Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4.
Isoform 2
Not functional in the nucleotide excision repair pathway.
Isoform 3
Not functional in the nucleotide excision repair pathway.
Isoform 4
Not functional in the nucleotide excision repair pathway.
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