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IID90022
 UniprotP31818
ProteinProtein Nef
Genenef
OrganismSimian immunodeficiency virus (isolate 1A11)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
263
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 95-235 Hetero tetramer : IID00544Complex
 Evidence X-RAY 3ik5 C Reference
       Region 3ik5 C 95-99 disorder
       Region 3ik5 C 100-181 order
       Region 3ik5 C 182-199 disorder
       Region 3ik5 C 200-234 order
       Region 3ik5 C 235-235 disorder
 Evidence X-RAY 3ik5 A Reference
       Region 3ik5 A 95-99 disorder
       Region 3ik5 A 100-180 order
       Region 3ik5 A 181-196 disorder
       Region 3ik5 A 197-234 order
       Region 3ik5 A 235-235 disorder
 
Prediction
NeProc
Disorder 1-64,71-75,258-263
Order 65-70,76-257
ProS 1-6,13-34,47-64,71-75
AlphaFold
Disorder 1-14,22-104,182-203,259-263
Order 15-21,105-181,204-258
Pfam Hmmer
PF00469 2-235 2.9e-150
SEG 88-96
Function
Function in SwissProt
Seems to play a role in optimizing the host cell environment for viral replication without causing cell death by apoptosis. Enhances virus infectivity and pathogenicity. Probably involved in viral immune evasion mechanisms (By similarity).
In infected CD4(+) T-lymphocytes, down-regulates cell surface expression of CD4, CD28, CD3, and MHC-I or MHC-II molecules.
Interferes with TCR signaling from the cell membrane. Interacts with CD247/TCRZ (TCR zeta chain) and exert potent down-regulation of cell surface TCR/CD3 complexes (By similarity).