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IID00222
 UniprotQ99081
ProteinTranscription factor 12
GeneTCF12
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
682
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 11-28 Hetero dimer : IID00381Complex
 Evidence NMR 2knh B Reference
       Region 2knh B 11-28 order
Seq 177-200 Hetero tetramer : IID00381Complex
 Evidence X-RAY 4jol E Reference
       Region 4jol E 177-185 disorder
       Region 4jol E 186-196 order
       Region 4jol E 197-200 disorder
 Evidence X-RAY 4jol F Reference
       Region 4jol F 177-185 disorder
       Region 4jol F 186-196 order
       Region 4jol F 197-200 disorder
 Evidence X-RAY 4jol G Reference
       Region 4jol G 177-185 disorder
       Region 4jol G 186-196 order
       Region 4jol G 197-200 disorder
 Evidence X-RAY 4jol H Reference
       Region 4jol H 177-184 disorder
       Region 4jol H 185-196 order
       Region 4jol H 197-200 disorder
SeqProS possible 11-28 LXXLL motif Hetero dimer : IID00381Complex
       Region 2knh B 11-28 order
Seqphosphorylation
    98-98 Phosphoserine
    47-47 Phosphoserine
    67-67 Phosphoserine
    79-79 Phosphoserine
    313-313 Phosphothreonine
    116-116 Phosphoserine
    559-559 Phosphoserine
    558-558 Phosphoserine
    557-557 Phosphothreonine
    540-540 Phosphoserine
    333-333 Phosphoserine
 
Prediction
NeProc
Disorder 1-582,648-682
Order 583-647
ProS 8-39,104-142,181-210,221-229,235-240,274-280,320-327,371-379,389-393,404-417,494-502,524-534,547-582,674-682
AlphaFold
Disorder 1-14,25-25,28-335,344-344,347-395,419-565,640-682
Order 15-24,26-27,336-343,345-346,396-418,566-639
Pfam Hmmer
PF00010 578-631 2.4e-12
SEG 208-219 ,256-265 ,352-363 ,445-464 ,481-492 ,534-548 ,661-672
Function
Function in SwissProt
Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3').