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IID00085
 UniprotQ16665
ProteinHypoxia-inducible factor 1-alpha
GeneHIF1A
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
826
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 238-348 Hetero dimer : IID00794Complex
 Evidence X-RAY 4h6j A Reference
       Region 4h6j A 238-343 order
       Region 4h6j A 344-348 disorder
Seq 395-411 Hetero dimer : IID00345Complex
 Evidence X-RAY 5la9 C Reference
       Region 5la9 C 395-411 order
 Evidence X-RAY 5la9 D Reference
       Region 5la9 D 395-411 order
Seq 395-411 Hetero tetramer : IID00345Complex
 Evidence X-RAY 5las C Reference
       Region 5las C 395-411 order
 Evidence X-RAY 5las D Reference
       Region 5las D 395-411 order
 Evidence X-RAY 5l9v C Reference
       Region 5l9v C 395-411 order
 Evidence X-RAY 5l9v D Reference
       Region 5l9v D 395-411 order
Seqdisorder 403-698
 Evidence CD Reference
       Region 403-603 disorder
       Region 530-698 disorder
Seq 549-582 Hetero tetramer : IID00371Complex
 Evidence X-RAY 1lm8 H Reference
       Region 1lm8 H 556-560 disorder
       Region 1lm8 H 561-575 order
 Evidence X-RAY 1lqb D Reference
       Region 1lqb D 549-559 disorder
       Region 1lqb D 560-577 order
       Region 1lqb D 578-582 disorder
 Evidence X-RAY 4ajy H Reference
       Region 4ajy H 559-559 disorder
       Region 4ajy H 560-574 order
       Region 4ajy H 575-577 disorder
 Evidence X-RAY 6gfx D Reference
       Region 6gfx D 560-575 order
       Region 6gfx D 576-577 disorder
 Evidence X-RAY 6gmr H Reference
       Region 6gmr H 560-575 order
       Region 6gmr H 576-577 disorder
Seq 556-574 Hetero trimer : IID00345Complex
 Evidence X-RAY 6yw3 S Reference
       Region 6yw3 S 556-557 disorder
       Region 6yw3 S 558-574 order
Seq 556-574 Hetero dimer : IID00345Complex
 Evidence X-RAY 3hqr S Reference
       Region 3hqr S 558-574 order
 Evidence X-RAY 5l9b C Reference
       Region 5l9b C 556-556 disorder
       Region 5l9b C 557-574 order
 Evidence X-RAY 5l9b D Reference
       Region 5l9b D 556-556 disorder
       Region 5l9b D 557-574 order
Seq 558-574 Hetero dimer : IID00345Complex
 Evidence X-RAY 3hqu S Reference
       Region 3hqu S 558-567 disorder
       Region 3hqu S 568-574 order
Seq 717-757 Hetero dimer : IID50009Complex
 Evidence X-RAY 8he0 B Reference
       Region 8he0 B 717-722 order
       Region 8he0 B 723-750 disorder
       Region 8he0 B 751-757 order
Seq 749-757 Hetero dimer : IID50009Complex
 Evidence X-RAY 8he3 B Reference
       Region 8he3 B 749-749 disorder
       Region 8he3 B 750-757 order
Seq 775-826 Hetero tetramer : IID00396Complex
 Evidence X-RAY 1h2k S Reference
       Region 1h2k S 786-794 disorder
       Region 1h2k S 795-806 order
       Region 1h2k S 807-811 disorder
       Region 1h2k S 812-823 order
       Region 1h2k S 824-826 disorder
 Evidence X-RAY 1h2l S Reference
       Region 1h2l S 786-794 disorder
       Region 1h2l S 795-806 order
       Region 1h2l S 807-812 disorder
       Region 1h2l S 813-822 order
       Region 1h2l S 823-826 disorder
 Evidence X-RAY 1h2m S Reference
       Region 1h2m S 775-794 disorder
       Region 1h2m S 795-806 order
       Region 1h2m S 807-812 disorder
       Region 1h2m S 813-822 order
       Region 1h2m S 823-826 disorder
Seqdisorder 776-826
 Evidence NMR Reference
       Region 776-826 disorder
Seq 776-826 Hetero dimer : IID50008Complex
 Evidence NMR 1l8c B Reference
       Region 1l8c B 776-826 order
       Region 1l8c B 776-777 high_rmsd
Seq 786-826 Hetero tetramer : IID00396Complex
 Evidence X-RAY 2ilm S Reference
       Region 2ilm S 786-793 disorder
       Region 2ilm S 794-799 order
       Region 2ilm S 800-826 disorder
Seq 786-826 Hetero dimer : IID00070Complex
 Evidence NMR 1l3e A Reference
       Region 1l3e A 786-826 order
       Region 1l3e A 786-789 high_rmsd
Seq 788-806 Hetero tetramer : IID00396Complex
 Evidence X-RAY 5jwp B Reference
       Region 5jwp B 788-793 disorder
       Region 5jwp B 794-806 order
Seq 794-826 Hetero trimer : IID00070Complex,IID00179Complex
 Evidence X-RAY 7qgs B Reference
       Region 7qgs B 794-826 order
Seq 796-826 Hetero trimer : IID00179Complex,IID50008Complex
 Evidence X-RAY 7lvs F Reference
       Region 7lvs F 796-826 order
SeqProS verified 403-411 Hetero tetramer : IID00345Complex
       Region 5l9v C 395-411 order
       Region 5l9v D 395-411 order
       Region 5las C 395-411 order
       Region 5las D 395-411 order
       Region 403-603 disorder
SeqProS verified 403-411 Hetero dimer : IID00345Complex
       Region 5la9 C 395-411 order
       Region 5la9 D 395-411 order
       Region 403-603 disorder
SeqProS verified 557-577 Hetero dimer : IID00345Complex
       Region 3hqu S 568-574 order
       Region 530-698 disorder
SeqProS verified 557-577 Hetero trimer : IID00345Complex
       Region 6yw3 S 558-574 order
       Region 530-698 disorder
SeqProS verified 557-577 Hetero dimer : IID00345Complex
       Region 3hqr S 558-574 order
       Region 5l9b C 557-574 order
       Region 5l9b D 557-574 order
       Region 530-698 disorder
SeqProS verified 557-577 Hetero tetramer : IID00371Complex
       Region 1lm8 H 561-575 order
       Region 1lqb D 560-577 order
       Region 4ajy H 560-574 order
       Region 6gmr H 560-575 order
       Region 530-698 disorder
SeqProS possible 717-722,751-757 Nuclear Localization Signal Hetero dimer : IID50009Complex
       Region 8he0 B 717-722 order
       Region 8he0 B 751-757 order
SeqProS verified 776-826 Hetero dimer : IID50008Complex
       Region 1l8c B 776-826 order
       Region 776-826 disorder
SeqProS verified 786-826 Hetero dimer : IID00070Complex
       Region 1l3e A 786-826 order
       Region 776-826 disorder
SeqProS verified 794-806 Hetero tetramer : IID00396Complex
       Region 2ilm S 794-799 order
       Region 776-826 disorder
SeqProS verified 794-806 Hetero tetramer : IID00396Complex
       Region 5jwp B 794-806 order
       Region 776-826 disorder
SeqProS verified 794-806,812-823 Hetero tetramer : IID00396Complex
       Region 1h2m S 795-806 order
       Region 1h2k S 795-806 order
       Region 1h2l S 795-806 order
       Region 1h2m S 813-822 order
       Region 1h2k S 812-823 order
       Region 1h2l S 813-822 order
       Region 776-826 disorder
SeqProS verified 794-826 Hetero trimer : IID00070Complex,IID00179Complex
       Region 7qgs B 794-826 order
       Region 776-826 disorder
SeqProS verified 794-826 Hetero trimer : IID00179Complex,IID50008Complex
       Region 7lvs F 796-826 order
       Region 776-826 disorder
Seqphosphorylation
    657-657 Phosphoserine; by PLK3
    589-589 Phosphoserine; by GSK3-beta
    576-576 Phosphoserine; by PLK3
    555-555 Phosphothreonine; by GSK3-beta
    551-551 Phosphoserine; by GSK3-beta
    247-247 Phosphoserine; by CK1
Seqacetylation
    709-709 N6-acetyllysine
    532-532 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-29,152-162,180-187,202-206,351-787
Order 30-151,163-179,188-201,208-350,788-826
ProS 9-29,180-187,351-356,384-415,425-435,456-461,486-489,517-542,554-579,633-636,644-647,703-714,720-725,751-756,768-787
AlphaFold
Disorder 1-9,75-82,84-84,151-161,203-215,359-386,390-390,396-402,404-404,407-826
Order 10-74,83-83,85-150,162-202,216-358,387-389,391-395,403-403,405-406
Pfam Hmmer
PF08447 252-345 2.2e-26
SEG 10-35 ,579-597 ,611-621
Function
Function in SwissProt
(Microbial infection) Upon infection by human coronavirus SARS-CoV-2, is required for induction of glycolysis in monocytes and the consequent pro-inflammatory state (PubMed:32697943). In monocytes, induces expression of ACE2 and cytokines such as IL1B, TNF, IL6, and interferons (PubMed:32697943). Promotes human coronavirus SARS-CoV-2 replication and monocyte inflammatory response (PubMed:32697943).
Biological Process
Diagram with PDB data
HIF1A/VHL/ELOB/ELOCCrystal structure of a hydroxylated HIF-1 alpha peptide bound to the pVHL/elongin-C/elongin-B complex
HIF1A/HIF1ANFactor Inhibiting HIF-1 alpha in complex with HIF-1 alpha fragment peptide
HIF1A/EP300NMR Structures of the HIF-1alpha CTAD/p300 CH1 Complex
See also
Diagram with PDB data
CITED2/EP300Structural basis for negative regulation of hypoxia-inducible factor-1alpha by CITED2