Search Keyword:


Search option:


IID00437
 UniprotP05412
ProteinTranscription factor AP-1
GeneJUN
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
331
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 253-308 Hetero trimer : IID00436Complex,IID00470Complex
 Evidence X-RAY 1s9k E Reference
       Region 1s9k E 257-308 order
 Evidence X-RAY 1a02 J Reference
       Region 1a02 J 253-256 disorder
       Region 1a02 J 257-308 order
Seq 254-314 Hetero tetramer : IID00441Complex
 Evidence X-RAY 1t2k C Reference
       Region 1t2k C 254-314 order
Seq 254-315 Hetero dimer : IID00436Complex
 Evidence X-RAY 1fos H Reference
       Region 1fos H 254-255 disorder
       Region 1fos H 256-313 order
       Region 1fos H 314-315 disorder
 Evidence X-RAY 1fos F Reference
       Region 1fos F 254-256 disorder
       Region 1fos F 257-313 order
       Region 1fos F 314-315 disorder
Seq 254-315 Homo dimer :
 Evidence X-RAY 5t01 B Reference
       Region 5t01 B 254-313 order
       Region 5t01 B 314-315 disorder
 Evidence X-RAY 5t01 A Reference
       Region 5t01 A 254-313 order
       Region 5t01 A 314-315 disorder
 Evidence X-RAY 1jnm B Reference
       Region 1jnm B 254-310 order
       Region 1jnm B 311-315 disorder
 Evidence X-RAY 1jnm A Reference
       Region 1jnm A 254-309 order
       Region 1jnm A 310-315 disorder
Seq 276-314 Homo dimer :
 Evidence NMR 1jun B Reference
       Region 1jun B 276-314 order
       Region 1jun B 314-314 high_rmsd
 Evidence NMR 1jun A Reference
       Region 1jun A 276-314 order
       Region 1jun A 314-314 high_rmsd
Seq 277-308 Hetero tetramer :
 Evidence X-RAY 5fv8 D Reference
       Region 5fv8 D 277-306 order
       Region 5fv8 D 307-308 disorder
 Evidence X-RAY 5fv8 E Reference
       Region 5fv8 E 277-308 order
Seqphosphorylation
    249-249 Phosphoserine; by GSK3-beta
    243-243 Phosphoserine; by DYRK2 and GSK3-beta
    239-239 Phosphothreonine; by GSK3-beta
    93-93 Phosphothreonine; by PAK2
    91-91 Phosphothreonine
    89-89 Phosphothreonine; by PAK2
    73-73 Phosphoserine; by MAPK8 and PLK3
    63-63 Phosphoserine; by MAPK8 and PLK3
    58-58 Phosphoserine
    8-8 Phosphothreonine; by PAK2
    2-2 Phosphothreonine; by PAK2
    286-286 Phosphothreonine; by PAK2
Seqacetylation
    271-271 N6-acetyllysine
    56-56 N6-acetyllysine; alternate
 
Prediction
NeProc
Disorder 1-249,328-331
Order 250-327
ProS 1-13,24-44,58-63,74-79,106-148,171-177,196-198,231-237,248-249,328-331
AlphaFold
Disorder 1-73,75-77,79-79,82-103,107-108,125-245,322-331
Order 74-74,78-78,80-81,104-106,109-124,246-321
Pfam Hmmer
PF03957 5-241 1.6e-131
PF00170 250-314 1.9e-22
SEG 139-162 ,178-196 ,198-220
Function
Function in SwissProt
Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3' (PubMed:10995748, PubMed:22083952). Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (PubMed:17210646). Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306).
Biological Process
See also
Diagram with PDB data
NFATC2/FOS/JUN/DNASTRUCTURE OF THE DNA BINDING DOMAINS OF NFAT, FOS AND JUN BOUND TO DNA