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IID00196
 UniprotP23025
ProteinDNA repair protein complementing XP-A cells
GeneXPA
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
273
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seqdisorder 67-80
 Evidence NMR Reference
       Region 67-80 disorder
Seq 67-80 Hetero dimer : IID00364Complex
 Evidence NMR 2jnw B Reference
       Region 2jnw B 67-77 order
       Region 2jnw B 78-80 disorder
Seq 98-239 Homo dimer :
 Evidence X-RAY 6lae A Reference
       Region 6lae A 98-100 disorder
       Region 6lae A 101-216 order
       Region 6lae A 217-239 disorder
 Evidence X-RAY 6lae B Reference
       Region 6lae B 98-100 disorder
       Region 6lae B 101-216 order
       Region 6lae B 217-239 disorder
Seq 98-239 Monomer :
 Evidence NMR 1d4u A Reference
       Region 1d4u A 98-208 order
 Evidence NMR 1xpa A Reference
       Region 1xpa A 98-165 order
       Region 1xpa A 166-179 disorder
       Region 1xpa A 180-210 order
       Region 1xpa A 211-219 disorder
 Evidence X-RAY 6j44 A Reference
       Region 6j44 A 98-168 order
       Region 6j44 A 169-176 disorder
       Region 6j44 A 177-231 order
       Region 6j44 A 232-239 disorder
SeqProS verified 67-77 Hetero dimer : IID00364Complex
       Region 2jnw B 67-77 order
       Region 67-80 disorder
Seqphosphorylation
    196-196 Phosphoserine
Seqacetylation
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-65,75-95,228-245
Order 66-74,96-227,246-273
ProS 27-65,75-95,228-245
AlphaFold
Disorder 1-18,47-69,75-100,234-241
Order 19-46,70-74,101-233,242-273
Pfam Hmmer
PF01286 100-133 1.1e-20
PF05181 134-186 3.4e-36
SEG 2-22 ,30-65 ,78-84 ,213-224
Function
Function in SwissProt
Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation.
Biological Process
Diagram with PDB data
XPA/ERCC1Solution structure of a ERCC1-XPA heterodimer