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IID00311
 UniprotP62136
ProteinSerine/threonine-protein phosphatase PP1-alpha catalytic subunit
GenePPP1CA
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
330
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-300 Hetero trimer : IID00017Complex
 Evidence X-RAY 3n5u B Reference
       Region 3n5u B 1-6 disorder
       Region 3n5u B 7-300 order
 Evidence X-RAY 3n5u A Reference
       Region 3n5u A 1-6 disorder
       Region 3n5u A 7-300 order
Seq 1-330 Hetero dimer :
 Evidence X-RAY 4g9j B Reference
       Region 4g9j B 1-6 disorder
       Region 4g9j B 7-300 order
       Region 4g9j B 301-330 disorder
Seq 1-330 Hetero dimer :
 Evidence X-RAY 4g9j A Reference
       Region 4g9j A 1-8 disorder
       Region 4g9j A 9-300 order
       Region 4g9j A 301-330 disorder
Seq 7-300 Hetero dimer : Q69YH5
 Evidence X-RAY 5ioh C Reference
       Region 5ioh C 7-300 order
 Evidence X-RAY 5ioh A Reference
       Region 5ioh A 7-299 order
       Region 5ioh A 300-300 disorder
Seq 7-300 Hetero dimer : O75807
 Evidence X-RAY 4xpn C Reference
       Region 4xpn C 7-299 order
       Region 4xpn C 300-300 disorder
 Evidence X-RAY 4xpn A Reference
       Region 4xpn A 7-299 order
       Region 4xpn A 300-300 disorder
Seq 7-300 Monomer :
 Evidence X-RAY 4mov B Reference
       Region 4mov B 7-22 order
       Region 4mov B 23-24 disorder
       Region 4mov B 25-299 order
       Region 4mov B 300-300 disorder
 Evidence X-RAY 4mov A Reference
       Region 4mov A 7-299 order
       Region 4mov A 300-300 disorder
 Evidence X-RAY 3e7b B Reference
       Region 3e7b B 7-299 order
       Region 3e7b B 300-300 disorder
 Evidence X-RAY 3e7b A Reference
       Region 3e7b A 7-299 order
       Region 3e7b A 300-300 disorder
 Evidence X-RAY 3e7a B Reference
       Region 3e7a B 7-299 order
       Region 3e7a B 300-300 disorder
 Evidence X-RAY 3e7a A Reference
       Region 3e7a A 7-299 order
       Region 3e7a A 300-300 disorder
 Evidence X-RAY 6alz B Reference
       Region 6alz B 7-299 order
       Region 6alz B 300-300 disorder
 Evidence X-RAY 6alz A Reference
       Region 6alz A 7-299 order
       Region 6alz A 300-300 disorder
Seq 7-300 Hetero dimer : IID50266Complex
 Evidence X-RAY 4mp0 C Reference
       Region 4mp0 C 7-297 order
       Region 4mp0 C 298-300 disorder
 Evidence X-RAY 4mp0 A Reference
       Region 4mp0 A 7-300 order
 Evidence X-RAY 4moy A Reference
       Region 4moy A 7-300 order
Seq 7-307 Hetero dimer : IID00666Complex
 Evidence X-RAY 3v4y G Reference
       Region 3v4y G 7-298 order
       Region 3v4y G 299-307 disorder
 Evidence X-RAY 3v4y E Reference
       Region 3v4y E 7-299 order
       Region 3v4y E 300-307 disorder
 Evidence X-RAY 3v4y C Reference
       Region 3v4y C 7-300 order
       Region 3v4y C 301-307 disorder
 Evidence X-RAY 3v4y A Reference
       Region 3v4y A 7-299 order
       Region 3v4y A 300-307 disorder
Seq 7-330 Hetero trimer : IID50060Complex
 Evidence X-RAY 3hvq B Reference
       Region 3hvq B 7-300 order
       Region 3hvq B 301-330 disorder
 Evidence X-RAY 3hvq A Reference
       Region 3hvq A 7-300 order
       Region 3hvq A 301-330 disorder
Seq 7-330 Hetero dimer : IID50058Complex
 Evidence X-RAY 3egh A Reference
       Region 3egh A 7-300 order
       Region 3egh A 301-330 disorder
 Evidence X-RAY 3egg A Reference
       Region 3egg A 7-300 order
       Region 3egg A 301-330 disorder
Seq 7-330 Hetero trimer : IID50058Complex
 Evidence X-RAY 3egh B Reference
       Region 3egh B 7-300 order
       Region 3egh B 301-330 disorder
 Evidence X-RAY 3egh A Reference
       Region 3egh A 7-300 order
       Region 3egh A 301-330 disorder
Seq 7-330 Hetero dimer : IID50058Complex
 Evidence X-RAY 3egh B Reference
       Region 3egh B 7-300 order
       Region 3egh B 301-330 disorder
 Evidence X-RAY 3egg B Reference
       Region 3egg B 7-300 order
       Region 3egg B 301-330 disorder
Seqphosphorylation
    2-2 Phosphoserine
    22-22 Phosphoserine
    306-306 Phosphotyrosine
    320-320 Phosphothreonine
    325-325 Phosphoserine
Seqacetylation
    2-2 N-acetylserine
    305-305 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-5,304-330
Order 6-303
ProS 304-310
AlphaFold
Disorder 1-5,300-330
Order 6-299
Pfam Hmmer
PF00149 57-252 2.6e-44
Function
Function in SwissProt
Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Dephosphorylates CENPA (PubMed:25556658). Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy (PubMed:26083323).
(Microbial infection) Necessary for alphaviruses replication.
Biological Process
See also
Diagram with PDB data
AXIN1/GSK3BCrystal structure of GSK-3/Axin complex bound to phosphorylated N-terminal auto-inhibitory pS9 peptide
RAF1/YWHAZHuman 14-3-3 isoform zeta in complex with a diphoyphorylated C-RAF peptide and Cotylenin A
RB1/PPP1CACrystal structure of an Rb C-terminal peptide bound to the catalytic subunit of PP1