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IID00540
 UniprotP13569
ProteinCystic fibrosis transmembrane conductance regulator
GeneCFTR
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1480
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 5-20 Hetero trimer : P21333
 Evidence X-RAY 3isw C Reference
       Region 3isw C 5-20 order
Seq 375-678 Monomer :
 Evidence X-RAY 1xmj A Reference
       Region 1xmj A 389-390 disorder
       Region 1xmj A 391-402 order
       Region 1xmj A 403-437 disorder
       Region 1xmj A 438-507 order
       Region 1xmj A 509-645 order
       Region 1xmj A 646-648 disorder
       Region 1xmj A 649-675 order
       Region 1xmj A 676-677 disorder
 Evidence X-RAY 4wz6 A Reference
       Region 4wz6 A 389-414 order
       Region 4wz6 A 415-433 disorder
       Region 4wz6 A 434-507 order
       Region 4wz6 A 509-541 order
       Region 4wz6 A 542-544 disorder
       Region 4wz6 A 545-645 order
       Region 4wz6 A 646-648 disorder
       Region 4wz6 A 649-672 order
       Region 4wz6 A 673-678 disorder
 Evidence X-RAY 2pzg B Reference
       Region 2pzg B 375-386 disorder
       Region 2pzg B 387-404 order
       Region 2pzg B 437-542 order
       Region 2pzg B 543-545 disorder
       Region 2pzg B 546-636 order
       Region 2pzg B 637-646 disorder
 Evidence X-RAY 2pzg A Reference
       Region 2pzg A 375-389 disorder
       Region 2pzg A 390-404 order
       Region 2pzg A 437-635 order
       Region 2pzg A 636-637 disorder
       Region 2pzg A 638-646 order
 Evidence X-RAY 2pzf B Reference
       Region 2pzf B 387-387 disorder
       Region 2pzf B 388-404 order
       Region 2pzf B 437-507 order
       Region 2pzf B 509-636 order
       Region 2pzf B 637-646 disorder
 Evidence X-RAY 2pzf A Reference
       Region 2pzf A 387-401 order
       Region 2pzf A 402-403 disorder
       Region 2pzf A 404-404 order
       Region 2pzf A 437-507 order
       Region 2pzf A 509-636 order
       Region 2pzf A 637-638 disorder
       Region 2pzf A 639-646 order
 Evidence X-RAY 2pze B Reference
       Region 2pze B 387-388 disorder
       Region 2pze B 389-404 order
       Region 2pze B 437-639 order
       Region 2pze B 640-646 disorder
 Evidence X-RAY 2pze A Reference
       Region 2pze A 387-404 order
       Region 2pze A 437-636 order
       Region 2pze A 637-638 disorder
       Region 2pze A 639-645 order
       Region 2pze A 646-646 disorder
 Evidence X-RAY 2bbt B Reference
       Region 2bbt B 389-418 order
       Region 2bbt B 419-437 disorder
       Region 2bbt B 438-507 order
       Region 2bbt B 509-541 order
       Region 2bbt B 542-544 disorder
       Region 2bbt B 545-645 order
       Region 2bbt B 646-647 disorder
       Region 2bbt B 648-671 order
       Region 2bbt B 672-678 disorder
 Evidence X-RAY 2bbt A Reference
       Region 2bbt A 389-389 disorder
       Region 2bbt A 390-413 order
       Region 2bbt A 414-436 disorder
       Region 2bbt A 437-507 order
       Region 2bbt A 509-542 order
       Region 2bbt A 543-544 disorder
       Region 2bbt A 545-642 order
       Region 2bbt A 643-647 disorder
       Region 2bbt A 648-669 order
       Region 2bbt A 670-678 disorder
 Evidence X-RAY 2bbs B Reference
       Region 2bbs B 389-401 order
       Region 2bbs B 402-439 disorder
       Region 2bbs B 440-507 order
       Region 2bbs B 509-542 order
       Region 2bbs B 543-544 disorder
       Region 2bbs B 545-637 order
       Region 2bbs B 638-647 disorder
       Region 2bbs B 648-670 order
       Region 2bbs B 671-677 disorder
 Evidence X-RAY 2bbs A Reference
       Region 2bbs A 389-413 order
       Region 2bbs A 414-436 disorder
       Region 2bbs A 437-507 order
       Region 2bbs A 509-541 order
       Region 2bbs A 542-545 disorder
       Region 2bbs A 546-645 order
       Region 2bbs A 646-648 disorder
       Region 2bbs A 649-671 order
       Region 2bbs A 672-677 disorder
 Evidence X-RAY 2bbo A Reference
       Region 2bbo A 389-404 order
       Region 2bbo A 405-435 disorder
       Region 2bbo A 436-645 order
       Region 2bbo A 646-648 disorder
       Region 2bbo A 649-676 order
       Region 2bbo A 677-678 disorder
Seq 389-678 Homo pentamer :
 Evidence X-RAY 1xmi E Reference
       Region 1xmi E 389-411 order
       Region 1xmi E 412-428 disorder
       Region 1xmi E 429-671 order
       Region 1xmi E 672-678 disorder
 Evidence X-RAY 1xmi D Reference
       Region 1xmi D 389-410 order
       Region 1xmi D 411-425 disorder
       Region 1xmi D 426-543 order
       Region 1xmi D 544-545 disorder
       Region 1xmi D 546-672 order
       Region 1xmi D 673-678 disorder
 Evidence X-RAY 1xmi C Reference
       Region 1xmi C 389-415 order
       Region 1xmi C 416-428 disorder
       Region 1xmi C 429-671 order
       Region 1xmi C 672-678 disorder
 Evidence X-RAY 1xmi B Reference
       Region 1xmi B 389-413 order
       Region 1xmi B 414-428 disorder
       Region 1xmi B 429-532 order
       Region 1xmi B 533-538 disorder
       Region 1xmi B 539-541 order
       Region 1xmi B 542-546 disorder
       Region 1xmi B 547-671 order
       Region 1xmi B 672-678 disorder
 Evidence X-RAY 1xmi A Reference
       Region 1xmi A 389-411 order
       Region 1xmi A 412-428 disorder
       Region 1xmi A 429-671 order
       Region 1xmi A 672-678 disorder
Seq 747-774 Hetero trimer : IID00061Complex
 Evidence X-RAY 5d3f C Reference
       Region 5d3f C 747-749 disorder
       Region 5d3f C 750-756 order
       Region 5d3f C 757-763 disorder
       Region 5d3f C 764-774 order
 Evidence X-RAY 5d2d C Reference
       Region 5d2d C 747-750 disorder
       Region 5d2d C 751-758 order
       Region 5d2d C 759-763 disorder
       Region 5d2d C 764-774 order
Seq 762-801 Hetero trimer : P61981
 Evidence X-RAY 5d3e K Reference
       Region 5d3e K 762-766 disorder
       Region 5d3e K 767-770 order
       Region 5d3e K 771-801 disorder
Seq 762-801 Hetero trimer : P61981
 Evidence X-RAY 5d3e G Reference
       Region 5d3e G 762-766 disorder
       Region 5d3e G 767-771 order
       Region 5d3e G 772-792 disorder
       Region 5d3e G 793-798 order
       Region 5d3e G 799-801 disorder
 Evidence X-RAY 5d3e C Reference
       Region 5d3e C 762-765 disorder
       Region 5d3e C 766-770 order
       Region 5d3e C 771-792 disorder
       Region 5d3e C 793-798 order
       Region 5d3e C 799-801 disorder
Seq 1193-1427 Monomer : P68187
 Evidence X-RAY 3gd7 B Reference
       Region 3gd7 B 1193-1202 disorder
       Region 3gd7 B 1203-1427 order
Seq 1193-1427 Monomer : P68187
 Evidence X-RAY 3gd7 A Reference
       Region 3gd7 A 1193-1201 disorder
       Region 3gd7 A 1202-1427 order
Seq 1193-1427 Monomer : P68187
 Evidence X-RAY 3gd7 D Reference
       Region 3gd7 D 1193-1201 disorder
       Region 3gd7 D 1202-1427 order
Seq 1193-1427 Monomer : P68187
 Evidence X-RAY 3gd7 C Reference
       Region 3gd7 C 1193-1203 disorder
       Region 3gd7 C 1204-1427 order
Seq 1473-1480 Hetero dimer : IID00520Complex
 Evidence NMR 2lob B Reference
       Region 2lob B 1473-1480 order
SeqProS predicted 751-758,764-774 The unbound state of this region is predicted to be disordered by DICHOT, FoldIndex and MobiDB Hetero trimer : IID00061Complex
       Region 5d3f C 750-756 order
       Region 5d2d C 751-758 order
       Region 5d3f C 764-774 order
       Region 5d2d C 764-774 order
SeqProS predicted 766-770 The unbound state of this region is predicted to be disordered by DICHOT, FoldIndex and MobiDB Hetero trimer : P61981
       Region 5d3e K 767-770 order
SeqProS predicted 766-770,793-798 The unbound state of this region is predicted to be disordered by DICHOT, FoldIndex and MobiDB Hetero trimer : P61981
       Region 5d3e C 766-770 order
       Region 5d3e G 767-771 order
       Region 5d3e C 793-798 order
       Region 5d3e G 793-798 order
Seqphosphorylation
    1456-1456 Phosphoserine
    795-795 Phosphoserine; by PKA
    813-813 Phosphoserine; by PKA
    1444-1444 Phosphoserine
    753-753 Phosphoserine; by PKA
    768-768 Phosphoserine; by PKA
    790-790 Phosphoserine; by PKC
    737-737 Phosphoserine; by PKA
    717-717 Phosphothreonine
    700-700 Phosphoserine; by PKA
    712-712 Phosphoserine; by PKA
    549-549 Phosphoserine
    660-660 Phosphoserine; by PKA
    670-670 Phosphoserine; by PKA
    686-686 Phosphoserine; by PKC
 
Prediction
NeProc
Disorder 1-4,242-249,405-421,646-736,776-846,1176-1192,1445-1480
Order 5-241,250-383,391-404,422-645,737-775,847-1175,1193-1444
ProS 1-4,242-249,405-421,663-673,696-716,724-736,776-784,840-846,1176-1184,1476-1480
AlphaFold
Disorder 1-1,178-178,186-189,383-390,403-406,408-437,460-461,485-486,543-543,637-661,663-664,667-843,887-912,969-970,1124-1125,1173-1202,1373-1380,1403-1403,1434-1480
Order 2-177,179-185,190-382,391-402,407-407,438-459,462-484,487-542,544-636,662-662,665-666,844-886,913-968,971-1123,1126-1172,1203-1372,1381-1402,1404-1433
Pfam Hmmer
PF00664 81-350 3.5e-56
PF00005 451-622 3.4e-54
PF00664 862-1147 3e-62
PF00005 1237-1419 8.5e-60
SEG 305-322 ,995-1012 ,1106-1119
Function
Function in SwissProt
Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis (PubMed:26823428). Mediates the transport of chloride ions across the cell membrane (PubMed:10792060, PubMed:11524016, PubMed:11707463, PubMed:12519745, PubMed:15010471, PubMed:12588899, PubMed:17036051, PubMed:19398555, PubMed:19621064, PubMed:22178883, PubMed:25330774, PubMed:1712898, PubMed:8910473, PubMed:9804160, PubMed:12529365, PubMed:17182731, PubMed:26846474, PubMed:28087700). Channel activity is coupled to ATP hydrolysis (PubMed:8910473). The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration (PubMed:15010471, PubMed:19019741). Exerts its function also by modulating the activity of other ion channels and transporters (PubMed:12403779, PubMed:22178883, PubMed:22121115, PubMed:27941075). Plays an important role in airway fluid homeostasis (PubMed:16645176, PubMed:19621064, PubMed:26823428). Contributes to the regulation of the pH and the ion content of the airway surface fluid layer and thereby plays an important role in defense against pathogens (PubMed:14668433, PubMed:16645176, PubMed:26823428). Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex (PubMed:17434346, PubMed:27941075, PubMed:17182731). Inhibits the activity of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G (PubMed:17182731). Inhibits the activity of the ENaC channel containing subunits SCNN1D, SCNN1B and SCNN1G, but not of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G (PubMed:27941075). May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7 (PubMed:12403779). Can inhibit the chloride channel activity of ANO1 (PubMed:22178883). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (PubMed:19923167, PubMed:27714810).
Biological Process
Diagram with PDB data
CFTR/YWHAZCrystal structure of human 14-3-3 zeta in complex with CFTR R-domain peptide pS753-pS768
CFTR/GOPCPDZ Domain of CAL (Cystic Fibrosis Transmembrane Regulator-Associated Ligand)