Search Keyword:


Search option:


IID00015
UniprotP04637
ProteinCellular tumor antigen p53
GeneTP53
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
393
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-39 Hetero dimer : IID00070Complex
 Evidence NMR 2k8f B Reference
       Region 2k8f B 1-14 disorder
       Region 2k8f B 1-2 high_rmsd
       Region 2k8f B 15-27 order
       Region 2k8f B 28-39 disorder
       Region 2k8f B 38-39 high_rmsd
Seq 1-61 Monomer : IID50008Complex
 Evidence NMR 5hou A Reference
       Region 5hou A 1-61 order
       Region 5hou A 1-13 high_rmsd
       Region 5hou A 59-61 high_rmsd
Seq 1-93 Hetero dimer : IID00297Complex
 Evidence NMR 2ly4 B Reference
       Region 2ly4 B 1-13 disorder
       Region 2ly4 B 14-60 order
       Region 2ly4 B 14-39 high_rmsd
       Region 2ly4 B 56-60 high_rmsd
       Region 2ly4 B 61-93 disorder
Seqdisorder 1-93
 Evidence NMR Reference
       Region 1-93 disorder
Seq 2-61 Monomer : IID50008Complex
 Evidence NMR 5hpd A Reference
       Region 5hpd A 2-61 order
       Region 5hpd A 2-13 high_rmsd
       Region 5hpd A 59-61 high_rmsd
Seq 13-29 Hetero tetramer : IID50077Complex
 Evidence X-RAY 1ycq B Reference
       Region 1ycq B 13-16 disorder
       Region 1ycq B 17-27 order
       Region 1ycq B 28-29 disorder
Seq 13-61 Hetero dimer : IID50008Complex
 Evidence NMR 2l14 B Reference
       Region 2l14 B 13-61 order
       Region 2l14 B 13-16 high_rmsd
       Region 2l14 B 27-38 high_rmsd
       Region 2l14 B 58-61 high_rmsd
Seq 15-29 Hetero dimer : IID00163Complex
 Evidence X-RAY 1ycr B Reference
       Region 1ycr B 15-16 disorder
       Region 1ycr B 17-29 order
 Evidence X-RAY 4hfz D Reference
       Region 4hfz D 15-16 disorder
       Region 4hfz D 17-27 order
       Region 4hfz D 28-29 disorder
 Evidence X-RAY 4hfz B Reference
       Region 4hfz B 15-16 disorder
       Region 4hfz B 17-27 order
       Region 4hfz B 28-29 disorder
Seq 15-29 Hetero dimer : IID00005Complex
 Evidence NMR 2mwy B Reference
       Region 2mwy B 15-29 order
       Region 2mwy B 15-17 high_rmsd
       Region 2mwy B 29-29 high_rmsd
 Evidence X-RAY 3dab H Reference
       Region 3dab H 15-17 disorder
       Region 3dab H 18-28 order
       Region 3dab H 29-29 disorder
 Evidence X-RAY 3dab F Reference
       Region 3dab F 15-15 disorder
       Region 3dab F 16-27 order
       Region 3dab F 28-29 disorder
 Evidence X-RAY 3dab D Reference
       Region 3dab D 15-16 disorder
       Region 3dab D 17-27 order
       Region 3dab D 28-29 disorder
 Evidence X-RAY 3dab B Reference
       Region 3dab B 15-16 disorder
       Region 3dab B 17-28 order
       Region 3dab B 29-29 disorder
Seq 15-37 Hetero dimer : IID50094Complex
 Evidence X-RAY 2z5t R Reference
       Region 2z5t R 15-16 disorder
       Region 2z5t R 17-27 order
       Region 2z5t R 28-29 disorder
 Evidence X-RAY 2z5t Q Reference
       Region 2z5t Q 15-16 disorder
       Region 2z5t Q 17-27 order
       Region 2z5t Q 28-29 disorder
 Evidence X-RAY 2z5t P Reference
       Region 2z5t P 15-16 disorder
       Region 2z5t P 17-27 order
       Region 2z5t P 28-29 disorder
 Evidence X-RAY 2z5s R Reference
       Region 2z5s R 15-17 disorder
       Region 2z5s R 18-27 order
       Region 2z5s R 28-29 disorder
 Evidence X-RAY 2z5s Q Reference
       Region 2z5s Q 15-16 disorder
       Region 2z5s Q 17-27 order
       Region 2z5s Q 28-29 disorder
 Evidence X-RAY 2z5s P Reference
       Region 2z5s P 15-16 disorder
       Region 2z5s P 17-27 order
       Region 2z5s P 28-29 disorder
 Evidence X-RAY 3dac B Reference
       Region 3dac B 17-29 order
       Region 3dac B 30-37 disorder
 Evidence X-RAY 3dac P Reference
       Region 3dac P 17-28 order
       Region 3dac P 29-37 disorder
Seq 20-73 Hetero dimer : IID50021Complex
 Evidence NMR 2gs0 B Reference
       Region 2gs0 B 20-44 disorder
       Region 2gs0 B 45-58 order
       Region 2gs0 B 58-58 high_rmsd
       Region 2gs0 B 59-73 disorder
Seq 33-60 Hetero hexamer : IID00036Complex
 Evidence X-RAY 2b3g B Reference
       Region 2b3g B 33-56 order
       Region 2b3g B 57-60 disorder
Seq 35-59 Hetero dimer : IID00070Complex
 Evidence NMR 2mzd B Reference
       Region 2mzd B 35-59 order
       Region 2mzd B 35-37 high_rmsd
       Region 2mzd B 59-59 high_rmsd
Seq 37-61 Monomer : IID50008Complex
 Evidence NMR 5hp0 A Reference
       Region 5hp0 A 37-61 order
       Region 5hp0 A 57-61 high_rmsd
Seq 41-62 Hetero dimer : IID00549Complex
 Evidence NMR 2ruk A Reference
       Region 2ruk A 41-62 order
Seq 89-312 Monomer :
 Evidence NMR 2fej A Reference
       Region 2fej A 94-297 order
       Region 2fej A 94-95 high_rmsd
       Region 2fej A 293-297 high_rmsd
 Evidence X-RAY 3zme B Reference
       Region 3zme B 94-94 disorder
       Region 3zme B 95-291 order
       Region 3zme B 292-312 disorder
 Evidence X-RAY 3zme A Reference
       Region 3zme A 94-95 disorder
       Region 3zme A 96-290 order
       Region 3zme A 291-312 disorder
 Evidence X-RAY 2xwr B Reference
       Region 2xwr B 89-90 disorder
       Region 2xwr B 91-290 order
       Region 2xwr B 291-293 disorder
 Evidence X-RAY 2xwr A Reference
       Region 2xwr A 89-90 disorder
       Region 2xwr A 91-289 order
       Region 2xwr A 290-293 disorder
 Evidence X-RAY 2x0w B Reference
       Region 2x0w B 94-96 disorder
       Region 2x0w B 97-290 order
       Region 2x0w B 291-312 disorder
 Evidence X-RAY 2x0w A Reference
       Region 2x0w A 94-95 disorder
       Region 2x0w A 96-290 order
       Region 2x0w A 291-312 disorder
 Evidence X-RAY 2x0v B Reference
       Region 2x0v B 94-94 disorder
       Region 2x0v B 95-289 order
       Region 2x0v B 290-312 disorder
 Evidence X-RAY 2x0v A Reference
       Region 2x0v A 94-95 disorder
       Region 2x0v A 96-220 order
       Region 2x0v A 221-222 disorder
       Region 2x0v A 223-290 order
       Region 2x0v A 291-312 disorder
 Evidence X-RAY 2x0u B Reference
       Region 2x0u B 94-96 disorder
       Region 2x0u B 97-290 order
       Region 2x0u B 291-312 disorder
 Evidence X-RAY 2x0u A Reference
       Region 2x0u A 94-95 disorder
       Region 2x0u A 96-290 order
       Region 2x0u A 291-312 disorder
 Evidence X-RAY 2wgx B Reference
       Region 2wgx B 94-96 disorder
       Region 2wgx B 97-290 order
       Region 2wgx B 291-312 disorder
 Evidence X-RAY 2wgx A Reference
       Region 2wgx A 94-95 disorder
       Region 2wgx A 96-290 order
       Region 2wgx A 291-312 disorder
 Evidence X-RAY 2vuk B Reference
       Region 2vuk B 94-94 disorder
       Region 2vuk B 95-290 order
       Region 2vuk B 291-312 disorder
 Evidence X-RAY 2vuk A Reference
       Region 2vuk A 94-95 disorder
       Region 2vuk A 96-290 order
       Region 2vuk A 291-312 disorder
 Evidence X-RAY 1uol B Reference
       Region 1uol B 94-95 disorder
       Region 1uol B 96-290 order
       Region 1uol B 291-312 disorder
 Evidence X-RAY 1uol A Reference
       Region 1uol A 94-95 disorder
       Region 1uol A 96-290 order
       Region 1uol A 291-312 disorder
 Evidence X-RAY 2pcx A Reference
       Region 2pcx A 94-292 order
 Evidence X-RAY 2ocj D Reference
       Region 2ocj D 94-95 disorder
       Region 2ocj D 96-289 order
       Region 2ocj D 290-312 disorder
 Evidence X-RAY 2ocj C Reference
       Region 2ocj C 94-95 disorder
       Region 2ocj C 96-289 order
       Region 2ocj C 290-312 disorder
 Evidence X-RAY 2ocj B Reference
       Region 2ocj B 94-95 disorder
       Region 2ocj B 96-289 order
       Region 2ocj B 290-312 disorder
 Evidence X-RAY 2ocj A Reference
       Region 2ocj A 94-95 disorder
       Region 2ocj A 96-289 order
       Region 2ocj A 290-312 disorder
 Evidence X-RAY 4mzi A Reference
       Region 4mzi A 94-95 disorder
       Region 4mzi A 96-288 order
       Region 4mzi A 289-292 disorder
 Evidence X-RAY 4lof A Reference
       Region 4lof A 94-291 order
       Region 4lof A 292-312 disorder
 Evidence X-RAY 4loe D Reference
       Region 4loe D 94-95 disorder
       Region 4loe D 96-289 order
       Region 4loe D 290-312 disorder
 Evidence X-RAY 4loe C Reference
       Region 4loe C 94-95 disorder
       Region 4loe C 96-289 order
       Region 4loe C 290-312 disorder
 Evidence X-RAY 4loe B Reference
       Region 4loe B 94-95 disorder
       Region 4loe B 96-289 order
       Region 4loe B 290-312 disorder
 Evidence X-RAY 4loe A Reference
       Region 4loe A 94-95 disorder
       Region 4loe A 96-289 order
       Region 4loe A 290-312 disorder
 Evidence X-RAY 4lo9 D Reference
       Region 4lo9 D 94-95 disorder
       Region 4lo9 D 96-289 order
       Region 4lo9 D 290-312 disorder
 Evidence X-RAY 4lo9 C Reference
       Region 4lo9 C 94-95 disorder
       Region 4lo9 C 96-289 order
       Region 4lo9 C 290-312 disorder
 Evidence X-RAY 4lo9 B Reference
       Region 4lo9 B 94-95 disorder
       Region 4lo9 B 96-289 order
       Region 4lo9 B 290-312 disorder
 Evidence X-RAY 4lo9 A Reference
       Region 4lo9 A 94-95 disorder
       Region 4lo9 A 96-289 order
       Region 4lo9 A 290-312 disorder
 Evidence X-RAY 5lap B Reference
       Region 5lap B 94-94 disorder
       Region 5lap B 95-290 order
       Region 5lap B 291-312 disorder
 Evidence X-RAY 5lap A Reference
       Region 5lap A 94-95 disorder
       Region 5lap A 96-290 order
       Region 5lap A 291-312 disorder
 Evidence X-RAY 4kvp D Reference
       Region 4kvp D 94-95 disorder
       Region 4kvp D 96-289 order
       Region 4kvp D 290-312 disorder
 Evidence X-RAY 4kvp C Reference
       Region 4kvp C 94-94 disorder
       Region 4kvp C 95-289 order
       Region 4kvp C 290-312 disorder
 Evidence X-RAY 4kvp B Reference
       Region 4kvp B 94-95 disorder
       Region 4kvp B 96-289 order
       Region 4kvp B 290-312 disorder
 Evidence X-RAY 4kvp A Reference
       Region 4kvp A 94-95 disorder
       Region 4kvp A 96-289 order
       Region 4kvp A 290-312 disorder
 Evidence X-RAY 2j21 B Reference
       Region 2j21 B 94-95 disorder
       Region 2j21 B 96-115 order
       Region 2j21 B 116-121 disorder
       Region 2j21 B 122-289 order
       Region 2j21 B 290-312 disorder
 Evidence X-RAY 2j21 A Reference
       Region 2j21 A 94-95 disorder
       Region 2j21 A 96-116 order
       Region 2j21 A 117-121 disorder
       Region 2j21 A 122-288 order
       Region 2j21 A 289-312 disorder
 Evidence X-RAY 2j20 B Reference
       Region 2j20 B 94-96 disorder
       Region 2j20 B 97-290 order
       Region 2j20 B 291-312 disorder
 Evidence X-RAY 2j20 A Reference
       Region 2j20 A 94-95 disorder
       Region 2j20 A 96-290 order
       Region 2j20 A 291-312 disorder
 Evidence X-RAY 2j1z B Reference
       Region 2j1z B 94-95 disorder
       Region 2j1z B 96-290 order
       Region 2j1z B 291-312 disorder
 Evidence X-RAY 2j1z A Reference
       Region 2j1z A 94-95 disorder
       Region 2j1z A 96-290 order
       Region 2j1z A 291-312 disorder
 Evidence X-RAY 2j1y D Reference
       Region 2j1y D 94-95 disorder
       Region 2j1y D 96-182 order
       Region 2j1y D 183-184 disorder
       Region 2j1y D 185-289 order
       Region 2j1y D 290-293 disorder
 Evidence X-RAY 2j1y C Reference
       Region 2j1y C 94-95 disorder
       Region 2j1y C 96-181 order
       Region 2j1y C 182-184 disorder
       Region 2j1y C 185-289 order
       Region 2j1y C 290-293 disorder
 Evidence X-RAY 2j1y B Reference
       Region 2j1y B 94-95 disorder
       Region 2j1y B 96-183 order
       Region 2j1y B 184-184 disorder
       Region 2j1y B 185-289 order
       Region 2j1y B 290-293 disorder
 Evidence X-RAY 2j1y A Reference
       Region 2j1y A 94-94 disorder
       Region 2j1y A 95-181 order
       Region 2j1y A 182-184 disorder
       Region 2j1y A 185-289 order
       Region 2j1y A 290-293 disorder
 Evidence X-RAY 2j1x B Reference
       Region 2j1x B 94-96 disorder
       Region 2j1x B 97-291 order
       Region 2j1x B 292-312 disorder
 Evidence X-RAY 2j1x A Reference
       Region 2j1x A 94-95 disorder
       Region 2j1x A 96-290 order
       Region 2j1x A 291-312 disorder
 Evidence X-RAY 2j1w B Reference
       Region 2j1w B 94-95 disorder
       Region 2j1w B 96-290 order
       Region 2j1w B 291-312 disorder
 Evidence X-RAY 2j1w A Reference
       Region 2j1w A 94-95 disorder
       Region 2j1w A 96-290 order
       Region 2j1w A 291-312 disorder
 Evidence X-RAY 4ijt A Reference
       Region 4ijt A 94-291 order
       Region 4ijt A 292-293 disorder
 Evidence X-RAY 4ibz D Reference
       Region 4ibz D 94-95 disorder
       Region 4ibz D 96-225 order
       Region 4ibz D 226-226 disorder
       Region 4ibz D 227-288 order
       Region 4ibz D 289-293 disorder
 Evidence X-RAY 4ibz C Reference
       Region 4ibz C 94-95 disorder
       Region 4ibz C 96-182 order
       Region 4ibz C 183-184 disorder
       Region 4ibz C 185-289 order
       Region 4ibz C 290-293 disorder
 Evidence X-RAY 4ibz B Reference
       Region 4ibz B 94-96 disorder
       Region 4ibz B 97-288 order
       Region 4ibz B 289-293 disorder
 Evidence X-RAY 4ibz A Reference
       Region 4ibz A 94-95 disorder
       Region 4ibz A 96-288 order
       Region 4ibz A 289-293 disorder
 Evidence X-RAY 4iby B Reference
       Region 4iby B 94-289 order
       Region 4iby B 290-293 disorder
 Evidence X-RAY 4iby A Reference
       Region 4iby A 94-290 order
       Region 4iby A 291-293 disorder
 Evidence X-RAY 4ibt D Reference
       Region 4ibt D 94-94 disorder
       Region 4ibt D 95-289 order
       Region 4ibt D 290-293 disorder
 Evidence X-RAY 4ibt C Reference
       Region 4ibt C 94-290 order
       Region 4ibt C 291-293 disorder
 Evidence X-RAY 4ibt B Reference
       Region 4ibt B 94-94 disorder
       Region 4ibt B 95-289 order
       Region 4ibt B 290-293 disorder
 Evidence X-RAY 4ibt A Reference
       Region 4ibt A 94-94 disorder
       Region 4ibt A 95-290 order
       Region 4ibt A 291-293 disorder
 Evidence X-RAY 4ibs D Reference
       Region 4ibs D 94-95 disorder
       Region 4ibs D 96-289 order
       Region 4ibs D 290-293 disorder
 Evidence X-RAY 4ibs C Reference
       Region 4ibs C 94-95 disorder
       Region 4ibs C 96-289 order
       Region 4ibs C 290-293 disorder
 Evidence X-RAY 4ibs B Reference
       Region 4ibs B 94-95 disorder
       Region 4ibs B 96-289 order
       Region 4ibs B 290-293 disorder
 Evidence X-RAY 4ibs A Reference
       Region 4ibs A 94-95 disorder
       Region 4ibs A 96-288 order
       Region 4ibs A 289-293 disorder
 Evidence X-RAY 4ibq D Reference
       Region 4ibq D 94-95 disorder
       Region 4ibq D 96-288 order
       Region 4ibq D 289-293 disorder
 Evidence X-RAY 4ibq C Reference
       Region 4ibq C 94-96 disorder
       Region 4ibq C 97-288 order
       Region 4ibq C 289-293 disorder
 Evidence X-RAY 4ibq B Reference
       Region 4ibq B 94-95 disorder
       Region 4ibq B 96-288 order
       Region 4ibq B 289-293 disorder
 Evidence X-RAY 4ibq A Reference
       Region 4ibq A 94-96 disorder
       Region 4ibq A 97-288 order
       Region 4ibq A 289-293 disorder
 Evidence X-RAY 3d09 A Reference
       Region 3d09 A 94-95 disorder
       Region 3d09 A 96-116 order
       Region 3d09 A 117-121 disorder
       Region 3d09 A 122-182 order
       Region 3d09 A 183-184 disorder
       Region 3d09 A 185-290 order
       Region 3d09 A 291-293 disorder
 Evidence X-RAY 3d08 A Reference
       Region 3d08 A 94-96 disorder
       Region 3d08 A 97-116 order
       Region 3d08 A 117-121 disorder
       Region 3d08 A 122-182 order
       Region 3d08 A 183-186 disorder
       Region 3d08 A 187-287 order
       Region 3d08 A 288-293 disorder
 Evidence X-RAY 3d07 B Reference
       Region 3d07 B 94-94 disorder
       Region 3d07 B 95-247 order
       Region 3d07 B 248-248 disorder
       Region 3d07 B 249-292 order
       Region 3d07 B 293-293 disorder
 Evidence X-RAY 3d07 A Reference
       Region 3d07 A 94-246 order
       Region 3d07 A 247-247 disorder
       Region 3d07 A 248-288 order
       Region 3d07 A 289-293 disorder
 Evidence X-RAY 3d06 A Reference
       Region 3d06 A 94-96 disorder
       Region 3d06 A 97-114 order
       Region 3d06 A 115-121 disorder
       Region 3d06 A 122-181 order
       Region 3d06 A 182-187 disorder
       Region 3d06 A 188-288 order
       Region 3d06 A 289-293 disorder
 Evidence X-RAY 3d05 A Reference
       Region 3d05 A 94-95 disorder
       Region 3d05 A 96-114 order
       Region 3d05 A 115-121 disorder
       Region 3d05 A 122-181 order
       Region 3d05 A 182-184 disorder
       Region 3d05 A 185-288 order
       Region 3d05 A 289-293 disorder
 Evidence X-RAY 2biq A Reference
       Region 2biq A 94-95 disorder
       Region 2biq A 96-114 order
       Region 2biq A 115-120 disorder
       Region 2biq A 121-182 order
       Region 2biq A 183-184 disorder
       Region 2biq A 185-242 order
       Region 2biq A 243-244 disorder
       Region 2biq A 245-290 order
       Region 2biq A 291-312 disorder
 Evidence X-RAY 2bip A Reference
       Region 2bip A 94-95 disorder
       Region 2bip A 96-114 order
       Region 2bip A 115-120 disorder
       Region 2bip A 121-182 order
       Region 2bip A 183-184 disorder
       Region 2bip A 185-242 order
       Region 2bip A 243-244 disorder
       Region 2bip A 245-290 order
       Region 2bip A 291-312 disorder
 Evidence X-RAY 2bio A Reference
       Region 2bio A 94-96 disorder
       Region 2bio A 97-116 order
       Region 2bio A 117-120 disorder
       Region 2bio A 121-181 order
       Region 2bio A 182-185 disorder
       Region 2bio A 186-290 order
       Region 2bio A 291-312 disorder
 Evidence X-RAY 2bin A Reference
       Region 2bin A 94-96 disorder
       Region 2bin A 97-116 order
       Region 2bin A 117-120 disorder
       Region 2bin A 121-165 order
       Region 2bin A 166-170 disorder
       Region 2bin A 171-181 order
       Region 2bin A 182-184 disorder
       Region 2bin A 185-291 order
       Region 2bin A 292-312 disorder
 Evidence X-RAY 2bim B Reference
       Region 2bim B 94-95 disorder
       Region 2bim B 96-290 order
       Region 2bim B 291-312 disorder
 Evidence X-RAY 2bim A Reference
       Region 2bim A 94-95 disorder
       Region 2bim A 96-290 order
       Region 2bim A 291-312 disorder
 Evidence X-RAY 5aom B Reference
       Region 5aom B 94-94 disorder
       Region 5aom B 95-289 order
       Region 5aom B 290-312 disorder
 Evidence X-RAY 5aom A Reference
       Region 5aom A 94-95 disorder
       Region 5aom A 96-290 order
       Region 5aom A 291-312 disorder
 Evidence X-RAY 5aol B Reference
       Region 5aol B 94-290 order
       Region 5aol B 291-312 disorder
 Evidence X-RAY 5aol A Reference
       Region 5aol A 94-95 disorder
       Region 5aol A 96-292 order
       Region 5aol A 293-312 disorder
 Evidence X-RAY 5aok B Reference
       Region 5aok B 94-291 order
       Region 5aok B 292-312 disorder
 Evidence X-RAY 5aok A Reference
       Region 5aok A 94-95 disorder
       Region 5aok A 96-290 order
       Region 5aok A 291-312 disorder
 Evidence X-RAY 5aoj B Reference
       Region 5aoj B 94-290 order
       Region 5aoj B 291-312 disorder
 Evidence X-RAY 5aoj A Reference
       Region 5aoj A 94-95 disorder
       Region 5aoj A 96-290 order
       Region 5aoj A 291-312 disorder
 Evidence X-RAY 5aoi B Reference
       Region 5aoi B 94-94 disorder
       Region 5aoi B 95-290 order
       Region 5aoi B 291-312 disorder
 Evidence X-RAY 5aoi A Reference
       Region 5aoi A 94-95 disorder
       Region 5aoi A 96-290 order
       Region 5aoi A 291-312 disorder
 Evidence X-RAY 4agq B Reference
       Region 4agq B 94-289 order
       Region 4agq B 290-312 disorder
 Evidence X-RAY 4agq A Reference
       Region 4agq A 94-95 disorder
       Region 4agq A 96-290 order
       Region 4agq A 291-312 disorder
 Evidence X-RAY 4agp B Reference
       Region 4agp B 94-290 order
       Region 4agp B 291-312 disorder
 Evidence X-RAY 4agp A Reference
       Region 4agp A 94-95 disorder
       Region 4agp A 96-291 order
       Region 4agp A 292-312 disorder
 Evidence X-RAY 4ago B Reference
       Region 4ago B 94-289 order
       Region 4ago B 290-312 disorder
 Evidence X-RAY 4ago A Reference
       Region 4ago A 94-95 disorder
       Region 4ago A 96-291 order
       Region 4ago A 292-312 disorder
 Evidence X-RAY 4agn B Reference
       Region 4agn B 94-290 order
       Region 4agn B 291-312 disorder
 Evidence X-RAY 4agn A Reference
       Region 4agn A 94-95 disorder
       Region 4agn A 96-292 order
       Region 4agn A 293-312 disorder
 Evidence X-RAY 4agl B Reference
       Region 4agl B 94-290 order
       Region 4agl B 291-312 disorder
 Evidence X-RAY 4agl A Reference
       Region 4agl A 94-95 disorder
       Region 4agl A 96-290 order
       Region 4agl A 291-312 disorder
 Evidence X-RAY 5aba B Reference
       Region 5aba B 94-290 order
       Region 5aba B 291-312 disorder
 Evidence X-RAY 5aba A Reference
       Region 5aba A 94-95 disorder
       Region 5aba A 96-290 order
       Region 5aba A 291-312 disorder
 Evidence X-RAY 5ab9 B Reference
       Region 5ab9 B 94-94 disorder
       Region 5ab9 B 95-291 order
       Region 5ab9 B 292-312 disorder
 Evidence X-RAY 5ab9 A Reference
       Region 5ab9 A 94-95 disorder
       Region 5ab9 A 96-290 order
       Region 5ab9 A 291-312 disorder
 Evidence X-RAY 5a7b B Reference
       Region 5a7b B 94-290 order
       Region 5a7b B 291-312 disorder
 Evidence X-RAY 5a7b A Reference
       Region 5a7b A 94-95 disorder
       Region 5a7b A 96-291 order
       Region 5a7b A 292-312 disorder
Seq 92-292 Hetero dodecamer : IID90002Complex
 Evidence X-RAY 2h1l X Reference
       Region 2h1l X 92-289 order
       Region 2h1l X 290-292 disorder
 Evidence X-RAY 2h1l W Reference
       Region 2h1l W 92-289 order
       Region 2h1l W 290-292 disorder
 Evidence X-RAY 2h1l V Reference
       Region 2h1l V 92-289 order
       Region 2h1l V 290-292 disorder
 Evidence X-RAY 2h1l U Reference
       Region 2h1l U 92-289 order
       Region 2h1l U 290-292 disorder
 Evidence X-RAY 2h1l T Reference
       Region 2h1l T 92-289 order
       Region 2h1l T 290-292 disorder
 Evidence X-RAY 2h1l S Reference
       Region 2h1l S 92-289 order
       Region 2h1l S 290-292 disorder
 Evidence X-RAY 2h1l R Reference
       Region 2h1l R 92-289 order
       Region 2h1l R 290-292 disorder
 Evidence X-RAY 2h1l Q Reference
       Region 2h1l Q 92-289 order
       Region 2h1l Q 290-292 disorder
 Evidence X-RAY 2h1l P Reference
       Region 2h1l P 92-289 order
       Region 2h1l P 290-292 disorder
 Evidence X-RAY 2h1l O Reference
       Region 2h1l O 92-289 order
       Region 2h1l O 290-292 disorder
 Evidence X-RAY 2h1l N Reference
       Region 2h1l N 92-289 order
       Region 2h1l N 290-292 disorder
 Evidence X-RAY 2h1l M Reference
       Region 2h1l M 92-289 order
       Region 2h1l M 290-292 disorder
Seq 92-312 Hetero dimer :
 Evidence X-RAY 4qo1 B Reference
       Region 4qo1 B 92-290 order
       Region 4qo1 B 291-312 disorder
Seq 92-293,319-358 Homo tetramer :
 Evidence X-RAY 3ts8 D Reference
       Region 3ts8 D 94-290 order
       Region 3ts8 D 320-356 order
 Evidence X-RAY 3ts8 C Reference
       Region 3ts8 C 94-290 order
       Region 3ts8 C 320-356 order
 Evidence X-RAY 3ts8 B Reference
       Region 3ts8 B 94-290 order
       Region 3ts8 B 320-356 order
 Evidence X-RAY 3ts8 A Reference
       Region 3ts8 A 94-290 order
       Region 3ts8 A 320-356 order
 Evidence X-RAY 3q06 D Reference
       Region 3q06 D 96-290 order
       Region 3q06 D 319-354 order
 Evidence X-RAY 3q06 C Reference
       Region 3q06 C 96-290 order
       Region 3q06 C 319-354 order
 Evidence X-RAY 3q06 B Reference
       Region 3q06 B 96-290 order
       Region 3q06 B 319-354 order
 Evidence X-RAY 3q06 A Reference
       Region 3q06 A 96-290 order
       Region 3q06 A 319-354 order
 Evidence X-RAY 3q05 D Reference
       Region 3q05 D 94-290 order
       Region 3q05 D 320-356 order
 Evidence X-RAY 3q05 C Reference
       Region 3q05 C 94-290 order
       Region 3q05 C 320-356 order
 Evidence X-RAY 3q05 B Reference
       Region 3q05 B 94-290 order
       Region 3q05 B 320-356 order
 Evidence X-RAY 3q05 A Reference
       Region 3q05 A 94-290 order
       Region 3q05 A 320-356 order
 Evidence X-RAY 4mzr D Reference
       Region 4mzr D 94-290 order
       Region 4mzr D 320-356 order
       Region 4mzr D 357-358 disorder
 Evidence X-RAY 4mzr C Reference
       Region 4mzr C 94-290 order
       Region 4mzr C 320-356 order
       Region 4mzr C 357-358 disorder
 Evidence X-RAY 4mzr B Reference
       Region 4mzr B 94-290 order
       Region 4mzr B 320-356 order
       Region 4mzr B 357-358 disorder
 Evidence X-RAY 4mzr A Reference
       Region 4mzr A 94-290 order
       Region 4mzr A 320-356 order
       Region 4mzr A 357-358 disorder
 Evidence X-RAY 5lgy D Reference
       Region 5lgy D 94-94 disorder
       Region 5lgy D 95-291 order
 Evidence X-RAY 5lgy C Reference
       Region 5lgy C 94-94 disorder
       Region 5lgy C 95-291 order
 Evidence X-RAY 5lgy B Reference
       Region 5lgy B 94-291 order
 Evidence X-RAY 5lgy A Reference
       Region 5lgy A 94-94 disorder
       Region 5lgy A 95-291 order
 Evidence X-RAY 3kz8 B Reference
       Region 3kz8 B 94-94 disorder
       Region 3kz8 B 95-184 order
       Region 3kz8 B 185-187 disorder
       Region 3kz8 B 188-292 order
       Region 3kz8 B 293-293 disorder
 Evidence X-RAY 3kz8 A Reference
       Region 3kz8 A 94-94 disorder
       Region 3kz8 A 95-184 order
       Region 3kz8 A 185-187 disorder
       Region 3kz8 A 188-292 order
       Region 3kz8 A 293-293 disorder
 Evidence X-RAY 3kmd D Reference
       Region 3kmd D 92-291 order
 Evidence X-RAY 3kmd C Reference
       Region 3kmd C 92-291 order
 Evidence X-RAY 3kmd B Reference
       Region 3kmd B 92-291 order
 Evidence X-RAY 3kmd A Reference
       Region 3kmd A 92-291 order
 Evidence X-RAY 4ibu D Reference
       Region 4ibu D 94-94 disorder
       Region 4ibu D 95-290 order
       Region 4ibu D 291-293 disorder
 Evidence X-RAY 4ibu C Reference
       Region 4ibu C 94-95 disorder
       Region 4ibu C 96-290 order
       Region 4ibu C 291-293 disorder
 Evidence X-RAY 4ibu B Reference
       Region 4ibu B 94-291 order
       Region 4ibu B 292-293 disorder
 Evidence X-RAY 4ibu A Reference
       Region 4ibu A 94-95 disorder
       Region 4ibu A 96-292 order
       Region 4ibu A 293-293 disorder
 Evidence X-RAY 4hje D Reference
       Region 4hje D 92-291 order
 Evidence X-RAY 4hje C Reference
       Region 4hje C 92-291 order
 Evidence X-RAY 4hje B Reference
       Region 4hje B 92-291 order
 Evidence X-RAY 4hje A Reference
       Region 4hje A 92-291 order
 Evidence X-RAY 2ata D Reference
       Region 2ata D 94-290 order
       Region 2ata D 291-293 disorder
 Evidence X-RAY 2ata C Reference
       Region 2ata C 94-95 disorder
       Region 2ata C 96-290 order
       Region 2ata C 291-293 disorder
 Evidence X-RAY 2ata B Reference
       Region 2ata B 94-291 order
       Region 2ata B 292-293 disorder
 Evidence X-RAY 2ata A Reference
       Region 2ata A 94-95 disorder
       Region 2ata A 96-292 order
       Region 2ata A 293-293 disorder
 Evidence X-RAY 2ahi D Reference
       Region 2ahi D 94-95 disorder
       Region 2ahi D 96-291 order
       Region 2ahi D 292-293 disorder
 Evidence X-RAY 2ahi C Reference
       Region 2ahi C 94-95 disorder
       Region 2ahi C 96-288 order
       Region 2ahi C 289-293 disorder
 Evidence X-RAY 2ahi B Reference
       Region 2ahi B 94-291 order
       Region 2ahi B 292-293 disorder
 Evidence X-RAY 2ahi A Reference
       Region 2ahi A 94-94 disorder
       Region 2ahi A 95-292 order
       Region 2ahi A 293-293 disorder
 Evidence X-RAY 2ady B Reference
       Region 2ady B 94-291 order
       Region 2ady B 292-293 disorder
 Evidence X-RAY 2ady A Reference
       Region 2ady A 94-94 disorder
       Region 2ady A 95-291 order
       Region 2ady A 292-293 disorder
 Evidence X-RAY 2ac0 D Reference
       Region 2ac0 D 94-95 disorder
       Region 2ac0 D 96-293 order
 Evidence X-RAY 2ac0 C Reference
       Region 2ac0 C 94-95 disorder
       Region 2ac0 C 96-290 order
       Region 2ac0 C 291-293 disorder
 Evidence X-RAY 2ac0 B Reference
       Region 2ac0 B 94-291 order
       Region 2ac0 B 292-293 disorder
 Evidence X-RAY 2ac0 A Reference
       Region 2ac0 A 94-291 order
       Region 2ac0 A 292-293 disorder
Seq 94-292 Hetero trimer : IID00209Complex,IID90005Complex,IID90020Complex
 Evidence X-RAY 4xr8 D Reference
       Region 4xr8 D 94-292 order
Seq 94-292 Hetero trimer : IID00209Complex,IID90005Complex,IID90020Complex
 Evidence X-RAY 4xr8 C Reference
       Region 4xr8 C 94-292 order
Seq 94-292 Hetero dimer : IID00124Complex
 Evidence X-RAY 1ycs A Reference
       Region 1ycs A 94-96 disorder
       Region 1ycs A 97-287 order
       Region 1ycs A 288-292 disorder
Seq 94-293 Homo tetramer :
 Evidence X-RAY 2ybg A Reference
       Region 2ybg A 94-95 disorder
       Region 2ybg A 96-225 order
       Region 2ybg A 226-226 disorder
       Region 2ybg A 227-288 order
       Region 2ybg A 289-293 disorder
 Evidence X-RAY 2ybg B Reference
       Region 2ybg B 94-95 disorder
       Region 2ybg B 96-288 order
       Region 2ybg B 289-293 disorder
 Evidence X-RAY 2ybg C Reference
       Region 2ybg C 94-95 disorder
       Region 2ybg C 96-289 order
       Region 2ybg C 290-293 disorder
 Evidence X-RAY 2ybg D Reference
       Region 2ybg D 94-95 disorder
       Region 2ybg D 96-289 order
       Region 2ybg D 290-293 disorder
Seq 94-312 Homo trimer :
 Evidence X-RAY 1tup C Reference
       Region 1tup C 94-94 disorder
       Region 1tup C 95-289 order
       Region 1tup C 290-312 disorder
 Evidence X-RAY 1tup B Reference
       Region 1tup B 94-95 disorder
       Region 1tup B 96-289 order
       Region 1tup B 290-312 disorder
 Evidence X-RAY 1tup A Reference
       Region 1tup A 94-289 order
       Region 1tup A 290-312 disorder
 Evidence X-RAY 1tsr C Reference
       Region 1tsr C 94-94 disorder
       Region 1tsr C 95-289 order
       Region 1tsr C 290-312 disorder
 Evidence X-RAY 1tsr B Reference
       Region 1tsr B 94-95 disorder
       Region 1tsr B 96-289 order
       Region 1tsr B 290-312 disorder
 Evidence X-RAY 1tsr A Reference
       Region 1tsr A 94-289 order
       Region 1tsr A 290-312 disorder
Seq 94-312,321-356 Homo dimer :
 Evidence X-RAY 5g4o B Reference
       Region 5g4o B 94-290 order
       Region 5g4o B 291-312 disorder
 Evidence X-RAY 5g4o A Reference
       Region 5g4o A 94-95 disorder
       Region 5g4o A 96-291 order
       Region 5g4o A 292-312 disorder
 Evidence X-RAY 5g4n B Reference
       Region 5g4n B 94-290 order
       Region 5g4n B 291-312 disorder
 Evidence X-RAY 5g4n A Reference
       Region 5g4n A 94-95 disorder
       Region 5g4n A 96-291 order
       Region 5g4n A 292-312 disorder
 Evidence X-RAY 5g4m B Reference
       Region 5g4m B 94-290 order
       Region 5g4m B 291-312 disorder
 Evidence X-RAY 5g4m A Reference
       Region 5g4m A 94-95 disorder
       Region 5g4m A 96-290 order
       Region 5g4m A 291-312 disorder
 Evidence X-RAY 4agm B Reference
       Region 4agm B 94-291 order
       Region 4agm B 292-312 disorder
 Evidence X-RAY 4agm A Reference
       Region 4agm A 94-95 disorder
       Region 4agm A 96-292 order
       Region 4agm A 293-312 disorder
 Evidence X-RAY 3q01 B Reference
       Region 3q01 B 94-290 order
       Region 3q01 B 321-356 order
 Evidence X-RAY 3q01 A Reference
       Region 3q01 A 94-290 order
       Region 3q01 A 321-356 order
 Evidence X-RAY 3igl A Reference
       Region 3igl A 94-183 order
       Region 3igl A 184-186 disorder
       Region 3igl A 187-293 order
 Evidence X-RAY 3igk A Reference
       Region 3igk A 94-183 order
       Region 3igk A 184-186 disorder
       Region 3igk A 187-293 order
 Evidence X-RAY 4ibw A Reference
       Region 4ibw A 94-182 order
       Region 4ibw A 183-185 disorder
       Region 4ibw A 186-293 order
 Evidence X-RAY 4ibv A Reference
       Region 4ibv A 94-183 order
       Region 4ibv A 184-186 disorder
       Region 4ibv A 187-293 order
 Evidence X-RAY 3d0a D Reference
       Region 3d0a D 94-94 disorder
       Region 3d0a D 95-288 order
       Region 3d0a D 289-293 disorder
 Evidence X-RAY 3d0a C Reference
       Region 3d0a C 94-95 disorder
       Region 3d0a C 96-288 order
       Region 3d0a C 289-293 disorder
 Evidence X-RAY 3d0a B Reference
       Region 3d0a B 94-94 disorder
       Region 3d0a B 95-291 order
       Region 3d0a B 292-293 disorder
 Evidence X-RAY 3d0a A Reference
       Region 3d0a A 94-95 disorder
       Region 3d0a A 96-291 order
       Region 3d0a A 292-293 disorder
 Evidence X-RAY 5bua A Reference
       Region 5bua A 94-293 order
Seq 95-289 Hetero tetramer : IID00123Complex
 Evidence X-RAY 1kzy B Reference
       Region 1kzy B 95-289 order
 Evidence X-RAY 1kzy A Reference
       Region 1kzy A 95-289 order
Seq 95-312 Hetero dimer : IID00123Complex
 Evidence X-RAY 1gzh C Reference
       Region 1gzh C 95-289 order
       Region 1gzh C 290-292 disorder
 Evidence X-RAY 1gzh A Reference
       Region 1gzh A 95-182 order
       Region 1gzh A 183-188 disorder
       Region 1gzh A 189-199 order
       Region 1gzh A 200-200 disorder
       Region 1gzh A 201-223 order
       Region 1gzh A 224-227 disorder
       Region 1gzh A 228-292 order
 Evidence X-RAY 5ecg B Reference
       Region 5ecg B 95-95 disorder
       Region 5ecg B 96-114 order
       Region 5ecg B 115-121 disorder
       Region 5ecg B 122-182 order
       Region 5ecg B 183-186 disorder
       Region 5ecg B 187-289 order
       Region 5ecg B 290-312 disorder
 Evidence X-RAY 5ecg A Reference
       Region 5ecg A 95-95 disorder
       Region 5ecg A 96-116 order
       Region 5ecg A 117-120 disorder
       Region 5ecg A 121-182 order
       Region 5ecg A 183-184 disorder
       Region 5ecg A 185-293 order
       Region 5ecg A 294-312 disorder
Seq 96-312 Hetero dimer : IID00720Complex
 Evidence NMR 2mej B Reference
       Region 2mej B 96-290 order
       Region 2mej B 291-312 disorder
Seq 144-154 Hetero tetramer : IID00643Complex
 Evidence X-RAY 5un8 E Reference
       Region 5un8 E 144-145 disorder
       Region 5un8 E 146-152 order
       Region 5un8 E 153-154 disorder
 Evidence X-RAY 5un8 G Reference
       Region 5un8 G 144-145 disorder
       Region 5un8 G 146-154 order
Seq 144-154 Hetero tetramer : IID00643Complex
 Evidence X-RAY 5un8 F Reference
       Region 5un8 F 144-145 disorder
       Region 5un8 F 146-153 order
       Region 5un8 F 154-154 disorder
 Evidence X-RAY 5un8 H Reference
       Region 5un8 H 144-145 disorder
       Region 5un8 H 146-153 order
       Region 5un8 H 154-154 disorder
Seq 144-154 Hetero dimer : Q0TR53
 Evidence X-RAY 2ydr P Reference
       Region 2ydr P 144-144 disorder
       Region 2ydr P 145-152 order
       Region 2ydr P 153-154 disorder
Seq 252-258 Homo hexamer :
 Evidence X-RAY 4rp7 Z Reference
       Region 4rp7 Z 253-258 order
 Evidence X-RAY 4rp6 Z Reference
       Region 4rp6 Z 252-258 order
Seq 319-360 Homo tetramer :
 Evidence NMR 3sak D Reference
       Region 3sak D 319-360 order
       Region 3sak D 319-322 high_rmsd
       Region 3sak D 359-360 high_rmsd
 Evidence NMR 3sak C Reference
       Region 3sak C 319-360 order
       Region 3sak C 319-322 high_rmsd
       Region 3sak C 359-360 high_rmsd
 Evidence NMR 3sak B Reference
       Region 3sak B 319-360 order
       Region 3sak B 319-322 high_rmsd
       Region 3sak B 359-360 high_rmsd
 Evidence NMR 3sak A Reference
       Region 3sak A 319-360 order
       Region 3sak A 319-322 high_rmsd
       Region 3sak A 359-360 high_rmsd
 Evidence NMR 1sal D Reference
       Region 1sal D 319-360 order
 Evidence NMR 1sal C Reference
       Region 1sal C 319-360 order
 Evidence NMR 1sal B Reference
       Region 1sal B 319-360 order
 Evidence NMR 1sal A Reference
       Region 1sal A 319-360 order
 Evidence NMR 1sak D Reference
       Region 1sak D 319-360 order
 Evidence NMR 1sak C Reference
       Region 1sak C 319-360 order
 Evidence NMR 1sak B Reference
       Region 1sak B 319-360 order
 Evidence NMR 1sak A Reference
       Region 1sak A 319-360 order
 Evidence NMR 1sae D Reference
       Region 1sae D 319-360 order
       Region 1sae D 319-321 high_rmsd
       Region 1sae D 359-360 high_rmsd
 Evidence NMR 1sae C Reference
       Region 1sae C 319-360 order
       Region 1sae C 319-321 high_rmsd
       Region 1sae C 359-360 high_rmsd
 Evidence NMR 1sae B Reference
       Region 1sae B 319-360 order
       Region 1sae B 319-321 high_rmsd
       Region 1sae B 359-360 high_rmsd
 Evidence NMR 1sae A Reference
       Region 1sae A 319-360 order
       Region 1sae A 319-321 high_rmsd
       Region 1sae A 359-360 high_rmsd
 Evidence NMR 1olh D Reference
       Region 1olh D 319-360 order
       Region 1olh D 319-322 high_rmsd
       Region 1olh D 359-360 high_rmsd
 Evidence NMR 1olh C Reference
       Region 1olh C 319-360 order
       Region 1olh C 319-322 high_rmsd
       Region 1olh C 358-360 high_rmsd
 Evidence NMR 1olh B Reference
       Region 1olh B 319-360 order
       Region 1olh B 319-322 high_rmsd
       Region 1olh B 359-360 high_rmsd
 Evidence NMR 1olh A Reference
       Region 1olh A 319-360 order
       Region 1olh A 319-322 high_rmsd
       Region 1olh A 359-360 high_rmsd
 Evidence NMR 1olg D Reference
       Region 1olg D 319-360 order
 Evidence NMR 1olg C Reference
       Region 1olg C 319-360 order
 Evidence NMR 1olg B Reference
       Region 1olg B 319-360 order
 Evidence NMR 1olg A Reference
       Region 1olg A 319-360 order
 Evidence NMR 1saf D Reference
       Region 1saf D 319-360 order
       Region 1saf D 319-321 high_rmsd
       Region 1saf D 359-360 high_rmsd
 Evidence NMR 1saf C Reference
       Region 1saf C 319-360 order
       Region 1saf C 319-321 high_rmsd
       Region 1saf C 359-360 high_rmsd
 Evidence NMR 1saf B Reference
       Region 1saf B 319-360 order
       Region 1saf B 319-321 high_rmsd
       Region 1saf B 359-360 high_rmsd
 Evidence NMR 1saf A Reference
       Region 1saf A 319-360 order
       Region 1saf A 319-321 high_rmsd
       Region 1saf A 359-360 high_rmsd
 Evidence NMR 2j11 D Reference
       Region 2j11 D 326-356 order
 Evidence NMR 2j11 C Reference
       Region 2j11 C 326-356 order
 Evidence NMR 2j11 B Reference
       Region 2j11 B 326-356 order
       Region 2j11 B 356-356 high_rmsd
 Evidence NMR 2j11 A Reference
       Region 2j11 A 326-356 order
 Evidence NMR 2j10 D Reference
       Region 2j10 D 326-356 order
 Evidence NMR 2j10 C Reference
       Region 2j10 C 326-356 order
 Evidence NMR 2j10 B Reference
       Region 2j10 B 326-356 order
 Evidence NMR 2j10 A Reference
       Region 2j10 A 326-356 order
 Evidence NMR 2j0z D Reference
       Region 2j0z D 326-356 order
 Evidence NMR 2j0z C Reference
       Region 2j0z C 326-356 order
 Evidence NMR 2j0z B Reference
       Region 2j0z B 326-356 order
 Evidence NMR 2j0z A Reference
       Region 2j0z A 326-356 order
 Evidence X-RAY 1c26 A Reference
       Region 1c26 A 325-356 order
 Evidence X-RAY 1aie A Reference
       Region 1aie A 326-356 order
Seq 324-358 Homo dimer :
 Evidence NMR 1hs5 B Reference
       Region 1hs5 B 324-357 order
 Evidence NMR 1hs5 A Reference
       Region 1hs5 A 324-357 order
 Evidence NMR 1a1u C Reference
       Region 1a1u C 324-325 disorder
       Region 1a1u C 326-354 order
       Region 1a1u C 355-358 disorder
 Evidence NMR 1a1u A Reference
       Region 1a1u A 324-325 disorder
       Region 1a1u A 326-354 order
       Region 1a1u A 355-358 disorder
Seq 325-355 Homo tetramer :
 Evidence NMR 1pet D Reference
       Region 1pet D 325-355 order
 Evidence NMR 1pet C Reference
       Region 1pet C 325-355 order
 Evidence NMR 1pet B Reference
       Region 1pet B 325-355 order
 Evidence NMR 1pet A Reference
       Region 1pet A 325-355 order
 Evidence NMR 1pes D Reference
       Region 1pes D 325-355 order
 Evidence NMR 1pes C Reference
       Region 1pes C 325-355 order
 Evidence NMR 1pes B Reference
       Region 1pes B 325-355 order
 Evidence NMR 1pes A Reference
       Region 1pes A 325-355 order
Seq 358-363 Hetero dimer : IID00176Complex
 Evidence X-RAY 2foo B Reference
       Region 2foo B 358-363 order
Seq 359-368 Monomer : IID00176Complex
 Evidence X-RAY 2f1x B Reference
       Region 2f1x B 359-363 order
       Region 2f1x B 364-368 disorder
Seq 359-368 Monomer : IID00176Complex
 Evidence X-RAY 2f1x A Reference
       Region 2f1x A 359-363 order
       Region 2f1x A 364-368 disorder
Seq 361-367 Hetero dimer : IID00176Complex
 Evidence X-RAY 2foj B Reference
       Region 2foj B 361-367 order
Seq 363-377 Hetero dimer : IID00123Complex
 Evidence NMR 2mwo B Reference
       Region 2mwo B 363-377 order
Seq 365-375 Hetero dimer : IID00329Complex
 Evidence X-RAY 3tg5 B Reference
       Region 3tg5 B 365-367 disorder
       Region 3tg5 B 368-375 order
Seq 367-386 Hetero dimer : IID00092Complex
 Evidence NMR 1jsp A Reference
       Region 1jsp A 367-380 disorder
       Region 1jsp A 381-385 order
       Region 1jsp A 386-386 disorder
Seqdisorder 367-388
 Evidence NMR Reference
       Region 367-388 disorder
Seq 367-388 Hetero tetramer : IID50019Complex
 Evidence NMR 1dt7 Y Reference
       Region 1dt7 Y 367-388 order
 Evidence NMR 1dt7 X Reference
       Region 1dt7 X 367-388 order
Seq 369-377 Hetero dimer : IID00128Complex
 Evidence X-RAY 1xqh F Reference
       Region 1xqh F 369-374 order
       Region 1xqh F 375-377 disorder
 Evidence X-RAY 1xqh B Reference
       Region 1xqh B 369-374 order
       Region 1xqh B 375-377 disorder
Seq 372-389 Hetero dimer : IID90001Complex
 Evidence X-RAY 1ma3 B Reference
       Region 1ma3 B 372-378 disorder
       Region 1ma3 B 379-387 order
       Region 1ma3 B 388-389 disorder
Seq 372-389 Hetero dimer : Q8I6E4
 Evidence X-RAY 5ol0 D Reference
       Region 5ol0 D 372-377 disorder
       Region 5ol0 D 378-386 order
       Region 5ol0 D 387-389 disorder
 Evidence X-RAY 5ol0 C Reference
       Region 5ol0 C 372-378 disorder
       Region 5ol0 C 379-386 order
       Region 5ol0 C 387-389 disorder
Seq 372-389 Hetero dimer : IID90011Complex
 Evidence X-RAY 1yc5 B Reference
       Region 1yc5 B 372-372 disorder
       Region 1yc5 B 373-385 order
       Region 1yc5 B 386-389 disorder
 Evidence X-RAY 3pdh D Reference
       Region 3pdh D 372-372 disorder
       Region 3pdh D 373-385 order
       Region 3pdh D 386-389 disorder
 Evidence X-RAY 2h4j D Reference
       Region 2h4j D 372-374 disorder
       Region 2h4j D 375-385 order
       Region 2h4j D 386-389 disorder
 Evidence X-RAY 2h4h B Reference
       Region 2h4h B 372-377 disorder
       Region 2h4h B 378-385 order
       Region 2h4h B 386-389 disorder
 Evidence X-RAY 2h4f D Reference
       Region 2h4f D 372-377 disorder
       Region 2h4f D 378-385 order
       Region 2h4f D 386-389 disorder
 Evidence X-RAY 2h2f B Reference
       Region 2h2f B 372-377 disorder
       Region 2h2f B 378-384 order
       Region 2h2f B 385-389 disorder
 Evidence X-RAY 2h2d B Reference
       Region 2h2d B 372-372 disorder
       Region 2h2d B 373-385 order
       Region 2h2d B 386-389 disorder
 Evidence X-RAY 4buz P Reference
       Region 4buz P 379-385 order
       Region 4buz P 386-386 disorder
Seq 372-389 Hetero tetramer : IID90011Complex
 Evidence X-RAY 4bv2 H Reference
       Region 4bv2 H 376-379 disorder
       Region 4bv2 H 380-384 order
       Region 4bv2 H 385-388 disorder
 Evidence X-RAY 4bv2 E Reference
       Region 4bv2 E 376-379 disorder
       Region 4bv2 E 380-384 order
       Region 4bv2 E 385-388 disorder
 Evidence X-RAY 2h59 E Reference
       Region 2h59 E 372-379 disorder
       Region 2h59 E 380-385 order
       Region 2h59 E 386-389 disorder
 Evidence X-RAY 2h59 D Reference
       Region 2h59 D 372-379 disorder
       Region 2h59 D 380-385 order
       Region 2h59 D 386-389 disorder
Seq 376-386 Hetero trimer : IID00032Complex
 Evidence X-RAY 1h26 E Reference
       Region 1h26 E 376-377 disorder
       Region 1h26 E 378-386 order
Seq 376-387 Hetero dimer : IID00123Complex
 Evidence X-RAY 4x34 D Reference
       Region 4x34 D 377-377 disorder
       Region 4x34 D 378-385 order
       Region 4x34 D 386-386 disorder
 Evidence X-RAY 4x34 C Reference
       Region 4x34 C 377-386 order
 Evidence NMR 2mwp B Reference
       Region 2mwp B 376-387 order
Seqdisorder 377-386
 Evidence X-RAY 3oq5 D Reference
       Region 3oq5 D 377-386 disorder
Seqdisorder 377-386
 Evidence X-RAY 3oq5 E Reference
       Region 3oq5 E 377-386 disorder
Seq 379-383 Hetero dimer : Q96EB6
 Evidence X-RAY 4zzj B Reference
       Region 4zzj B 379-383 order
Seq 382-393 Hetero dimer : IID00301Complex
 Evidence X-RAY 5mhc P Reference
       Region 5mhc P 382-393 order
 Evidence X-RAY 5moc P Reference
       Region 5moc P 382-393 order
Seq 385-393 Hetero tetramer : IID00301Complex
 Evidence X-RAY 3lw1 P Reference
       Region 3lw1 P 385-391 order
       Region 3lw1 P 392-393 disorder
SeqProS verified 1-61 : IID50008Complex
       Region 5hou A 1-61 order
       Region 1-93 disorder
SeqProS verified 1-61 : IID50008Complex
       Region 5hp0 A 37-61 order
       Region 1-93 disorder
SeqProS verified 1-61 Hetero dimer : IID00070Complex
       Region 2mzd B 35-59 order
       Region 1-93 disorder
SeqProS verified 1-61 : IID50008Complex
       Region 5hpd A 2-61 order
       Region 1-93 disorder
SeqProS verified 1-61 Hetero dimer : IID00070Complex
       Region 2k8f B 15-27 order
       Region 1-93 disorder
SeqProS verified 1-61 Hetero dimer : IID50008Complex
       Region 2l14 B 13-61 order
       Region 1-93 disorder
SeqProS verified 14-60 Hetero dimer : IID00297Complex
       Region 2ly4 B 14-60 order
       Region 1-93 disorder
SeqProS verified 16-29 Hetero dimer : IID50094Complex
       Region 2z5s P 17-27 order
       Region 2z5s Q 17-27 order
       Region 2z5s R 18-27 order
       Region 2z5t P 17-27 order
       Region 2z5t Q 17-27 order
       Region 2z5t R 17-27 order
       Region 3dac B 17-29 order
       Region 3dac P 17-28 order
       Region 1-93 disorder
SeqProS verified 16-29 Hetero dimer : IID00005Complex
       Region 3dab B 17-28 order
       Region 3dab D 17-27 order
       Region 3dab F 16-27 order
       Region 3dab H 18-28 order
       Region 1-93 disorder
SeqProS verified 17-29 Hetero tetramer : IID50077Complex
       Region 1ycq B 17-27 order
       Region 1-93 disorder
SeqProS verified 17-29 Hetero dimer : IID00163Complex
       Region 1ycr B 17-29 order
       Region 4hfz B 17-27 order
       Region 4hfz D 17-27 order
       Region 1-93 disorder
SeqProS verified 33-56 Hetero hexamer : IID00036Complex
       Region 2b3g B 33-56 order
       Region 1-93 disorder
SeqProS verified 41-62 Hetero dimer : IID00549Complex
       Region 2ruk A 41-62 order
       Region 1-93 disorder
SeqProS verified 45-58 Hetero dimer : IID50021Complex
       Region 2gs0 B 45-58 order
       Region 1-93 disorder
SeqProS possible 358-367 MDM2 peptide recognizes the same surface groove in HAUSP as that recognized by p53. : IID00176Complex
       Region 2f1x A 359-363 order
SeqProS possible 358-367 MDM2 peptide recognizes the same surface groove in HAUSP as that recognized by p53. Hetero dimer : IID00176Complex
       Region 2foj B 361-367 order
SeqProS possible 358-367 MDM2 peptide recognizes the same surface groove in HAUSP as that recognized by p53. : IID00176Complex
       Region 2f1x B 359-363 order
SeqProS possible 358-367 MDM2 peptide recognizes the same surface groove in HAUSP as that recognized by p53. Hetero dimer : IID00176Complex
       Region 2foo B 358-363 order
SeqProS verified 367-377 Hetero dimer : IID00123Complex
       Region 2mwo B 363-377 order
       Region 367-388 disorder
SeqProS verified 367-388 Hetero tetramer : IID50019Complex
       Region 1dt7 X 367-388 order
       Region 1dt7 Y 367-388 order
       Region 367-388 disorder
SeqProS verified 368-375 Hetero dimer : IID00329Complex
       Region 3tg5 B 368-375 order
       Region 367-388 disorder
SeqProS verified 368-375 Hetero dimer : IID00128Complex
       Region 1xqh B 369-374 order
       Region 1xqh F 369-374 order
       Region 367-388 disorder
SeqProS verified 373-387 Hetero dimer : IID90001Complex
       Region 1ma3 B 379-387 order
       Region 367-388 disorder
SeqProS verified 373-387 Hetero dimer : IID90011Complex
       Region 1yc5 B 373-385 order
       Region 2h2d B 373-385 order
       Region 2h2f B 378-384 order
       Region 2h4f D 378-385 order
       Region 2h4h B 378-385 order
       Region 2h4j D 375-385 order
       Region 3pdh D 373-385 order
       Region 367-388 disorder
SeqProS verified 373-387 Hetero tetramer : IID90011Complex
       Region 2h59 D 380-385 order
       Region 2h59 E 380-385 order
       Region 4bv2 E 380-384 order
       Region 4bv2 H 380-384 order
       Region 367-388 disorder
SeqProS verified 376-387 Hetero dimer : IID00123Complex
       Region 2mwp B 376-387 order
       Region 4x34 C 377-386 order
       Region 4x34 D 378-385 order
       Region 367-388 disorder
SeqProS verified 378-386 Hetero dimer : Q8I6E4
       Region 5ol0 C 379-386 order
       Region 5ol0 D 378-386 order
       Region 367-388 disorder
SeqProS verified 378-386 Hetero trimer : IID00032Complex
       Region 1h26 E 378-386 order
       Region 367-388 disorder
SeqProS verified 381-385 Hetero dimer : IID00092Complex
       Region 1jsp A 381-385 order
       Region 367-388 disorder
SeqProS predicted 382-393 The unbound state of this region is predicted to be disordered by DICHOT, FoldIndex and MobiDB. Hetero dimer : IID00301Complex
       Region 5mhc P 382-393 order
       Region 5moc P 382-393 order
SeqProS possible 385-391 14-3-3 binding motif Hetero tetramer : IID00301Complex
       Region 3lw1 P 385-391 order
Seqphosphorylation
    392-392 Phosphoserine; by CK2
    315-315 Phosphoserine; by AURKA
    284-284 Phosphothreonine; by AURKB
    269-269 Phosphoserine; by AURKB
    183-183 Phosphoserine; by AURKB
    55-55 Phosphothreonine; by TAF1 and GRK5
    46-46 Phosphoserine; by CDK5
    37-37 Phosphoserine; by MAPKAPK5
    33-33 Phosphoserine; by CDK5 and CDK7
    20-20 Phosphoserine; by CHEK2
    18-18 Phosphothreonine; by CK1
    9-9 Phosphoserine; by HIPK4
    15-15 Phosphoserine; by CDK5
Seqacetylation
    382-382 N6-acetyllysine; by KAT6A; alternate
    381-381 N6-acetyllysine
    373-373 N6-acetyllysine; alternate
    321-321 N6-acetyllysine
    305-305 N6-acetyllysine
    120-120 N6-acetyllysine; by KAT6A
 
Prediction
NeProc
Disorder 1-93,285-321,357-393
Order 94-116,121-243,251-284,322-356
ProS 10-57,285-289,357-363,381-393
AlphaFold
Disorder 1-23,26-95,183-183,185-185,293-323,356-393
Order 24-25,96-182,184-184,186-292,324-355
Pfam Hmmer
PF08563 5-29 9.8e-11
PF00870 95-289 1.2e-150
PF07710 318-359 1.5e-22
SEG 63-89
Function
Function in SwissProt
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 (PubMed:12524540). However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP (PubMed:12524540). In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492).
Biological Process
Diagram with PDB data
TP53/EP300Structural Basis for the Regulation of p53 Function by p300
TP53/CREBBPNMR Structure of CBP Bromodomain in complex with p53 peptide
TP53/SETD7Crystal structure of a ternary complex of the methyltransferase SET9 (also known as SET7/9) with a P53 peptide and SAH
TP53/SMYD2Structure of SMYD2 in complex with p53 and SAH
TP53/HMGB1HMGB1-facilitated p53 DNA binding occurs via HMG-box/p53 transactivation domain interaction and is regulated by the acidic tail
TP53/GTF2H1Solution structure of the complex between p53 transactivation domain 2 and TFIIH p62 PH domain
TP53/MDM2Crystal Structure of an MDM2/P53 Peptide Complex
TP53/MDM4Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain
TP53/S100BSOLUTION STRUCTURE OF THE C-TERMINAL NEGATIVE REGULATORY DOMAIN OF P53 IN A COMPLEX WITH CA2+-BOUND S100B(BB)
TP53/CCNA2 /CDK2CDK2/CyclinA in complex with an 11-residue recruitment peptide from p53
TP53/SFNCrystal structure of 14-3-3sigma and a p53 C-terminal 12-mer synthetic phosphopeptide
TP53/TP53BP1Solution structure of 53BP1 tandem Tudor domains in complex with a p53K382me2 peptide
See also
Diagram with PDB data
MDM4/USP7Crystal Structure of the USP7:HdmX(AHSS) complex
Crebbp/TP53Structure of CBP nuclear coactivator binding domain in complex with p53 TAD
mdm2NMR Structure of a Complex Between MDM2 and a Small Molecule Inhibitor
MDM2/USP7The Crystal Structure of the N-terminal domain of HAUSP/USP7 complexed with mdm2 peptide 147-150
mdm4/TP53Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain