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IID00301
 UniprotP31947
Protein14-3-3 protein sigma
GeneSFN
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
248
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-231 Hetero tetramer : Q6TGC4
 Evidence X-RAY 4dat A Reference
       Region 4dat A 1-67 order
       Region 4dat A 68-77 disorder
       Region 4dat A 78-136 order
       Region 4dat A 137-139 disorder
       Region 4dat A 140-231 order
Seq 1-231 Homo dimer : P08151
 Evidence X-RAY 5om0 B Reference
       Region 5om0 B 1-1 disorder
       Region 5om0 B 2-71 order
       Region 5om0 B 72-77 disorder
       Region 5om0 B 78-108 order
       Region 5om0 B 109-111 disorder
       Region 5om0 B 112-207 order
       Region 5om0 B 208-209 disorder
       Region 5om0 B 210-230 order
       Region 5om0 B 231-231 disorder
 Evidence X-RAY 5om0 A Reference
       Region 5om0 A 1-71 order
       Region 5om0 A 72-76 disorder
       Region 5om0 A 77-231 order
Seq 1-231 Hetero tetramer :
 Evidence X-RAY 6fbb A Reference
       Region 6fbb A 1-71 order
       Region 6fbb A 72-72 disorder
       Region 6fbb A 73-136 order
       Region 6fbb A 137-139 disorder
       Region 6fbb A 140-231 order
Seq 1-231 Hetero dimer : IID00015Complex
 Evidence X-RAY 5mhc A Reference
       Region 5mhc A 1-71 order
       Region 5mhc A 72-72 disorder
       Region 5mhc A 73-231 order
 Evidence X-RAY 5moc A Reference
       Region 5moc A 1-70 order
       Region 5moc A 71-77 disorder
       Region 5moc A 78-136 order
       Region 5moc A 137-138 disorder
       Region 5moc A 139-231 order
Seq 1-231 Hetero tetramer : Q9NPC2
 Evidence X-RAY 3ux0 A Reference
       Region 3ux0 A 1-70 order
       Region 3ux0 A 71-77 disorder
       Region 3ux0 A 78-231 order
 Evidence X-RAY 3spr A Reference
       Region 3spr A 1-231 order
 Evidence X-RAY 3sp5 A Reference
       Region 3sp5 A 1-231 order
 Evidence X-RAY 3smo A Reference
       Region 3smo A 1-231 order
 Evidence X-RAY 3smn A Reference
       Region 3smn A 1-231 order
 Evidence X-RAY 3smm A Reference
       Region 3smm A 1-231 order
 Evidence X-RAY 3sml A Reference
       Region 3sml A 1-231 order
 Evidence X-RAY 3smk A Reference
       Region 3smk A 1-70 order
       Region 3smk A 71-77 disorder
       Region 3smk A 78-208 order
       Region 3smk A 209-212 disorder
       Region 3smk A 213-231 order
 Evidence X-RAY 3p1s A Reference
       Region 3p1s A 1-231 order
 Evidence X-RAY 3p1r A Reference
       Region 3p1r A 1-231 order
 Evidence X-RAY 3p1q A Reference
       Region 3p1q A 1-231 order
 Evidence X-RAY 3p1p A Reference
       Region 3p1p A 1-231 order
 Evidence X-RAY 3p1o A Reference
       Region 3p1o A 1-231 order
 Evidence X-RAY 3p1n A Reference
       Region 3p1n A 1-231 order
 Evidence X-RAY 4fr3 A Reference
       Region 4fr3 A 1-70 order
       Region 4fr3 A 71-76 disorder
       Region 4fr3 A 77-77 order
       Region 4fr3 A 79-231 order
Seq 1-231 Homo dimer : O14558
 Evidence X-RAY 5ok9 E Reference
       Region 5ok9 E 1-71 order
       Region 5ok9 E 72-76 disorder
       Region 5ok9 E 77-231 order
 Evidence X-RAY 5ok9 F Reference
       Region 5ok9 F 1-70 order
       Region 5ok9 F 71-75 disorder
       Region 5ok9 F 76-231 order
Seq 1-231 Hetero tetramer : Q5S007
 Evidence X-RAY 5my9 A Reference
       Region 5my9 A 1-231 order
Seq 1-231 Hetero tetramer : IID00292Complex
 Evidence X-RAY 4iea A Reference
       Region 4iea A 1-71 order
       Region 4iea A 72-76 disorder
       Region 4iea A 77-231 order
Seq 1-231 Hetero tetramer : IID00363Complex
 Evidence X-RAY 4qli A Reference
       Region 4qli A 1-231 order
Seq 1-231 Homo dimer : O14558
 Evidence X-RAY 5ok9 A Reference
       Region 5ok9 A 1-70 order
       Region 5ok9 A 71-77 disorder
       Region 5ok9 A 78-231 order
 Evidence X-RAY 5ok9 B Reference
       Region 5ok9 B 1-71 order
       Region 5ok9 B 72-75 disorder
       Region 5ok9 B 76-231 order
Seq 1-231 Hetero dimer : P49675
 Evidence X-RAY 5oma D Reference
       Region 5oma D 1-1 disorder
       Region 5oma D 2-72 order
       Region 5oma D 73-77 disorder
       Region 5oma D 78-231 order
 Evidence X-RAY 5oma B Reference
       Region 5oma B 1-74 order
       Region 5oma B 75-77 disorder
       Region 5oma B 78-231 order
Seq 1-231 Hetero tetramer : IID00013Complex
 Evidence X-RAY 4jdd A Reference
       Region 4jdd A 1-231 order
 Evidence X-RAY 4jc3 A Reference
       Region 4jc3 A 1-231 order
Seq 1-231 Hetero tetramer : P10636
 Evidence X-RAY 5hf3 A Reference
       Region 5hf3 A 1-71 order
       Region 5hf3 A 72-72 disorder
       Region 5hf3 A 73-73 order
       Region 5hf3 A 74-76 disorder
       Region 5hf3 A 77-136 order
       Region 5hf3 A 137-137 disorder
       Region 5hf3 A 138-231 order
 Evidence X-RAY 4fl5 B Reference
       Region 4fl5 B 1-70 order
       Region 4fl5 B 71-77 disorder
       Region 4fl5 B 78-231 order
 Evidence X-RAY 4fl5 A Reference
       Region 4fl5 A 1-70 order
       Region 4fl5 A 71-76 disorder
       Region 4fl5 A 77-231 order
Seq 1-231 Hetero dimer : Q5S007
 Evidence X-RAY 5myc A Reference
       Region 5myc A 1-231 order
Seq 1-231 Hetero dimer : Q9GZV5
 Evidence X-RAY 5n5r A Reference
       Region 5n5r A 1-71 order
       Region 5n5r A 72-77 disorder
       Region 5n5r A 78-231 order
Seq 1-231 Monomer :
 Evidence X-RAY 5oeh A Reference
       Region 5oeh A 1-70 order
       Region 5oeh A 71-76 disorder
       Region 5oeh A 77-231 order
 Evidence X-RAY 5oeg A Reference
       Region 5oeg A 1-70 order
       Region 5oeg A 71-77 disorder
       Region 5oeg A 78-231 order
 Evidence X-RAY 5mxo A Reference
       Region 5mxo A 1-70 order
       Region 5mxo A 71-77 disorder
       Region 5mxo A 78-136 order
       Region 5mxo A 137-138 disorder
       Region 5mxo A 139-209 order
       Region 5mxo A 210-213 disorder
       Region 5mxo A 214-231 order
 Evidence X-RAY 5btv A Reference
       Region 5btv A 1-70 order
       Region 5btv A 71-77 disorder
       Region 5btv A 78-231 order
Seq 1-231 Homo dimer : O14558
 Evidence X-RAY 5okf C Reference
       Region 5okf C 1-71 order
       Region 5okf C 72-76 disorder
       Region 5okf C 77-208 order
       Region 5okf C 209-212 disorder
       Region 5okf C 213-231 order
 Evidence X-RAY 5okf D Reference
       Region 5okf D 1-70 order
       Region 5okf D 71-77 disorder
       Region 5okf D 78-206 order
       Region 5okf D 207-212 disorder
       Region 5okf D 213-231 order
Seq 1-231 Hetero tetramer : P10636
 Evidence X-RAY 4y3b B Reference
       Region 4y3b B 1-70 order
       Region 4y3b B 71-71 disorder
       Region 4y3b B 72-72 order
       Region 4y3b B 73-73 disorder
       Region 4y3b B 74-231 order
 Evidence X-RAY 4y3b A Reference
       Region 4y3b A 1-70 order
       Region 4y3b A 71-76 disorder
       Region 4y3b A 77-137 order
       Region 4y3b A 138-138 disorder
       Region 4y3b A 139-231 order
 Evidence X-RAY 4y32 B Reference
       Region 4y32 B 1-137 order
       Region 4y32 B 138-138 disorder
       Region 4y32 B 139-231 order
 Evidence X-RAY 4y32 A Reference
       Region 4y32 A 1-137 order
       Region 4y32 A 138-138 disorder
       Region 4y32 A 139-231 order
 Evidence X-RAY 4y5i B Reference
       Region 4y5i B 1-69 order
       Region 4y5i B 70-75 disorder
       Region 4y5i B 76-76 order
       Region 4y5i B 77-77 disorder
       Region 4y5i B 78-230 order
       Region 4y5i B 231-231 disorder
 Evidence X-RAY 4y5i A Reference
       Region 4y5i A 1-70 order
       Region 4y5i A 71-77 disorder
       Region 4y5i A 78-109 order
       Region 4y5i A 110-111 disorder
       Region 4y5i A 112-231 order
Seq 1-231 Homo dimer : O14558
 Evidence X-RAY 5okf A Reference
       Region 5okf A 1-70 order
       Region 5okf A 71-76 disorder
       Region 5okf A 77-137 order
       Region 5okf A 138-138 disorder
       Region 5okf A 139-208 order
       Region 5okf A 209-209 disorder
       Region 5okf A 210-231 order
 Evidence X-RAY 5okf B Reference
       Region 5okf B 1-71 order
       Region 5okf B 72-77 disorder
       Region 5okf B 78-206 order
       Region 5okf B 207-212 disorder
       Region 5okf B 213-231 order
Seq 1-231 Hetero tetramer : O14558
 Evidence X-RAY 5ltw J Reference
       Region 5ltw J 1-71 order
       Region 5ltw J 72-74 disorder
       Region 5ltw J 75-231 order
 Evidence X-RAY 5ltw I Reference
       Region 5ltw I 1-231 order
 Evidence X-RAY 5ltw F Reference
       Region 5ltw F 1-71 order
       Region 5ltw F 72-74 disorder
       Region 5ltw F 75-231 order
 Evidence X-RAY 5ltw E Reference
       Region 5ltw E 1-72 order
       Region 5ltw E 73-76 disorder
       Region 5ltw E 77-231 order
 Evidence X-RAY 5ltw B Reference
       Region 5ltw B 1-1 disorder
       Region 5ltw B 2-73 order
       Region 5ltw B 74-77 disorder
       Region 5ltw B 78-231 order
 Evidence X-RAY 5ltw A Reference
       Region 5ltw A 1-71 order
       Region 5ltw A 72-76 disorder
       Region 5ltw A 77-231 order
Seq 1-231 Hetero dimer : IID00304Complex
 Evidence X-RAY 3mhr A Reference
       Region 3mhr A 1-231 order
Seq 1-231 Hetero tetramer : Q9GZV5
 Evidence X-RAY 5n75 A Reference
       Region 5n75 A 1-71 order
       Region 5n75 A 72-73 disorder
       Region 5n75 A 74-231 order
 Evidence X-RAY 5n5w A Reference
       Region 5n5w A 1-70 order
       Region 5n5w A 71-77 disorder
       Region 5n5w A 78-231 order
 Evidence X-RAY 5n5t A Reference
       Region 5n5t A 1-71 order
       Region 5n5t A 72-77 disorder
       Region 5n5t A 78-136 order
       Region 5n5t A 137-138 disorder
       Region 5n5t A 139-231 order
Seq 1-231 Hetero tetramer : O14558
 Evidence X-RAY 5lu2 B Reference
       Region 5lu2 B 1-1 disorder
       Region 5lu2 B 2-72 order
       Region 5lu2 B 73-75 disorder
       Region 5lu2 B 76-231 order
 Evidence X-RAY 5lu2 A Reference
       Region 5lu2 A 1-1 disorder
       Region 5lu2 A 2-231 order
 Evidence X-RAY 5lu1 F Reference
       Region 5lu1 F 1-71 order
       Region 5lu1 F 72-75 disorder
       Region 5lu1 F 76-231 order
 Evidence X-RAY 5lu1 E Reference
       Region 5lu1 E 1-71 order
       Region 5lu1 E 72-77 disorder
       Region 5lu1 E 78-231 order
 Evidence X-RAY 5lu1 B Reference
       Region 5lu1 B 1-70 order
       Region 5lu1 B 71-77 disorder
       Region 5lu1 B 78-231 order
 Evidence X-RAY 5lu1 A Reference
       Region 5lu1 A 1-1 disorder
       Region 5lu1 A 2-71 order
       Region 5lu1 A 72-76 disorder
       Region 5lu1 A 77-231 order
Seq 1-231 Hetero tetramer : Q6TGC4
 Evidence X-RAY 4dau A Reference
       Region 4dau A 1-67 order
       Region 4dau A 68-77 disorder
       Region 4dau A 78-136 order
       Region 4dau A 137-139 disorder
       Region 4dau A 140-231 order
Seq 1-231 Hetero tetramer : Q8TF72
 Evidence X-RAY 6fcp A Reference
       Region 6fcp A 1-71 order
       Region 6fcp A 72-72 disorder
       Region 6fcp A 73-136 order
       Region 6fcp A 137-139 disorder
       Region 6fcp A 140-231 order
Seq 1-231 Hetero tetramer : IID00292Complex
 Evidence X-RAY 3o8i A Reference
       Region 3o8i A 1-67 order
       Region 3o8i A 68-77 disorder
       Region 3o8i A 78-136 order
       Region 3o8i A 137-139 disorder
       Region 3o8i A 140-208 order
       Region 3o8i A 209-211 disorder
       Region 3o8i A 212-231 order
 Evidence X-RAY 3iqv A Reference
       Region 3iqv A 1-231 order
 Evidence X-RAY 3iqu A Reference
       Region 3iqu A 1-231 order
 Evidence X-RAY 3iqj A Reference
       Region 3iqj A 1-231 order
Seq 1-248 Hetero tetramer :
 Evidence X-RAY 1ywt A Reference
       Region 1ywt A 1-70 order
       Region 1ywt A 71-78 disorder
       Region 1ywt A 79-231 order
       Region 1ywt A 232-248 disorder
 Evidence X-RAY 1ywt B Reference
       Region 1ywt B 1-69 order
       Region 1ywt B 70-78 disorder
       Region 1ywt B 79-231 order
       Region 1ywt B 232-248 disorder
Seq 1-248 Homo dimer :
 Evidence X-RAY 1yz5 B Reference
       Region 1yz5 B 1-1 disorder
       Region 1yz5 B 2-71 order
       Region 1yz5 B 72-73 disorder
       Region 1yz5 B 74-232 order
       Region 1yz5 B 233-248 disorder
 Evidence X-RAY 1yz5 A Reference
       Region 1yz5 A 1-70 order
       Region 1yz5 A 71-77 disorder
       Region 1yz5 A 78-209 order
       Region 1yz5 A 210-212 disorder
       Region 1yz5 A 213-233 order
       Region 1yz5 A 234-248 disorder
 Evidence X-RAY 3u9x A Reference
       Region 3u9x A 1-70 order
       Region 3u9x A 71-77 disorder
       Region 3u9x A 78-231 order
 Evidence X-RAY 3t0m A Reference
       Region 3t0m A 1-70 order
       Region 3t0m A 71-76 disorder
       Region 3t0m A 77-231 order
 Evidence X-RAY 3t0l A Reference
       Region 3t0l A 1-70 order
       Region 3t0l A 71-76 disorder
       Region 3t0l A 77-231 order
 Evidence X-RAY 5oma C Reference
       Region 5oma C 1-1 disorder
       Region 5oma C 2-72 order
       Region 5oma C 73-75 disorder
       Region 5oma C 76-231 order
 Evidence X-RAY 5oma A Reference
       Region 5oma A 1-74 order
       Region 5oma A 75-77 disorder
       Region 5oma A 78-231 order
 Evidence X-RAY 4dhu A Reference
       Region 4dhu A 1-70 order
       Region 4dhu A 71-77 disorder
       Region 4dhu A 78-231 order
 Evidence X-RAY 4dht A Reference
       Region 4dht A 1-70 order
       Region 4dht A 71-77 disorder
       Region 4dht A 78-231 order
 Evidence X-RAY 4dhs A Reference
       Region 4dhs A 1-70 order
       Region 4dhs A 71-77 disorder
       Region 4dhs A 78-231 order
 Evidence X-RAY 4dhr A Reference
       Region 4dhr A 1-70 order
       Region 4dhr A 71-77 disorder
       Region 4dhr A 78-231 order
 Evidence X-RAY 4dhq A Reference
       Region 4dhq A 1-70 order
       Region 4dhq A 71-74 disorder
       Region 4dhq A 75-231 order
 Evidence X-RAY 4dhp A Reference
       Region 4dhp A 1-70 order
       Region 4dhp A 71-77 disorder
       Region 4dhp A 78-231 order
 Evidence X-RAY 4dho A Reference
       Region 4dho A 1-70 order
       Region 4dho A 71-77 disorder
       Region 4dho A 78-231 order
 Evidence X-RAY 4dhn A Reference
       Region 4dhn A 1-70 order
       Region 4dhn A 71-77 disorder
       Region 4dhn A 78-231 order
 Evidence X-RAY 4dhm A Reference
       Region 4dhm A 1-70 order
       Region 4dhm A 71-77 disorder
       Region 4dhm A 78-231 order
Seq 1-248 Hetero tetramer : IID00015Complex
 Evidence X-RAY 3lw1 A Reference
       Region 3lw1 A 1-137 order
       Region 3lw1 A 138-138 disorder
       Region 3lw1 A 139-231 order
       Region 3lw1 A 232-248 disorder
Seqphosphorylation
    248-248 Phosphoserine
    74-74 Phosphoserine
    5-5 Phosphoserine
 
Prediction
NeProc
Disorder 235-248
Order 1-234
ProS 235-240
AlphaFold
Disorder 236-248
Order 1-235
Pfam Hmmer
PF00244 3-238 3e-142
SEG 235-247
Function
Function in SwissProt
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.
p53-regulated inhibitor of G2/M progression.
Biological Process
See also
Diagram with PDB data
ESR1/SFN14-3-3 protein interaction with Estrogen Receptor Alpha provides a novel drug target interface
RAF1/YWHAZHuman 14-3-3 isoform zeta in complex with a diphoyphorylated C-RAF peptide and Cotylenin A
TP53/SFNCrystal structure of 14-3-3sigma and a p53 C-terminal 12-mer synthetic phosphopeptide
YAP1/SFN14-3-3 sigma in complex with YAP pS127-peptide
FOXO1/SFN14-3-3 sigma in complex with FOXO1 pT24 peptide
GAB2/GRB2Grb2 SH3C (3)
Diagram without PDB data
CDKN1BActivation of Akt results in phosphorylation p27, which are then transported to the cytoplasm with 14-3-3.
FOXO4Stress signals in FOXO regulation