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IID90016
UniprotP03077
ProteinMiddle T antigen
GeneMT_POVMA
OrganismMurine polyomavirus (strain A2)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
421
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 248-251 Hetero dimer : IID00537Complex
 Evidence X-RAY 1ygu D Reference
       Region 1ygu D 248-251 order
 Evidence X-RAY 1ygu C Reference
       Region 1ygu C 248-251 order
Seqphosphorylation
    257-257 Phosphoserine; by host
    250-250 Phosphotyrosine; by host
    315-315 Phosphotyrosine; by host
    322-322 Phosphotyrosine; by host
 
Prediction
NeProc
Disorder 79-84,209-243,287-314,377-392,416-421
Order 1-78,85-208,244-286,315-329,336-376,393-415
ProS 79-84,209-214,224-243,302-307,377-392,416-421
AlphaFold
Disorder 76-80,162-164,193-368,371-372,375-375,421-421
Order 1-75,81-161,165-192,369-370,373-374,376-420
Pfam Hmmer
PF00226 12-72 5.7e-05
PF02380 91-183 7.5e-61
SEG 10-23 ,236-246 ,271-282 ,302-323 ,335-341 ,386-405
Function
Function in SwissProt
Plays a role in transformation by modulating the activities of cellular proteins involved in control of cell proliferation and by acting as a functional homolog of an activated tyrosine kinase-associated growth-factor receptor. Recruits upon association with host Ppp2/PP2A the Src tyrosine kinase components Src, Yes and Fyn, thereby activating their kinase activity. Activation of Shc1, Pclg1 and p85 mediate signal transduction pathways leading to cell cycle progression and cell division. MT plays also a role in regulation of early and late gene expression and in viral DNA replication.