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IID90029
 UniprotP12977
ProteinEpstein-Barr nuclear antigen 3
GeneEBNA3
OrganismEpstein-Barr virus (strain B95-8)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
944
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 325-333 Hetero trimer : P30460
 Evidence X-RAY 1m05 E Reference
       Region 1m05 E 325-333 order
 Evidence X-RAY 1m05 F Reference
       Region 1m05 F 325-333 order
Seq 406-414 Hetero trimer : P30464
 Evidence X-RAY 1xr8 C Reference
       Region 1xr8 C 406-414 order
 
Prediction
NeProc
Disorder 1-79,333-944
Order 80-332
ProS 8-17,29-40,68-72,333-333,335-344,365-371,703-709,733-736,808-814,854-862,911-924,929-944
AlphaFold
Disorder 1-234,237-238,241-241,255-256,302-303,305-316,338-944
Order 235-236,239-240,242-254,257-301,304-304,317-337
Pfam Hmmer
PF05009 139-386 1.1e-166
SEG 40-53 ,146-156 ,347-365 ,417-429 ,467-484 ,497-512 ,547-560 ,573-584 ,841-853
Function
Function in SwissProt
Plays an essential role for activation and immortalization of human B-cells. Represses transcription of viral promoters TP1 and Cp through interaction with host RBPJ, and inhibits EBNA2-mediated activation of these promoters. Since Cp is the promoter for all EBNA mRNAs, EBNA3A probably contributes to a negative autoregulatory control loop.