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IID00239
 UniprotP84243
ProteinHistone H3.3
GeneH3-3A
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
136
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-134 Hetero octamer : IID00016Complex,IID00058Complex
 Evidence X-RAY 5ay8 E Reference
       Region 5ay8 E 1-38 disorder
       Region 5ay8 E 39-134 order
 Evidence X-RAY 5ay8 A Reference
       Region 5ay8 A 1-38 disorder
       Region 5ay8 A 39-134 order
Seq 1-136 Hetero trimer : IID00058Complex,IID00398Complex
 Evidence X-RAY 4hga B Reference
       Region 4hga B 1-43 disorder
       Region 4hga B 44-136 order
 Evidence X-RAY 4h9s B Reference
       Region 4h9s B 2-40 disorder
       Region 4h9s B 41-134 order
       Region 4h9s B 135-136 disorder
 Evidence X-RAY 4h9s A Reference
       Region 4h9s A 2-45 disorder
       Region 4h9s A 46-134 order
       Region 4h9s A 135-136 disorder
 Evidence X-RAY 4h9r A Reference
       Region 4h9r A 2-37 disorder
       Region 4h9r A 38-135 order
       Region 4h9r A 136-136 disorder
 Evidence X-RAY 4h9q A Reference
       Region 4h9q A 2-37 disorder
       Region 4h9q A 38-135 order
       Region 4h9q A 136-136 disorder
 Evidence X-RAY 4h9p A Reference
       Region 4h9p A 2-37 disorder
       Region 4h9p A 38-135 order
       Region 4h9p A 136-136 disorder
 Evidence X-RAY 4h9o A Reference
       Region 4h9o A 2-38 disorder
       Region 4h9o A 39-135 order
       Region 4h9o A 136-136 disorder
 Evidence X-RAY 4h9n A Reference
       Region 4h9n A 2-37 disorder
       Region 4h9n A 38-135 order
       Region 4h9n A 136-136 disorder
Seq 1-136 Hetero octamer : IID00016Complex,IID00058Complex,IID00272Complex
 Evidence X-RAY 3wtp E Reference
       Region 3wtp E 1-36 disorder
       Region 3wtp E 37-136 order
Seq 1-136 Hetero octamer : IID00016Complex,IID00058Complex
 Evidence X-RAY 5x7x E Reference
       Region 5x7x E 1-36 disorder
       Region 5x7x E 37-135 order
       Region 5x7x E 136-136 disorder
 Evidence X-RAY 5x7x A Reference
       Region 5x7x A 1-38 disorder
       Region 5x7x A 39-134 order
       Region 5x7x A 135-136 disorder
Seq 1-136 Hetero octamer : IID00016Complex,IID00019Complex,IID00058Complex
 Evidence X-RAY 5b32 E Reference
       Region 5b32 E 1-38 disorder
       Region 5b32 E 39-136 order
 Evidence X-RAY 5b32 A Reference
       Region 5b32 A 1-38 disorder
       Region 5b32 A 39-135 order
       Region 5b32 A 136-136 disorder
Seq 1-136 Hetero octamer : IID00019Complex,IID00058Complex
 Evidence X-RAY 5b33 E Reference
       Region 5b33 E 1-38 disorder
       Region 5b33 E 39-136 order
 Evidence X-RAY 5b33 A Reference
       Region 5b33 A 1-38 disorder
       Region 5b33 A 39-135 order
       Region 5b33 A 136-136 disorder
Seq 1-136 Hetero octamer : IID00016Complex,IID00058Complex
 Evidence X-RAY 3av2 E Reference
       Region 3av2 E 1-38 disorder
       Region 3av2 E 39-136 order
 Evidence X-RAY 3av2 A Reference
       Region 3av2 A 1-38 disorder
       Region 3av2 A 39-135 order
       Region 3av2 A 136-136 disorder
Seq 2-12 Hetero dimer : IID00327Complex
 Evidence X-RAY 3asl B Reference
       Region 3asl B 2-10 order
       Region 3asl B 11-12 disorder
Seq 2-12 Hetero tetramer : Q504Y3
 Evidence X-RAY 4o62 D Reference
       Region 4o62 D 2-7 order
       Region 4o62 D 8-12 disorder
Seq 2-12 Hetero dimer : IID00552Complex
 Evidence X-RAY 4tmp D Reference
       Region 4tmp D 2-3 disorder
       Region 4tmp D 4-11 order
       Region 4tmp D 12-12 disorder
 Evidence X-RAY 4tmp B Reference
       Region 4tmp B 2-3 disorder
       Region 4tmp B 4-11 order
       Region 4tmp B 12-12 disorder
Seq 2-13 Hetero dimer : IID00485Complex
 Evidence X-RAY 4l58 B Reference
       Region 4l58 B 2-8 order
       Region 4l58 B 9-13 disorder
Seq 2-13 Hetero hexamer : IID00336Complex
 Evidence X-RAY 4u7t G Reference
       Region 4u7t G 2-11 order
       Region 4u7t G 12-13 disorder
 Evidence X-RAY 4u7t F Reference
       Region 4u7t F 2-11 order
       Region 4u7t F 12-13 disorder
Seq 2-13 Monomer : O95696
 Evidence NMR 2l43 A Reference
       Region 2l43 A 2-13 order
       Region 2l43 A 10-13 high_rmsd
Seq 2-14
 Evidence X-RAY 3ask R The all of the chain R is disordered but K9 is ordered. Reference
       Region 3ask R 2-9 disorder
       Region 3ask R 10-10 order
       Region 3ask R 11-14 disorder
Seq 2-16 Hetero dimer : IID00303Complex
 Evidence X-RAY 4w5a F Reference
       Region 4w5a F 2-12 order
       Region 4w5a F 13-16 disorder
 Evidence X-RAY 4w5a D Reference
       Region 4w5a D 2-13 order
       Region 4w5a D 14-16 disorder
 Evidence X-RAY 4w5a C Reference
       Region 4w5a C 2-12 order
       Region 4w5a C 13-16 disorder
 Evidence X-RAY 3qlc D Reference
       Region 3qlc D 2-8 order
       Region 3qlc D 9-16 disorder
 Evidence X-RAY 3qlc C Reference
       Region 3qlc C 2-8 order
       Region 3qlc C 9-16 disorder
 Evidence X-RAY 3qla F Reference
       Region 3qla F 2-11 order
       Region 3qla F 12-16 disorder
 Evidence X-RAY 3qla C Reference
       Region 3qla C 2-11 order
       Region 3qla C 12-16 disorder
 Evidence X-RAY 3ql9 C Reference
       Region 3ql9 C 2-11 order
       Region 3ql9 C 12-16 disorder
Seq 2-16 Hetero dimer : IID00496Complex
 Evidence X-RAY 4gng F Reference
       Region 4gng F 2-11 order
       Region 4gng F 12-16 disorder
 Evidence X-RAY 4gng B Reference
       Region 4gng B 2-11 order
       Region 4gng B 12-16 disorder
 Evidence X-RAY 4gnf C Reference
       Region 4gnf C 2-10 order
       Region 4gnf C 11-16 disorder
 Evidence X-RAY 4gne B Reference
       Region 4gne B 2-7 order
       Region 4gne B 8-8 disorder
Seq 2-16 Hetero tetramer : Q14149
 Evidence X-RAY 4qq4 C Reference
       Region 4qq4 C 2-9 order
       Region 4qq4 C 10-16 disorder
 Evidence X-RAY 4qq4 D Reference
       Region 4qq4 D 2-9 order
       Region 4qq4 D 10-16 disorder
Seq 2-18 Hetero hexamer : IID00327Complex
 Evidence X-RAY 4gy5 F Reference
       Region 4gy5 F 2-10 order
       Region 4gy5 F 11-18 disorder
 Evidence X-RAY 4gy5 E Reference
       Region 4gy5 E 2-11 order
       Region 4gy5 E 12-18 disorder
 Evidence X-RAY 3ask Q The all of the chain R is disordered but K9 is ordered. Reference
       Region 3ask Q 2-10 order
       Region 3ask Q 11-14 disorder
 Evidence X-RAY 3ask P The all of the chain R is disordered but K9 is ordered. Reference
       Region 3ask P 2-11 order
       Region 3ask P 12-14 disorder
Seq 2-22 Hetero trimer : IID00487Complex
 Evidence X-RAY 4gus C Reference
       Region 4gus C 2-21 order
       Region 4gus C 22-22 disorder
 Evidence X-RAY 4gur C Reference
       Region 4gur C 2-21 order
       Region 4gur C 22-22 disorder
Seq 2-27 Hetero trimer : IID00487Complex
 Evidence X-RAY 4gu0 F Reference
       Region 4gu0 F 2-27 order
 Evidence X-RAY 4gu0 E Reference
       Region 4gu0 E 2-27 order
Seq 2-136 Hetero tetramer : IID00058Complex,IID00398Complex,Q1HVJ0
 Evidence X-RAY 5kdm A Reference
       Region 5kdm A 2-37 disorder
       Region 5kdm A 38-136 order
Seq 13-20 Hetero dimer : IID50100Complex
 Evidence X-RAY 3mul D Reference
       Region 3mul D 13-15 order
       Region 3mul D 16-20 disorder
 Evidence X-RAY 3jvk C Reference
       Region 3jvk C 13-16 order
       Region 3jvk C 17-20 disorder
Seq 14-31 Hetero trimer : Q86X55
 Evidence X-RAY 5dwq G Reference
       Region 5dwq G 14-21 order
       Region 5dwq G 22-31 disorder
 Evidence X-RAY 5dwq F Reference
       Region 5dwq F 14-22 order
       Region 5dwq F 23-31 disorder
Seq 14-31 Hetero tetramer : Q86X55
 Evidence X-RAY 5dx0 I Reference
       Region 5dx0 I 14-22 order
       Region 5dx0 I 23-31 disorder
 Evidence X-RAY 5dx0 H Reference
       Region 5dx0 H 14-21 order
       Region 5dx0 H 22-31 disorder
 Evidence X-RAY 5dx0 G Reference
       Region 5dx0 G 14-22 order
       Region 5dx0 G 23-31 disorder
 Evidence X-RAY 5dx0 F Reference
       Region 5dx0 F 14-21 order
       Region 5dx0 F 22-31 disorder
Seq 20-43 Hetero dimer : Q8R5C8
 Evidence X-RAY 4n4i B Reference
       Region 4n4i B 20-29 disorder
       Region 4n4i B 30-40 order
       Region 4n4i B 41-43 disorder
Seq 22-29 Hetero dimer : IID50100Complex
 Evidence X-RAY 3muk D Reference
       Region 3muk D 22-28 order
       Region 3muk D 29-29 disorder
Seq 30-43 Hetero dimer : Q9BYW2
 Evidence X-RAY 5jlb B Reference
       Region 5jlb B 30-43 order
 Evidence X-RAY 5jjy B Reference
       Region 5jjy B 30-43 order
Seq 58-136 Hetero hexamer : IID00058Complex,IID00715Complex
 Evidence X-RAY 5bnv D Reference
       Region 5bnv D 58-58 disorder
       Region 5bnv D 59-136 order
 Evidence X-RAY 5bnv A Reference
       Region 5bnv A 58-58 disorder
       Region 5bnv A 59-135 order
       Region 5bnv A 136-136 disorder
Seq 58-136 Hetero tetramer : IID00058Complex,IID00715Complex,Q9NVP2
 Evidence X-RAY 5bnx A Reference
       Region 5bnx A 58-58 disorder
       Region 5bnx A 59-135 order
       Region 5bnx A 136-136 disorder
Seq 58-136 Hetero octamer : IID00058Complex,IID00715Complex,Q96HA7
 Evidence X-RAY 5ja4 A Reference
       Region 5ja4 A 58-135 order
       Region 5ja4 A 136-136 disorder
SeqProS verified 2-7 Hetero tetramer : Q504Y3
       Region 4o62 D 2-7 order
       Region 3av2 A 1-38 disorder
SeqProS verified 2-9 Hetero tetramer : Q14149
       Region 4qq4 C 2-9 order
       Region 4qq4 D 2-9 order
       Region 3av2 A 1-38 disorder
SeqProS verified 2-10 Hetero dimer : IID00327Complex
       Region 3asl B 2-10 order
       Region 3av2 A 1-38 disorder
SeqProS verified 2-11 Hetero hexamer : IID00336Complex
       Region 4u7t F 2-11 order
       Region 4u7t G 2-11 order
       Region 3av2 A 1-38 disorder
SeqProS verified 2-13 Hetero dimer : IID00303Complex
       Region 4w5a C 2-12 order
       Region 4w5a D 2-13 order
       Region 4w5a F 2-12 order
       Region 3ql9 C 2-11 order
       Region 3qla C 2-11 order
       Region 3qla F 2-11 order
       Region 3qlc C 2-8 order
       Region 3qlc D 2-8 order
       Region 3av2 A 1-38 disorder
SeqProS verified 2-21 The Lys-9 is trimethyl-Lysine. This region is ordered in the complex with UHRF1. Hetero hexamer : IID00327Complex
       Region 4gy5 E 2-11 order
       Region 4gy5 F 2-10 order
       Region 3ask P 2-11 order
       Region 3ask Q 2-10 order
       Region 3av2 A 1-38 disorder
SeqProS verified 2-21 Hetero trimer : IID00487Complex
       Region 4gur C 2-21 order
       Region 4gus C 2-21 order
       Region 3av2 A 1-38 disorder
SeqProS verified 2-21 Hetero dimer : IID00485Complex
       Region 4l58 B 2-8 order
       Region 3av2 A 1-38 disorder
SeqProS verified 2-21 Hetero dimer : IID00496Complex
       Region 4gnf C 2-10 order
       Region 4gne B 2-7 order
       Region 4gng B 2-11 order
       Region 4gng F 2-11 order
       Region 3av2 A 1-38 disorder
SeqProS verified 2-27 Hetero trimer : IID00487Complex
       Region 4gu0 E 2-27 order
       Region 4gu0 F 2-27 order
       Region 3av2 A 1-38 disorder
SeqProS verified 4-11 Hetero dimer : IID00552Complex
       Region 4tmp B 4-11 order
       Region 4tmp D 4-11 order
       Region 3av2 A 1-38 disorder
SeqProS verified 13-16 Histone H3K23 is propionyl lysine Hetero dimer : IID50100Complex
       Region 3jvk C 13-16 order
       Region 3mul D 13-15 order
       Region 3av2 A 1-38 disorder
SeqProS verified 14-22 Hetero tetramer : Q86X55
       Region 5dx0 F 14-21 order
       Region 5dx0 G 14-22 order
       Region 5dx0 H 14-21 order
       Region 5dx0 I 14-22 order
       Region 3av2 A 1-38 disorder
SeqProS verified 14-22 Hetero trimer : Q86X55
       Region 5dwq F 14-22 order
       Region 5dwq G 14-21 order
       Region 3av2 A 1-38 disorder
SeqProS verified 22-28 Histone H3K23 is propionyl lysine. Hetero dimer : IID50100Complex
       Region 3muk D 22-28 order
       Region 3av2 A 1-38 disorder
SeqProS verified 30-38 Hetero dimer : Q8R5C8
       Region 4n4i B 30-40 order
       Region 3av2 A 1-38 disorder
SeqProS verified 30-38 Hetero dimer : Q9BYW2
       Region 5jlb B 30-43 order
       Region 5jjy B 30-43 order
       Region 3av2 A 1-38 disorder
Seqphosphorylation
    4-4 Phosphothreonine; by HASPIN
    7-7 Phosphothreonine; by PKC
    11-11 Phosphoserine; alternate; by AURKB
    12-12 Phosphothreonine; by PKC
    29-29 Phosphoserine; alternate; by AURKB
    32-32 Phosphoserine
    42-42 Phosphotyrosine
    58-58 Phosphoserine
    81-81 Phosphothreonine
    87-87 Phosphoserine
    108-108 Phosphothreonine
Seqacetylation
    5-5 N6-acetyllysine; alternate
    10-10 N6-acetyllysine; alternate
    15-15 N6-acetyllysine; alternate
    19-19 N6-acetyllysine; alternate
    24-24 N6-acetyllysine; alternate
    28-28 N6-acetyllysine; alternate
    37-37 N6-acetyllysine; alternate
    57-57 N6-acetyllysine; alternate
    80-80 N6-acetyllysine; alternate
    116-116 N6-acetyllysine; alternate
    123-123 N6-acetyllysine; alternate
 
Prediction
NeProc
Disorder 1-39
Order 40-136
ProS 1-39
AlphaFold
Disorder 1-3,7-35,135-136
Order 4-6,36-134
Pfam Hmmer
PF00125 58-132 2.1e-40
Function
Function in SwissProt
Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Biological Process
See also
Diagram with PDB data
UHRF1Crystal structure of UHRF1 TTD domain in complex with the polybasic region