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IID00549
UniprotP32780
ProteinGeneral transcription factor IIH subunit 1
GeneGTF2H1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
548
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-108 Hetero dimer : IID00164Complex
 Evidence NMR 2rvb B Reference
       Region 2rvb B 1-108 order
       Region 2rvb B 1-3 high_rmsd
       Region 2rvb B 107-108 high_rmsd
Seq 1-108 Hetero dimer : IID00548Complex
 Evidence NMR 2rnr B Reference
       Region 2rnr B 1-108 order
       Region 2rnr B 1-4 high_rmsd
       Region 2rnr B 106-108 high_rmsd
Seq 1-108 Monomer :
 Evidence NMR 1pfj A Reference
       Region 1pfj A 1-108 order
       Region 1pfj A 1-3 high_rmsd
       Region 1pfj A 107-108 high_rmsd
Seq 1-108 Hetero dimer : IID00015Complex
 Evidence NMR 2ruk B Reference
       Region 2ruk B 1-108 order
       Region 2ruk B 1-4 high_rmsd
       Region 2ruk B 106-108 high_rmsd
Seq 1-108 Hetero dimer : IID00076Complex
 Evidence NMR 5gow B Reference
       Region 5gow B 1-108 order
       Region 5gow B 1-5 high_rmsd
       Region 5gow B 106-108 high_rmsd
Seq 2-108 Hetero dimer : Q2YD98
 Evidence NMR 5xv8 B Reference
       Region 5xv8 B 2-108 order
       Region 5xv8 B 2-3 high_rmsd
       Region 5xv8 B 106-108 high_rmsd
Seq 103-150 Monomer :
 Evidence NMR 2dii A Reference
       Region 2dii A 103-150 order
       Region 2dii A 103-105 high_rmsd
       Region 2dii A 149-150 high_rmsd
Seqphosphorylation
    357-357 Phosphoserine
    339-339 Phosphoserine
Seqacetylation
    240-240 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-6,155-172,279-296,303-314,320-346,379-398,415-425,433-453,542-548
Order 7-36,42-56,62-154,173-278,297-302,315-319,347-378,399-414,426-432,454-541
ProS 158-168,279-296,303-314,341-346,379-387,392-398,415-425,433-445
AlphaFold
Disorder 1-6,103-108,147-165,172-185,228-228,231-241,259-295,320-347,443-452,516-519,548-548
Order 7-102,109-146,166-171,186-227,229-230,242-258,296-319,348-442,453-515,520-547
Pfam Hmmer
PF08567 9-81 1.1e-32
PF03909 94-160 5.8e-14
PF03909 173-238 8.7e-19
SEG 418-435
Function
Function in SwissProt
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
Biological Process
See also
Diagram with PDB data
TP53/GTF2H1Solution structure of the complex between p53 transactivation domain 2 and TFIIH p62 PH domain
XPA/ERCC1Solution structure of a ERCC1-XPA heterodimer
XPC/GTF2H1Solution structure of the complex between XPC acidic domain and TFIIH p62 PH domain
TFDP1/GTF2H1Solution structure of the complex between DP1 acidic region and TFIIH p62 PH domain