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IID00165
 UniprotQ05195
ProteinMax dimerization protein 1
GeneMXD1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
221
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 5-28 Hetero dimer : IID50092Complex
 Evidence NMR 1pd7 B Reference
       Region 1pd7 B 5-28 order
       Region 1pd7 B 5-5 high_rmsd
Seq 6-21 Hetero dimer : IID50089Complex
 Evidence NMR 1g1e A Reference
       Region 1g1e A 6-21 order
       Region 1g1e A 6-6 high_rmsd
 Evidence NMR 1s5q A Reference
       Region 1s5q A 6-21 order
Seq 8-20 Hetero dimer : IID50092Complex
 Evidence NMR 1e91 B Reference
       Region 1e91 B 8-20 order
Seqdisorder 8-20
 Evidence CD Reference
       Region 8-20 disorder
Seq 57-136 Hetero dimer : P61244
 Evidence X-RAY 1nlw A Reference
       Region 1nlw A 57-135 order
       Region 1nlw A 136-136 disorder
 Evidence X-RAY 1nlw D Reference
       Region 1nlw D 57-133 order
       Region 1nlw D 134-136 disorder
SeqProS verified 5-28 Hetero dimer : IID50092Complex
       Region 1e91 B 8-20 order
       Region 8-20 disorder
SeqProS verified 5-28 Hetero dimer : IID50092Complex
       Region 1pd7 B 5-28 order
       Region 8-20 disorder
SeqProS verified 6-21 Hetero dimer : IID50089Complex
       Region 1s5q A 6-21 order
       Region 1g1e A 6-21 order
       Region 8-20 disorder
 
Prediction
NeProc
Disorder 1-4,13-67,147-221
Order 5-12,68-146
ProS 13-42,54-67,147-150,173-178,186-211,218-221
AlphaFold
Disorder 1-1,23-54,88-90,139-163,168-221
Order 2-22,55-87,91-138,164-167
Pfam Hmmer
PF00010 57-109 6.1e-14
SEG 45-59 ,150-168 ,175-187
Function
Function in SwissProt
Component of a transcriptional repressor complex together with MAX (PubMed:8425218). In complex with MAX binds to the core DNA sequence 5'-CAC[GA]TG-3' (PubMed:8425218). Antagonizes MYC transcriptional activity by competing with MYC for MAX binding (PubMed:8425218). Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding (PubMed:12837246).
Biological Process
Diagram with PDB data
MXD1/Sin3bStructure of the complex of the Mad1-Sin3B interaction domains