Evidence X-RAY 1isq A Reference
       Region 1isq A 1-1 disorder
       Region 1isq A 2-119 order
       Region 1isq A 120-125 disorder
       Region 1isq A 126-247 order
       Region 1isq A 248-249 disorder
Seq 1-249 Monomer :
 Evidence X-RAY 1iz5 B Reference
       Region 1iz5 B 1-1 disorder
       Region 1iz5 B 2-120 order
       Region 1iz5 B 121-125 disorder
       Region 1iz5 B 126-246 order
       Region 1iz5 B 247-249 disorder
 Evidence X-RAY 1iz5 A Reference
       Region 1iz5 A 1-1 disorder
       Region 1iz5 A 2-120 order
       Region 1iz5 A 121-125 disorder
       Region 1iz5 A 126-246 order
       Region 1iz5 A 247-249 disorder
 Evidence X-RAY 1iz4 A Reference
       Region 1iz4 A 1-1 disorder
       Region 1iz4 A 2-120 order
       Region 1iz4 A 121-125 disorder
       Region 1iz4 A 126-247 order
       Region 1iz4 A 248-249 disorder
Seq 2-249 Hetero dimer : IID90009Complex
 Evidence X-RAY 3a2f B Reference
       Region 3a2f B 2-248 order
       Region 3a2f B 249-249 disorder
SeqProS verified 118-125 Hetero dimer : IID90009Complex
       Region 3a2f B 2-248 order
       Region 1ge8 A 118-125 disorder
 
Prediction
NeProc
Order 1-249
AlphaFold
Disorder 248-249
Order 1-247
Pfam Hmmer
PF00705 1-120 2.5e-09
PF02747 124-246 0.00025
Function
Function in SwissProt
Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. Unlike its eukaryotic paralog, loads on circular DNA without the replication factor C (RFC) clamp loader, although RFC greatly increases loading efficiency. Stimulates the ATPase activity of replication factor C (RFC) in the presence of ssDNA. Stimulates the helicase activity of Hel308 and may alter its substrate specificity.