Structure
atLeast majority ProS Experiment
:order disorder conflict PDB cluster ProS Pfam Domain SEG
393
order/disorder by at least rule
disorder by at least rule
order/disorder by majority rule
Seq 1-39 Hetero dimer : IID00070 Complex
Region 2k8f B 1-14 disorder
Region 2k8f B 1-2 high_rmsd
Region 2k8f B 15-27 order
Region 2k8f B 28-39 disorder
Region 2k8f B 38-39 high_rmsd
Seq 1-61 Monomer : IID50008 Complex
Region 5hou A 1-13 high_rmsd
Region 5hou A 59-61 high_rmsd
Seq 1-93 Hetero dimer : IID00297 Complex
Region 2ly4 B 1-13 disorder
Region 2ly4 B 14-60 order
Region 2ly4 B 14-39 high_rmsd
Region 2ly4 B 56-60 high_rmsd
Region 2ly4 B 61-93 disorder
Seq 2-61 Monomer : IID50008 Complex
Region 5hpd A 2-13 high_rmsd
Region 5hpd A 59-61 high_rmsd
Seq 13-29 Hetero tetramer : IID50077 Complex
Region 1ycq B 13-16 disorder
Region 1ycq B 17-27 order
Region 1ycq B 28-29 disorder
Seq 13-61 Hetero dimer : IID50008 Complex
Region 2l14 B 13-61 order
Region 2l14 B 13-16 high_rmsd
Region 2l14 B 27-38 high_rmsd
Region 2l14 B 58-61 high_rmsd
Seq 15-29 Hetero dimer : IID00163 Complex
Region 1ycr B 15-16 disorder
Region 1ycr B 17-29 order
Region 4hfz D 15-16 disorder
Region 4hfz D 17-27 order
Region 4hfz D 28-29 disorder
Region 4hfz B 15-16 disorder
Region 4hfz B 17-27 order
Region 4hfz B 28-29 disorder
Seq 15-29 Hetero dimer : IID00005 Complex
Region 2mwy B 15-29 order
Region 2mwy B 15-17 high_rmsd
Region 2mwy B 29-29 high_rmsd
Region 3dab H 15-17 disorder
Region 3dab H 18-28 order
Region 3dab H 29-29 disorder
Region 3dab F 15-15 disorder
Region 3dab F 16-27 order
Region 3dab F 28-29 disorder
Region 3dab D 15-16 disorder
Region 3dab D 17-27 order
Region 3dab D 28-29 disorder
Region 3dab B 15-16 disorder
Region 3dab B 17-28 order
Region 3dab B 29-29 disorder
Seq 15-37 Hetero dimer : IID50094 Complex
Region 2z5t R 15-16 disorder
Region 2z5t R 17-27 order
Region 2z5t R 28-29 disorder
Region 2z5t Q 15-16 disorder
Region 2z5t Q 17-27 order
Region 2z5t Q 28-29 disorder
Region 2z5t P 15-16 disorder
Region 2z5t P 17-27 order
Region 2z5t P 28-29 disorder
Region 2z5s R 15-17 disorder
Region 2z5s R 18-27 order
Region 2z5s R 28-29 disorder
Region 2z5s Q 15-16 disorder
Region 2z5s Q 17-27 order
Region 2z5s Q 28-29 disorder
Region 2z5s P 15-16 disorder
Region 2z5s P 17-27 order
Region 2z5s P 28-29 disorder
Region 3dac B 17-29 order
Region 3dac B 30-37 disorder
Region 3dac P 17-28 order
Region 3dac P 29-37 disorder
Seq 20-73 Hetero dimer : IID50021 Complex
Region 2gs0 B 20-44 disorder
Region 2gs0 B 45-58 order
Region 2gs0 B 58-58 high_rmsd
Region 2gs0 B 59-73 disorder
Seq 33-60 Hetero hexamer : IID00036 Complex
Region 2b3g B 33-56 order
Region 2b3g B 57-60 disorder
Seq 35-59 Hetero dimer : IID00070 Complex
Region 2mzd B 35-59 order
Region 2mzd B 35-37 high_rmsd
Region 2mzd B 59-59 high_rmsd
Seq 37-61 Monomer : IID50008 Complex
Region 5hp0 A 37-61 order
Region 5hp0 A 57-61 high_rmsd
Seq 41-62 Hetero dimer : IID00549 Complex
Region 2ruk A 41-62 order
Region 2fej A 94-297 order
Region 2fej A 94-95 high_rmsd
Region 2fej A 293-297 high_rmsd
Region 3zme B 94-94 disorder
Region 3zme B 95-291 order
Region 3zme B 292-312 disorder
Region 3zme A 94-95 disorder
Region 3zme A 96-290 order
Region 3zme A 291-312 disorder
Region 2xwr B 89-90 disorder
Region 2xwr B 91-290 order
Region 2xwr B 291-293 disorder
Region 2xwr A 89-90 disorder
Region 2xwr A 91-289 order
Region 2xwr A 290-293 disorder
Region 2x0w B 94-96 disorder
Region 2x0w B 97-290 order
Region 2x0w B 291-312 disorder
Region 2x0w A 94-95 disorder
Region 2x0w A 96-290 order
Region 2x0w A 291-312 disorder
Region 2x0v B 94-94 disorder
Region 2x0v B 95-289 order
Region 2x0v B 290-312 disorder
Region 2x0v A 94-95 disorder
Region 2x0v A 96-220 order
Region 2x0v A 221-222 disorder
Region 2x0v A 223-290 order
Region 2x0v A 291-312 disorder
Region 2x0u B 94-96 disorder
Region 2x0u B 97-290 order
Region 2x0u B 291-312 disorder
Region 2x0u A 94-95 disorder
Region 2x0u A 96-290 order
Region 2x0u A 291-312 disorder
Region 2wgx B 94-96 disorder
Region 2wgx B 97-290 order
Region 2wgx B 291-312 disorder
Region 2wgx A 94-95 disorder
Region 2wgx A 96-290 order
Region 2wgx A 291-312 disorder
Region 2vuk B 94-94 disorder
Region 2vuk B 95-290 order
Region 2vuk B 291-312 disorder
Region 2vuk A 94-95 disorder
Region 2vuk A 96-290 order
Region 2vuk A 291-312 disorder
Region 1uol B 94-95 disorder
Region 1uol B 96-290 order
Region 1uol B 291-312 disorder
Region 1uol A 94-95 disorder
Region 1uol A 96-290 order
Region 1uol A 291-312 disorder
Region 2pcx A 94-292 order
Region 2ocj D 94-95 disorder
Region 2ocj D 96-289 order
Region 2ocj D 290-312 disorder
Region 2ocj C 94-95 disorder
Region 2ocj C 96-289 order
Region 2ocj C 290-312 disorder
Region 2ocj B 94-95 disorder
Region 2ocj B 96-289 order
Region 2ocj B 290-312 disorder
Region 2ocj A 94-95 disorder
Region 2ocj A 96-289 order
Region 2ocj A 290-312 disorder
Region 4mzi A 94-95 disorder
Region 4mzi A 96-288 order
Region 4mzi A 289-292 disorder
Region 4lof A 94-291 order
Region 4lof A 292-312 disorder
Region 4loe D 94-95 disorder
Region 4loe D 96-289 order
Region 4loe D 290-312 disorder
Region 4loe C 94-95 disorder
Region 4loe C 96-289 order
Region 4loe C 290-312 disorder
Region 4loe B 94-95 disorder
Region 4loe B 96-289 order
Region 4loe B 290-312 disorder
Region 4loe A 94-95 disorder
Region 4loe A 96-289 order
Region 4loe A 290-312 disorder
Region 4lo9 D 94-95 disorder
Region 4lo9 D 96-289 order
Region 4lo9 D 290-312 disorder
Region 4lo9 C 94-95 disorder
Region 4lo9 C 96-289 order
Region 4lo9 C 290-312 disorder
Region 4lo9 B 94-95 disorder
Region 4lo9 B 96-289 order
Region 4lo9 B 290-312 disorder
Region 4lo9 A 94-95 disorder
Region 4lo9 A 96-289 order
Region 4lo9 A 290-312 disorder
Region 5lap B 94-94 disorder
Region 5lap B 95-290 order
Region 5lap B 291-312 disorder
Region 5lap A 94-95 disorder
Region 5lap A 96-290 order
Region 5lap A 291-312 disorder
Region 4kvp D 94-95 disorder
Region 4kvp D 96-289 order
Region 4kvp D 290-312 disorder
Region 4kvp C 94-94 disorder
Region 4kvp C 95-289 order
Region 4kvp C 290-312 disorder
Region 4kvp B 94-95 disorder
Region 4kvp B 96-289 order
Region 4kvp B 290-312 disorder
Region 4kvp A 94-95 disorder
Region 4kvp A 96-289 order
Region 4kvp A 290-312 disorder
Region 2j21 B 94-95 disorder
Region 2j21 B 96-115 order
Region 2j21 B 116-121 disorder
Region 2j21 B 122-289 order
Region 2j21 B 290-312 disorder
Region 2j21 A 94-95 disorder
Region 2j21 A 96-116 order
Region 2j21 A 117-121 disorder
Region 2j21 A 122-288 order
Region 2j21 A 289-312 disorder
Region 2j20 B 94-96 disorder
Region 2j20 B 97-290 order
Region 2j20 B 291-312 disorder
Region 2j20 A 94-95 disorder
Region 2j20 A 96-290 order
Region 2j20 A 291-312 disorder
Region 2j1z B 94-95 disorder
Region 2j1z B 96-290 order
Region 2j1z B 291-312 disorder
Region 2j1z A 94-95 disorder
Region 2j1z A 96-290 order
Region 2j1z A 291-312 disorder
Region 2j1y D 94-95 disorder
Region 2j1y D 96-182 order
Region 2j1y D 183-184 disorder
Region 2j1y D 185-289 order
Region 2j1y D 290-293 disorder
Region 2j1y C 94-95 disorder
Region 2j1y C 96-181 order
Region 2j1y C 182-184 disorder
Region 2j1y C 185-289 order
Region 2j1y C 290-293 disorder
Region 2j1y B 94-95 disorder
Region 2j1y B 96-183 order
Region 2j1y B 184-184 disorder
Region 2j1y B 185-289 order
Region 2j1y B 290-293 disorder
Region 2j1y A 94-94 disorder
Region 2j1y A 95-181 order
Region 2j1y A 182-184 disorder
Region 2j1y A 185-289 order
Region 2j1y A 290-293 disorder
Region 2j1x B 94-96 disorder
Region 2j1x B 97-291 order
Region 2j1x B 292-312 disorder
Region 2j1x A 94-95 disorder
Region 2j1x A 96-290 order
Region 2j1x A 291-312 disorder
Region 2j1w B 94-95 disorder
Region 2j1w B 96-290 order
Region 2j1w B 291-312 disorder
Region 2j1w A 94-95 disorder
Region 2j1w A 96-290 order
Region 2j1w A 291-312 disorder
Region 4ijt A 94-291 order
Region 4ijt A 292-293 disorder
Region 4ibz D 94-95 disorder
Region 4ibz D 96-225 order
Region 4ibz D 226-226 disorder
Region 4ibz D 227-288 order
Region 4ibz D 289-293 disorder
Region 4ibz C 94-95 disorder
Region 4ibz C 96-182 order
Region 4ibz C 183-184 disorder
Region 4ibz C 185-289 order
Region 4ibz C 290-293 disorder
Region 4ibz B 94-96 disorder
Region 4ibz B 97-288 order
Region 4ibz B 289-293 disorder
Region 4ibz A 94-95 disorder
Region 4ibz A 96-288 order
Region 4ibz A 289-293 disorder
Region 4iby B 94-289 order
Region 4iby B 290-293 disorder
Region 4iby A 94-290 order
Region 4iby A 291-293 disorder
Region 4ibt D 94-94 disorder
Region 4ibt D 95-289 order
Region 4ibt D 290-293 disorder
Region 4ibt C 94-290 order
Region 4ibt C 291-293 disorder
Region 4ibt B 94-94 disorder
Region 4ibt B 95-289 order
Region 4ibt B 290-293 disorder
Region 4ibt A 94-94 disorder
Region 4ibt A 95-290 order
Region 4ibt A 291-293 disorder
Region 4ibs D 94-95 disorder
Region 4ibs D 96-289 order
Region 4ibs D 290-293 disorder
Region 4ibs C 94-95 disorder
Region 4ibs C 96-289 order
Region 4ibs C 290-293 disorder
Region 4ibs B 94-95 disorder
Region 4ibs B 96-289 order
Region 4ibs B 290-293 disorder
Region 4ibs A 94-95 disorder
Region 4ibs A 96-288 order
Region 4ibs A 289-293 disorder
Region 4ibq D 94-95 disorder
Region 4ibq D 96-288 order
Region 4ibq D 289-293 disorder
Region 4ibq C 94-96 disorder
Region 4ibq C 97-288 order
Region 4ibq C 289-293 disorder
Region 4ibq B 94-95 disorder
Region 4ibq B 96-288 order
Region 4ibq B 289-293 disorder
Region 4ibq A 94-96 disorder
Region 4ibq A 97-288 order
Region 4ibq A 289-293 disorder
Region 3d09 A 94-95 disorder
Region 3d09 A 96-116 order
Region 3d09 A 117-121 disorder
Region 3d09 A 122-182 order
Region 3d09 A 183-184 disorder
Region 3d09 A 185-290 order
Region 3d09 A 291-293 disorder
Region 3d08 A 94-96 disorder
Region 3d08 A 97-116 order
Region 3d08 A 117-121 disorder
Region 3d08 A 122-182 order
Region 3d08 A 183-186 disorder
Region 3d08 A 187-287 order
Region 3d08 A 288-293 disorder
Region 3d07 B 94-94 disorder
Region 3d07 B 95-247 order
Region 3d07 B 248-248 disorder
Region 3d07 B 249-292 order
Region 3d07 B 293-293 disorder
Region 3d07 A 94-246 order
Region 3d07 A 247-247 disorder
Region 3d07 A 248-288 order
Region 3d07 A 289-293 disorder
Region 3d06 A 94-96 disorder
Region 3d06 A 97-114 order
Region 3d06 A 115-121 disorder
Region 3d06 A 122-181 order
Region 3d06 A 182-187 disorder
Region 3d06 A 188-288 order
Region 3d06 A 289-293 disorder
Region 3d05 A 94-95 disorder
Region 3d05 A 96-114 order
Region 3d05 A 115-121 disorder
Region 3d05 A 122-181 order
Region 3d05 A 182-184 disorder
Region 3d05 A 185-288 order
Region 3d05 A 289-293 disorder
Region 2biq A 94-95 disorder
Region 2biq A 96-114 order
Region 2biq A 115-120 disorder
Region 2biq A 121-182 order
Region 2biq A 183-184 disorder
Region 2biq A 185-242 order
Region 2biq A 243-244 disorder
Region 2biq A 245-290 order
Region 2biq A 291-312 disorder
Region 2bip A 94-95 disorder
Region 2bip A 96-114 order
Region 2bip A 115-120 disorder
Region 2bip A 121-182 order
Region 2bip A 183-184 disorder
Region 2bip A 185-242 order
Region 2bip A 243-244 disorder
Region 2bip A 245-290 order
Region 2bip A 291-312 disorder
Region 2bio A 94-96 disorder
Region 2bio A 97-116 order
Region 2bio A 117-120 disorder
Region 2bio A 121-181 order
Region 2bio A 182-185 disorder
Region 2bio A 186-290 order
Region 2bio A 291-312 disorder
Region 2bin A 94-96 disorder
Region 2bin A 97-116 order
Region 2bin A 117-120 disorder
Region 2bin A 121-165 order
Region 2bin A 166-170 disorder
Region 2bin A 171-181 order
Region 2bin A 182-184 disorder
Region 2bin A 185-291 order
Region 2bin A 292-312 disorder
Region 2bim B 94-95 disorder
Region 2bim B 96-290 order
Region 2bim B 291-312 disorder
Region 2bim A 94-95 disorder
Region 2bim A 96-290 order
Region 2bim A 291-312 disorder
Region 5aom B 94-94 disorder
Region 5aom B 95-289 order
Region 5aom B 290-312 disorder
Region 5aom A 94-95 disorder
Region 5aom A 96-290 order
Region 5aom A 291-312 disorder
Region 5aol B 94-290 order
Region 5aol B 291-312 disorder
Region 5aol A 94-95 disorder
Region 5aol A 96-292 order
Region 5aol A 293-312 disorder
Region 5aok B 94-291 order
Region 5aok B 292-312 disorder
Region 5aok A 94-95 disorder
Region 5aok A 96-290 order
Region 5aok A 291-312 disorder
Region 5aoj B 94-290 order
Region 5aoj B 291-312 disorder
Region 5aoj A 94-95 disorder
Region 5aoj A 96-290 order
Region 5aoj A 291-312 disorder
Region 5aoi B 94-94 disorder
Region 5aoi B 95-290 order
Region 5aoi B 291-312 disorder
Region 5aoi A 94-95 disorder
Region 5aoi A 96-290 order
Region 5aoi A 291-312 disorder
Region 4agq B 94-289 order
Region 4agq B 290-312 disorder
Region 4agq A 94-95 disorder
Region 4agq A 96-290 order
Region 4agq A 291-312 disorder
Region 4agp B 94-290 order
Region 4agp B 291-312 disorder
Region 4agp A 94-95 disorder
Region 4agp A 96-291 order
Region 4agp A 292-312 disorder
Region 4ago B 94-289 order
Region 4ago B 290-312 disorder
Region 4ago A 94-95 disorder
Region 4ago A 96-291 order
Region 4ago A 292-312 disorder
Region 4agn B 94-290 order
Region 4agn B 291-312 disorder
Region 4agn A 94-95 disorder
Region 4agn A 96-292 order
Region 4agn A 293-312 disorder
Region 4agl B 94-290 order
Region 4agl B 291-312 disorder
Region 4agl A 94-95 disorder
Region 4agl A 96-290 order
Region 4agl A 291-312 disorder
Region 5aba B 94-290 order
Region 5aba B 291-312 disorder
Region 5aba A 94-95 disorder
Region 5aba A 96-290 order
Region 5aba A 291-312 disorder
Region 5ab9 B 94-94 disorder
Region 5ab9 B 95-291 order
Region 5ab9 B 292-312 disorder
Region 5ab9 A 94-95 disorder
Region 5ab9 A 96-290 order
Region 5ab9 A 291-312 disorder
Region 5a7b B 94-290 order
Region 5a7b B 291-312 disorder
Region 5a7b A 94-95 disorder
Region 5a7b A 96-291 order
Region 5a7b A 292-312 disorder
Seq 92-292 Hetero dodecamer : IID90002 Complex
Region 2h1l X 92-289 order
Region 2h1l X 290-292 disorder
Region 2h1l W 92-289 order
Region 2h1l W 290-292 disorder
Region 2h1l V 92-289 order
Region 2h1l V 290-292 disorder
Region 2h1l U 92-289 order
Region 2h1l U 290-292 disorder
Region 2h1l T 92-289 order
Region 2h1l T 290-292 disorder
Region 2h1l S 92-289 order
Region 2h1l S 290-292 disorder
Region 2h1l R 92-289 order
Region 2h1l R 290-292 disorder
Region 2h1l Q 92-289 order
Region 2h1l Q 290-292 disorder
Region 2h1l P 92-289 order
Region 2h1l P 290-292 disorder
Region 2h1l O 92-289 order
Region 2h1l O 290-292 disorder
Region 2h1l N 92-289 order
Region 2h1l N 290-292 disorder
Region 2h1l M 92-289 order
Region 2h1l M 290-292 disorder
Seq 92-312 Hetero dimer :
Region 4qo1 B 92-290 order
Region 4qo1 B 291-312 disorder
Seq 92-293,319-358 Homo tetramer :
Region 3ts8 D 94-290 order
Region 3ts8 D 320-356 order
Region 3ts8 C 94-290 order
Region 3ts8 C 320-356 order
Region 3ts8 B 94-290 order
Region 3ts8 B 320-356 order
Region 3ts8 A 94-290 order
Region 3ts8 A 320-356 order
Region 3q06 D 96-290 order
Region 3q06 D 319-354 order
Region 3q06 C 96-290 order
Region 3q06 C 319-354 order
Region 3q06 B 96-290 order
Region 3q06 B 319-354 order
Region 3q06 A 96-290 order
Region 3q06 A 319-354 order
Region 3q05 D 94-290 order
Region 3q05 D 320-356 order
Region 3q05 C 94-290 order
Region 3q05 C 320-356 order
Region 3q05 B 94-290 order
Region 3q05 B 320-356 order
Region 3q05 A 94-290 order
Region 3q05 A 320-356 order
Region 4mzr D 94-290 order
Region 4mzr D 320-356 order
Region 4mzr D 357-358 disorder
Region 4mzr C 94-290 order
Region 4mzr C 320-356 order
Region 4mzr C 357-358 disorder
Region 4mzr B 94-290 order
Region 4mzr B 320-356 order
Region 4mzr B 357-358 disorder
Region 4mzr A 94-290 order
Region 4mzr A 320-356 order
Region 4mzr A 357-358 disorder
Region 5lgy D 94-94 disorder
Region 5lgy D 95-291 order
Region 5lgy C 94-94 disorder
Region 5lgy C 95-291 order
Region 5lgy B 94-291 order
Region 5lgy A 94-94 disorder
Region 5lgy A 95-291 order
Region 3kz8 B 94-94 disorder
Region 3kz8 B 95-184 order
Region 3kz8 B 185-187 disorder
Region 3kz8 B 188-292 order
Region 3kz8 B 293-293 disorder
Region 3kz8 A 94-94 disorder
Region 3kz8 A 95-184 order
Region 3kz8 A 185-187 disorder
Region 3kz8 A 188-292 order
Region 3kz8 A 293-293 disorder
Region 3kmd D 92-291 order
Region 3kmd C 92-291 order
Region 3kmd B 92-291 order
Region 3kmd A 92-291 order
Region 4ibu D 94-94 disorder
Region 4ibu D 95-290 order
Region 4ibu D 291-293 disorder
Region 4ibu C 94-95 disorder
Region 4ibu C 96-290 order
Region 4ibu C 291-293 disorder
Region 4ibu B 94-291 order
Region 4ibu B 292-293 disorder
Region 4ibu A 94-95 disorder
Region 4ibu A 96-292 order
Region 4ibu A 293-293 disorder
Region 4hje D 92-291 order
Region 4hje C 92-291 order
Region 4hje B 92-291 order
Region 4hje A 92-291 order
Region 2ata D 94-290 order
Region 2ata D 291-293 disorder
Region 2ata C 94-95 disorder
Region 2ata C 96-290 order
Region 2ata C 291-293 disorder
Region 2ata B 94-291 order
Region 2ata B 292-293 disorder
Region 2ata A 94-95 disorder
Region 2ata A 96-292 order
Region 2ata A 293-293 disorder
Region 2ahi D 94-95 disorder
Region 2ahi D 96-291 order
Region 2ahi D 292-293 disorder
Region 2ahi C 94-95 disorder
Region 2ahi C 96-288 order
Region 2ahi C 289-293 disorder
Region 2ahi B 94-291 order
Region 2ahi B 292-293 disorder
Region 2ahi A 94-94 disorder
Region 2ahi A 95-292 order
Region 2ahi A 293-293 disorder
Region 2ady B 94-291 order
Region 2ady B 292-293 disorder
Region 2ady A 94-94 disorder
Region 2ady A 95-291 order
Region 2ady A 292-293 disorder
Region 2ac0 D 94-95 disorder
Region 2ac0 D 96-293 order
Region 2ac0 C 94-95 disorder
Region 2ac0 C 96-290 order
Region 2ac0 C 291-293 disorder
Region 2ac0 B 94-291 order
Region 2ac0 B 292-293 disorder
Region 2ac0 A 94-291 order
Region 2ac0 A 292-293 disorder
Seq 94-292 Hetero trimer : IID00209 Complex ,
IID90005 Complex ,
IID90020 Complex
Region 4xr8 D 94-292 order
Seq 94-292 Hetero trimer : IID00209 Complex ,
IID90005 Complex ,
IID90020 Complex
Region 4xr8 C 94-292 order
Seq 94-292 Hetero dimer : IID00124 Complex
Region 1ycs A 94-96 disorder
Region 1ycs A 97-287 order
Region 1ycs A 288-292 disorder
Seq 94-293 Homo tetramer :
Region 2ybg A 94-95 disorder
Region 2ybg A 96-225 order
Region 2ybg A 226-226 disorder
Region 2ybg A 227-288 order
Region 2ybg A 289-293 disorder
Region 2ybg B 94-95 disorder
Region 2ybg B 96-288 order
Region 2ybg B 289-293 disorder
Region 2ybg C 94-95 disorder
Region 2ybg C 96-289 order
Region 2ybg C 290-293 disorder
Region 2ybg D 94-95 disorder
Region 2ybg D 96-289 order
Region 2ybg D 290-293 disorder
Region 1tup C 94-94 disorder
Region 1tup C 95-289 order
Region 1tup C 290-312 disorder
Region 1tup B 94-95 disorder
Region 1tup B 96-289 order
Region 1tup B 290-312 disorder
Region 1tup A 94-289 order
Region 1tup A 290-312 disorder
Region 1tsr C 94-94 disorder
Region 1tsr C 95-289 order
Region 1tsr C 290-312 disorder
Region 1tsr B 94-95 disorder
Region 1tsr B 96-289 order
Region 1tsr B 290-312 disorder
Region 1tsr A 94-289 order
Region 1tsr A 290-312 disorder
Seq 94-312,321-356 Homo dimer :
Region 5g4o B 94-290 order
Region 5g4o B 291-312 disorder
Region 5g4o A 94-95 disorder
Region 5g4o A 96-291 order
Region 5g4o A 292-312 disorder
Region 5g4n B 94-290 order
Region 5g4n B 291-312 disorder
Region 5g4n A 94-95 disorder
Region 5g4n A 96-291 order
Region 5g4n A 292-312 disorder
Region 5g4m B 94-290 order
Region 5g4m B 291-312 disorder
Region 5g4m A 94-95 disorder
Region 5g4m A 96-290 order
Region 5g4m A 291-312 disorder
Region 4agm B 94-291 order
Region 4agm B 292-312 disorder
Region 4agm A 94-95 disorder
Region 4agm A 96-292 order
Region 4agm A 293-312 disorder
Region 3q01 B 94-290 order
Region 3q01 B 321-356 order
Region 3q01 A 94-290 order
Region 3q01 A 321-356 order
Region 3igl A 94-183 order
Region 3igl A 184-186 disorder
Region 3igl A 187-293 order
Region 3igk A 94-183 order
Region 3igk A 184-186 disorder
Region 3igk A 187-293 order
Region 4ibw A 94-182 order
Region 4ibw A 183-185 disorder
Region 4ibw A 186-293 order
Region 4ibv A 94-183 order
Region 4ibv A 184-186 disorder
Region 4ibv A 187-293 order
Region 3d0a D 94-94 disorder
Region 3d0a D 95-288 order
Region 3d0a D 289-293 disorder
Region 3d0a C 94-95 disorder
Region 3d0a C 96-288 order
Region 3d0a C 289-293 disorder
Region 3d0a B 94-94 disorder
Region 3d0a B 95-291 order
Region 3d0a B 292-293 disorder
Region 3d0a A 94-95 disorder
Region 3d0a A 96-291 order
Region 3d0a A 292-293 disorder
Region 5bua A 94-293 order
Seq 95-289 Hetero tetramer : IID00123 Complex
Region 1kzy B 95-289 order
Region 1kzy A 95-289 order
Seq 95-312 Hetero dimer : IID00123 Complex
Region 1gzh C 95-289 order
Region 1gzh C 290-292 disorder
Region 1gzh A 95-182 order
Region 1gzh A 183-188 disorder
Region 1gzh A 189-199 order
Region 1gzh A 200-200 disorder
Region 1gzh A 201-223 order
Region 1gzh A 224-227 disorder
Region 1gzh A 228-292 order
Region 5ecg B 95-95 disorder
Region 5ecg B 96-114 order
Region 5ecg B 115-121 disorder
Region 5ecg B 122-182 order
Region 5ecg B 183-186 disorder
Region 5ecg B 187-289 order
Region 5ecg B 290-312 disorder
Region 5ecg A 95-95 disorder
Region 5ecg A 96-116 order
Region 5ecg A 117-120 disorder
Region 5ecg A 121-182 order
Region 5ecg A 183-184 disorder
Region 5ecg A 185-293 order
Region 5ecg A 294-312 disorder
Seq 96-312 Hetero dimer : IID00720 Complex
Region 2mej B 96-290 order
Region 2mej B 291-312 disorder
Seq 144-154 Hetero tetramer : IID00643 Complex
Region 5un8 E 144-145 disorder
Region 5un8 E 146-152 order
Region 5un8 E 153-154 disorder
Region 5un8 G 144-145 disorder
Region 5un8 G 146-154 order
Seq 144-154 Hetero tetramer : IID00643 Complex
Region 5un8 F 144-145 disorder
Region 5un8 F 146-153 order
Region 5un8 F 154-154 disorder
Region 5un8 H 144-145 disorder
Region 5un8 H 146-153 order
Region 5un8 H 154-154 disorder
Seq 144-154 Hetero dimer : Q0TR53
Region 2ydr P 144-144 disorder
Region 2ydr P 145-152 order
Region 2ydr P 153-154 disorder
Seq 252-258 Homo hexamer :
Region 4rp7 Z 253-258 order
Region 4rp6 Z 252-258 order
Seq 319-360 Homo tetramer :
Region 3sak D 319-360 order
Region 3sak D 319-322 high_rmsd
Region 3sak D 359-360 high_rmsd
Region 3sak C 319-360 order
Region 3sak C 319-322 high_rmsd
Region 3sak C 359-360 high_rmsd
Region 3sak B 319-360 order
Region 3sak B 319-322 high_rmsd
Region 3sak B 359-360 high_rmsd
Region 3sak A 319-360 order
Region 3sak A 319-322 high_rmsd
Region 3sak A 359-360 high_rmsd
Region 1sal D 319-360 order
Region 1sal C 319-360 order
Region 1sal B 319-360 order
Region 1sal A 319-360 order
Region 1sak D 319-360 order
Region 1sak C 319-360 order
Region 1sak B 319-360 order
Region 1sak A 319-360 order
Region 1sae D 319-360 order
Region 1sae D 319-321 high_rmsd
Region 1sae D 359-360 high_rmsd
Region 1sae C 319-360 order
Region 1sae C 319-321 high_rmsd
Region 1sae C 359-360 high_rmsd
Region 1sae B 319-360 order
Region 1sae B 319-321 high_rmsd
Region 1sae B 359-360 high_rmsd
Region 1sae A 319-360 order
Region 1sae A 319-321 high_rmsd
Region 1sae A 359-360 high_rmsd
Region 1olh D 319-360 order
Region 1olh D 319-322 high_rmsd
Region 1olh D 359-360 high_rmsd
Region 1olh C 319-360 order
Region 1olh C 319-322 high_rmsd
Region 1olh C 358-360 high_rmsd
Region 1olh B 319-360 order
Region 1olh B 319-322 high_rmsd
Region 1olh B 359-360 high_rmsd
Region 1olh A 319-360 order
Region 1olh A 319-322 high_rmsd
Region 1olh A 359-360 high_rmsd
Region 1olg D 319-360 order
Region 1olg C 319-360 order
Region 1olg B 319-360 order
Region 1olg A 319-360 order
Region 1saf D 319-360 order
Region 1saf D 319-321 high_rmsd
Region 1saf D 359-360 high_rmsd
Region 1saf C 319-360 order
Region 1saf C 319-321 high_rmsd
Region 1saf C 359-360 high_rmsd
Region 1saf B 319-360 order
Region 1saf B 319-321 high_rmsd
Region 1saf B 359-360 high_rmsd
Region 1saf A 319-360 order
Region 1saf A 319-321 high_rmsd
Region 1saf A 359-360 high_rmsd
Region 2j11 D 326-356 order
Region 2j11 C 326-356 order
Region 2j11 B 326-356 order
Region 2j11 B 356-356 high_rmsd
Region 2j11 A 326-356 order
Region 2j10 D 326-356 order
Region 2j10 C 326-356 order
Region 2j10 B 326-356 order
Region 2j10 A 326-356 order
Region 2j0z D 326-356 order
Region 2j0z C 326-356 order
Region 2j0z B 326-356 order
Region 2j0z A 326-356 order
Region 1c26 A 325-356 order
Region 1aie A 326-356 order
Region 1hs5 B 324-357 order
Region 1hs5 A 324-357 order
Region 1a1u C 324-325 disorder
Region 1a1u C 326-354 order
Region 1a1u C 355-358 disorder
Region 1a1u A 324-325 disorder
Region 1a1u A 326-354 order
Region 1a1u A 355-358 disorder
Seq 325-355 Homo tetramer :
Region 1pet D 325-355 order
Region 1pet C 325-355 order
Region 1pet B 325-355 order
Region 1pet A 325-355 order
Region 1pes D 325-355 order
Region 1pes C 325-355 order
Region 1pes B 325-355 order
Region 1pes A 325-355 order
Seq 358-363 Hetero dimer : IID00176 Complex
Region 2foo B 358-363 order
Seq 359-368 Monomer : IID00176 Complex
Region 2f1x B 359-363 order
Region 2f1x B 364-368 disorder
Seq 359-368 Monomer : IID00176 Complex
Region 2f1x A 359-363 order
Region 2f1x A 364-368 disorder
Seq 361-367 Hetero dimer : IID00176 Complex
Region 2foj B 361-367 order
Seq 363-377 Hetero dimer : IID00123 Complex
Region 2mwo B 363-377 order
Seq 365-375 Hetero dimer : IID00329 Complex
Region 3tg5 B 365-367 disorder
Region 3tg5 B 368-375 order
Seq 367-386 Hetero dimer : IID00092 Complex
Region 1jsp A 367-380 disorder
Region 1jsp A 381-385 order
Region 1jsp A 386-386 disorder
Seq 367-388 Hetero tetramer : IID50019 Complex
Region 1dt7 Y 367-388 order
Region 1dt7 X 367-388 order
Seq 369-377 Hetero dimer : IID00128 Complex
Region 1xqh F 369-374 order
Region 1xqh F 375-377 disorder
Region 1xqh B 369-374 order
Region 1xqh B 375-377 disorder
Seq 372-389 Hetero dimer : IID90001 Complex
Region 1ma3 B 372-378 disorder
Region 1ma3 B 379-387 order
Region 1ma3 B 388-389 disorder
Seq 372-389 Hetero dimer : Q8I6E4
Region 5ol0 D 372-377 disorder
Region 5ol0 D 378-386 order
Region 5ol0 D 387-389 disorder
Region 5ol0 C 372-378 disorder
Region 5ol0 C 379-386 order
Region 5ol0 C 387-389 disorder
Seq 372-389 Hetero dimer : IID90011 Complex
Region 1yc5 B 372-372 disorder
Region 1yc5 B 373-385 order
Region 1yc5 B 386-389 disorder
Region 3pdh D 372-372 disorder
Region 3pdh D 373-385 order
Region 3pdh D 386-389 disorder
Region 2h4j D 372-374 disorder
Region 2h4j D 375-385 order
Region 2h4j D 386-389 disorder
Region 2h4h B 372-377 disorder
Region 2h4h B 378-385 order
Region 2h4h B 386-389 disorder
Region 2h4f D 372-377 disorder
Region 2h4f D 378-385 order
Region 2h4f D 386-389 disorder
Region 2h2f B 372-377 disorder
Region 2h2f B 378-384 order
Region 2h2f B 385-389 disorder
Region 2h2d B 372-372 disorder
Region 2h2d B 373-385 order
Region 2h2d B 386-389 disorder
Region 4buz P 379-385 order
Region 4buz P 386-386 disorder
Seq 372-389 Hetero tetramer : IID90011 Complex
Region 4bv2 H 376-379 disorder
Region 4bv2 H 380-384 order
Region 4bv2 H 385-388 disorder
Region 4bv2 E 376-379 disorder
Region 4bv2 E 380-384 order
Region 4bv2 E 385-388 disorder
Region 2h59 E 372-379 disorder
Region 2h59 E 380-385 order
Region 2h59 E 386-389 disorder
Region 2h59 D 372-379 disorder
Region 2h59 D 380-385 order
Region 2h59 D 386-389 disorder
Seq 376-386 Hetero trimer : IID00032 Complex
Region 1h26 E 376-377 disorder
Region 1h26 E 378-386 order
Seq 376-387 Hetero dimer : IID00123 Complex
Region 4x34 D 377-377 disorder
Region 4x34 D 378-385 order
Region 4x34 D 386-386 disorder
Region 4x34 C 377-386 order
Region 2mwp B 376-387 order
Region 3oq5 D 377-386 disorder
Region 3oq5 E 377-386 disorder
Seq 379-383 Hetero dimer : Q96EB6
Region 4zzj B 379-383 order
Seq 382-393 Hetero dimer : IID00301 Complex
Region 5mhc P 382-393 order
Region 5moc P 382-393 order
Seq 385-393 Hetero tetramer : IID00301 Complex
Region 3lw1 P 385-391 order
Region 3lw1 P 392-393 disorder
Seq ProS verified 1-61 : IID50008 Complex
Seq ProS verified 1-61 : IID50008 Complex
Region 5hp0 A 37-61 order
Seq ProS verified 1-61 Hetero dimer : IID00070 Complex
Region 2mzd B 35-59 order
Seq ProS verified 1-61 : IID50008 Complex
Seq ProS verified 1-61 Hetero dimer : IID00070 Complex
Region 2k8f B 15-27 order
Seq ProS verified 1-61 Hetero dimer : IID50008 Complex
Region 2l14 B 13-61 order
Seq ProS verified 14-60 Hetero dimer : IID00297 Complex
Region 2ly4 B 14-60 order
Seq ProS verified 16-29 Hetero dimer : IID50094 Complex
Region 2z5s P 17-27 order
Region 2z5s Q 17-27 order
Region 2z5s R 18-27 order
Region 2z5t P 17-27 order
Region 2z5t Q 17-27 order
Region 2z5t R 17-27 order
Region 3dac B 17-29 order
Region 3dac P 17-28 order
Seq ProS verified 16-29 Hetero dimer : IID00005 Complex
Region 3dab B 17-28 order
Region 3dab D 17-27 order
Region 3dab F 16-27 order
Region 3dab H 18-28 order
Seq ProS verified 17-29 Hetero tetramer : IID50077 Complex
Region 1ycq B 17-27 order
Seq ProS verified 17-29 Hetero dimer : IID00163 Complex
Region 1ycr B 17-29 order
Region 4hfz B 17-27 order
Region 4hfz D 17-27 order
Seq ProS verified 33-56 Hetero hexamer : IID00036 Complex
Region 2b3g B 33-56 order
Seq ProS verified 41-62 Hetero dimer : IID00549 Complex
Region 2ruk A 41-62 order
Seq ProS verified 45-58 Hetero dimer : IID50021 Complex
Region 2gs0 B 45-58 order
Seq ProS possible 358-367
: IID00176 Complex
Region 2f1x A 359-363 order
Seq ProS possible 358-367
Hetero dimer : IID00176 Complex
Region 2foj B 361-367 order
Seq ProS possible 358-367
: IID00176 Complex
Region 2f1x B 359-363 order
Seq ProS possible 358-367
Hetero dimer : IID00176 Complex
Region 2foo B 358-363 order
Seq ProS verified 367-377 Hetero dimer : IID00123 Complex
Region 2mwo B 363-377 order
Seq ProS verified 367-388 Hetero tetramer : IID50019 Complex
Region 1dt7 X 367-388 order
Region 1dt7 Y 367-388 order
Seq ProS verified 368-375 Hetero dimer : IID00329 Complex
Region 3tg5 B 368-375 order
Seq ProS verified 368-375 Hetero dimer : IID00128 Complex
Region 1xqh B 369-374 order
Region 1xqh F 369-374 order
Seq ProS verified 373-387 Hetero dimer : IID90001 Complex
Region 1ma3 B 379-387 order
Seq ProS verified 373-387 Hetero dimer : IID90011 Complex
Region 1yc5 B 373-385 order
Region 2h2d B 373-385 order
Region 2h2f B 378-384 order
Region 2h4f D 378-385 order
Region 2h4h B 378-385 order
Region 2h4j D 375-385 order
Region 3pdh D 373-385 order
Seq ProS verified 373-387 Hetero tetramer : IID90011 Complex
Region 2h59 D 380-385 order
Region 2h59 E 380-385 order
Region 4bv2 E 380-384 order
Region 4bv2 H 380-384 order
Seq ProS verified 376-387 Hetero dimer : IID00123 Complex
Region 2mwp B 376-387 order
Region 4x34 C 377-386 order
Region 4x34 D 378-385 order
Seq ProS verified 378-386 Hetero dimer : Q8I6E4
Region 5ol0 C 379-386 order
Region 5ol0 D 378-386 order
Seq ProS verified 378-386 Hetero trimer : IID00032 Complex
Region 1h26 E 378-386 order
Seq ProS verified 381-385 Hetero dimer : IID00092 Complex
Region 1jsp A 381-385 order
Seq ProS predicted 382-393
Hetero dimer : IID00301 Complex
Region 5mhc P 382-393 order
Region 5moc P 382-393 order
Seq ProS possible 385-391
Hetero tetramer : IID00301 Complex
Region 3lw1 P 385-391 order
392-392 Phosphoserine; by CK2
315-315 Phosphoserine; by AURKA
284-284 Phosphothreonine; by AURKB
269-269 Phosphoserine; by AURKB
183-183 Phosphoserine; by AURKB
55-55 Phosphothreonine; by TAF1 and GRK5
46-46 Phosphoserine; by CDK5
37-37 Phosphoserine; by MAPKAPK5
33-33 Phosphoserine; by CDK5 and CDK7
20-20 Phosphoserine; by CHEK2
18-18 Phosphothreonine; by CK1
9-9 Phosphoserine; by HIPK4
15-15 Phosphoserine; by CDK5
382-382 N6-acetyllysine; by KAT6A; alternate
373-373 N6-acetyllysine; alternate
120-120 N6-acetyllysine; by KAT6A
Prediction
Disorder 1-93,285-321,357-393
Order 94-116,121-243,251-284,322-356
ProS 10-57,285-289,357-363,381-393
Disorder 1-23,26-95,183-183,185-185,293-323,356-393
Order 24-25,96-182,184-184,186-292,324-355
Function
Function in SwissProt
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 (PubMed:12524540). However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP (PubMed:12524540). In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492).
Biological Process
Diagram with PDB data
TP53/EP300 Structural Basis for the Regulation of p53 Function by p300
TP53/CREBBP NMR Structure of CBP Bromodomain in complex with p53 peptide
TP53/SETD7 Crystal structure of a ternary complex of the methyltransferase SET9 (also known as SET7/9) with a P53 peptide and SAH
TP53/SMYD2 Structure of SMYD2 in complex with p53 and SAH
TP53/HMGB1 HMGB1-facilitated p53 DNA binding occurs via HMG-box/p53 transactivation domain interaction and is regulated by the acidic tail
TP53/GTF2H1 Solution structure of the complex between p53 transactivation domain 2 and TFIIH p62 PH domain
TP53/MDM2 Crystal Structure of an MDM2/P53 Peptide Complex
TP53/MDM4 Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain
TP53/S100B SOLUTION STRUCTURE OF THE C-TERMINAL NEGATIVE REGULATORY DOMAIN OF P53 IN A COMPLEX WITH CA2+-BOUND S100B(BB)
TP53/CCNA2 /CDK2 CDK2/CyclinA in complex with an 11-residue recruitment peptide from p53
TP53/SFN Crystal structure of 14-3-3sigma and a p53 C-terminal 12-mer synthetic phosphopeptide
TP53/TP53BP1 Solution structure of 53BP1 tandem Tudor domains in complex with a p53K382me2 peptide
See also
Diagram with PDB data
MDM4/USP7 Crystal Structure of the USP7:HdmX(AHSS) complex
Crebbp/TP53 Structure of CBP nuclear coactivator binding domain in complex with p53 TAD
mdm2 NMR Structure of a Complex Between MDM2 and a Small Molecule Inhibitor
MDM2/USP7 The Crystal Structure of the N-terminal domain of HAUSP/USP7 complexed with mdm2 peptide 147-150
mdm4/TP53 Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain