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IID00327
 UniprotQ96T88
ProteinE3 ubiquitin-protein ligase UHRF1
GeneUHRF1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
793
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-76 Monomer :
 Evidence X-RAY 2faz A Reference
       Region 2faz A 1-76 order
 Evidence X-RAY 2faz B Reference
       Region 2faz B 1-72 order
       Region 2faz B 73-76 disorder
Seq 126-285 Hetero dimer : IID00088Complex
 Evidence X-RAY 3db3 A Reference
       Region 3db3 A 126-126 disorder
       Region 3db3 A 127-162 order
       Region 3db3 A 163-179 disorder
       Region 3db3 A 180-283 order
       Region 3db3 A 284-285 disorder
Seq 126-285 Monomer :
 Evidence X-RAY 3db4 A Reference
       Region 3db4 A 126-128 disorder
       Region 3db4 A 129-132 order
       Region 3db4 A 133-133 disorder
       Region 3db4 A 134-161 order
       Region 3db4 A 162-179 disorder
       Region 3db4 A 180-261 order
       Region 3db4 A 262-262 disorder
       Region 3db4 A 263-283 order
       Region 3db4 A 284-285 disorder
Seq 126-285 Hetero dimer : Q3BDD9
 Evidence NMR 2l3r A Reference
       Region 2l3r A 126-285 order
       Region 2l3r A 168-174 high_rmsd
Seq 126-285 Homo dimer :
 Evidence X-RAY 4qqd A Reference
       Region 4qqd A 126-132 disorder
       Region 4qqd A 133-162 order
       Region 4qqd A 163-178 disorder
       Region 4qqd A 179-282 order
       Region 4qqd A 283-285 disorder
 Evidence X-RAY 4qqd B Reference
       Region 4qqd B 126-127 order
       Region 4qqd B 128-132 disorder
       Region 4qqd B 133-162 order
       Region 4qqd B 163-177 disorder
       Region 4qqd B 178-281 order
       Region 4qqd B 282-285 disorder
Seq 134-367 Hetero hexamer : IID00239Complex
 Evidence X-RAY 3ask A Reference
       Region 3ask A 134-163 order
       Region 3ask A 164-164 disorder
       Region 3ask A 174-178 disorder
       Region 3ask A 179-325 order
       Region 3ask A 326-327 disorder
       Region 3ask A 328-344 order
       Region 3ask A 345-346 disorder
       Region 3ask A 347-364 order
       Region 3ask A 365-367 disorder
 Evidence X-RAY 3ask B Reference
       Region 3ask B 134-162 order
       Region 3ask B 163-164 disorder
       Region 3ask B 174-179 disorder
       Region 3ask B 180-344 order
       Region 3ask B 345-347 disorder
       Region 3ask B 348-363 order
       Region 3ask B 364-367 disorder
 Evidence X-RAY 3ask C Reference
       Region 3ask C 134-162 order
       Region 3ask C 163-164 disorder
       Region 3ask C 174-178 disorder
       Region 3ask C 179-302 order
       Region 3ask C 303-367 disorder
 Evidence X-RAY 3ask D Reference
       Region 3ask D 134-161 order
       Region 3ask D 162-164 disorder
       Region 3ask D 174-178 disorder
       Region 3ask D 179-301 order
       Region 3ask D 302-367 disorder
 Evidence X-RAY 4gy5 A Reference
       Region 4gy5 A 134-162 order
       Region 4gy5 A 163-179 disorder
       Region 4gy5 A 180-364 order
       Region 4gy5 A 365-366 disorder
 Evidence X-RAY 4gy5 B Reference
       Region 4gy5 B 134-162 order
       Region 4gy5 B 163-179 disorder
       Region 4gy5 B 180-344 order
       Region 4gy5 B 345-347 disorder
       Region 4gy5 B 348-363 order
       Region 4gy5 B 364-366 disorder
 Evidence X-RAY 4gy5 C Reference
       Region 4gy5 C 134-162 order
       Region 4gy5 C 163-177 disorder
       Region 4gy5 C 178-302 order
       Region 4gy5 C 303-366 disorder
 Evidence X-RAY 4gy5 D Reference
       Region 4gy5 D 134-161 order
       Region 4gy5 D 162-179 disorder
       Region 4gy5 D 180-301 order
       Region 4gy5 D 302-366 disorder
Seq 134-285,642-657 Hetero dimer :
 Evidence NMR 5iay A Reference
       Region 5iay A 134-285 order
       Region 5iay A 167-174 high_rmsd
 Evidence NMR 5iay B Reference
       Region 5iay B 642-657 order
Seq 296-367 Hetero tetramer : IID00062Complex
 Evidence X-RAY 3zvy A Reference
       Region 3zvy A 296-299 disorder
       Region 3zvy A 300-364 order
       Region 3zvy A 365-367 disorder
 Evidence X-RAY 3zvy B Reference
       Region 3zvy B 296-299 disorder
       Region 3zvy B 300-365 order
       Region 3zvy B 366-367 disorder
Seq 298-366 Hetero dimer :
 Evidence NMR 2lgg A Reference
       Region 2lgg A 298-366 order
       Region 2lgg A 298-303 high_rmsd
       Region 2lgg A 366-366 high_rmsd
Seq 298-366 Hetero dimer :
 Evidence X-RAY 3shb A Reference
       Region 3shb A 298-364 order
       Region 3shb A 365-366 disorder
Seq 298-366 Hetero dimer :
 Evidence NMR 2lgk A Reference
       Region 2lgk A 298-366 order
       Region 2lgk A 298-299 high_rmsd
Seq 298-367 Hetero dimer : IID00239Complex
 Evidence X-RAY 3asl A Reference
       Region 3asl A 298-298 disorder
       Region 3asl A 299-366 order
       Region 3asl A 367-367 disorder
Seq 298-367 Hetero dimer : IID00062Complex
 Evidence X-RAY 3sou A Reference
       Region 3sou A 298-299 disorder
       Region 3sou A 300-367 order
 Evidence X-RAY 3sou B Reference
       Region 3sou B 298-298 disorder
       Region 3sou B 299-367 order
 Evidence X-RAY 3sow A Reference
       Region 3sow A 298-299 disorder
       Region 3sow A 300-366 order
       Region 3sow A 367-367 disorder
 Evidence X-RAY 3sow B Reference
       Region 3sow B 298-299 disorder
       Region 3sow B 300-364 order
       Region 3sow B 365-367 disorder
Seq 298-367 Monomer :
 Evidence NMR 2lgl A Reference
       Region 2lgl A 298-366 order
       Region 2lgl A 298-311 high_rmsd
 Evidence X-RAY 3sox A Reference
       Region 3sox A 298-298 disorder
       Region 3sox A 299-363 order
       Region 3sox A 364-367 disorder
 Evidence X-RAY 3sox B Reference
       Region 3sox B 298-298 disorder
       Region 3sox B 299-363 order
       Region 3sox B 364-367 disorder
 Evidence X-RAY 3zvz B Reference
       Region 3zvz B 314-365 order
       Region 3zvz B 366-367 disorder
Seq 299-364 Hetero trimer : IID00086Complex
 Evidence X-RAY 3t6r A Reference
       Region 3t6r A 299-364 order
 Evidence X-RAY 3t6r B Reference
       Region 3t6r B 299-364 order
Seq 408-643 Monomer :
 Evidence X-RAY 2pb7 A Reference
       Region 2pb7 A 408-408 disorder
       Region 2pb7 A 409-483 order
       Region 2pb7 A 484-493 disorder
       Region 2pb7 A 494-615 order
       Region 2pb7 A 616-643 disorder
 Evidence X-RAY 3bi7 A Reference
       Region 3bi7 A 414-483 order
       Region 3bi7 A 484-495 disorder
       Region 3bi7 A 496-617 order
 Evidence X-RAY 3clz A Reference
       Region 3clz A 414-415 disorder
       Region 3clz A 416-617 order
 Evidence X-RAY 3clz B Reference
       Region 3clz B 414-414 disorder
       Region 3clz B 415-617 order
 Evidence X-RAY 3clz C Reference
       Region 3clz C 414-415 disorder
       Region 3clz C 416-617 order
 Evidence X-RAY 3clz D Reference
       Region 3clz D 414-415 disorder
       Region 3clz D 416-617 order
 Evidence X-RAY 3dwh A Reference
       Region 3dwh A 414-483 order
       Region 3dwh A 484-495 disorder
       Region 3dwh A 496-614 order
       Region 3dwh A 615-617 disorder
Seq 634-665 Hetero dimer : IID00176Complex
 Evidence X-RAY 5c6d C Reference
       Region 5c6d C 634-638 disorder
       Region 5c6d C 639-651 order
       Region 5c6d C 652-665 disorder
 Evidence X-RAY 5c6d D Reference
       Region 5c6d D 634-642 disorder
       Region 5c6d D 643-649 order
       Region 5c6d D 650-665 disorder
Seq 638-678 Hetero tetramer : E7EZF3
 Evidence X-RAY 6b9m D Reference
       Region 6b9m D 638-647 disorder
       Region 6b9m D 648-664 order
       Region 6b9m D 665-678 disorder
Seq 672-793 Monomer :
 Evidence X-RAY 3fl2 A Reference
       Region 3fl2 A 672-674 disorder
       Region 3fl2 A 675-700 order
       Region 3fl2 A 701-703 disorder
       Region 3fl2 A 704-793 order
SeqProS possible 639-651 This region is described to be disordered in the free state. (PubMed=25891992) Hetero dimer : IID00176Complex
       Region 5c6d C 639-651 order
       Region 5c6d D 643-649 order
Seqphosphorylation
    76-76 Phosphoserine
    91-91 Phosphoserine
    95-95 Phosphoserine
    165-165 Phosphoserine
    287-287 Phosphoserine
    298-298 Phosphoserine; by PKA
    368-368 Phosphoserine
    639-639 Phosphoserine; by CDK1
    651-651 Phosphoserine
    707-707 Phosphoserine
    709-709 Phosphoserine
Seqacetylation
    399-399 N6-acetyllysine
    546-546 N6-acetyllysine; alternate
 
Prediction
NeProc
Disorder 78-125,164-177,288-291,374-398,491-494,614-672
Order 1-77,126-163,178-287,292-373,399-490,495-613,673-793
ProS 94-96,374-379,389-398,491-494,614-619,625-629,634-639,644-649
AlphaFold
Disorder 75-129,131-131,162-180,365-399,403-403,629-629,631-673,704-708,792-792
Order 1-74,130-130,132-161,181-364,400-402,404-628,630-630,674-703,709-791,793-793
Pfam Hmmer
PF00240 6-76 4.5e-17
PF00628 317-366 2.9e-15
PF02182 414-586 7.5e-43
SEG 380-393 ,617-634 ,651-664
Function
Function in SwissProt
Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications. Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins such as histone H3 and PML. It is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo. May be involved in DNA repair.
Biological Process
Diagram with PDB data
UHRF1/USP7Crystal structure of USP7 in complex with UHRF1
UHRF1Crystal structure of UHRF1 TTD domain in complex with the polybasic region