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IID00615
 UniprotP13612
ProteinIntegrin alpha-4
GeneITGA4
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1032
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 34-620 Hetero tetramer : IID00616Complex
 Evidence X-RAY 3v4v C Reference
       Region 3v4v C 34-586 order
       Region 3v4v C 587-593 disorder
       Region 3v4v C 594-620 order
Seq 34-620 Hetero tetramer : IID00616Complex
 Evidence X-RAY 3v4v A Reference
       Region 3v4v A 34-586 order
       Region 3v4v A 587-591 disorder
       Region 3v4v A 592-620 order
Seq 34-620 Hetero tetramer : IID00616Complex
 Evidence X-RAY 3v4p C Reference
       Region 3v4p C 34-586 order
       Region 3v4p C 587-592 disorder
       Region 3v4p C 593-620 order
Seq 34-620 Hetero tetramer : IID00616Complex
 Evidence X-RAY 3v4p A Reference
       Region 3v4p A 34-586 order
       Region 3v4p A 587-591 disorder
       Region 3v4p A 592-620 order
Seq 1003-1032 Hetero dimer : IID00061Complex
 Evidence X-RAY 4hkc B Reference
       Region 4hkc B 1003-1005 disorder
       Region 4hkc B 1006-1013 order
       Region 4hkc B 1014-1032 disorder
Seq 1008-1015 Hetero dimer : IID50122Complex
 Evidence X-RAY 5fpi B Reference
       Region 5fpi B 1008-1013 order
       Region 5fpi B 1014-1015 disorder
 Evidence X-RAY 5c7z B Reference
       Region 5c7z B 1008-1013 order
       Region 5c7z B 1014-1015 disorder
Seqphosphorylation
    1021-1021 Phosphoserine
 
Prediction
NeProc
Disorder 1-26,77-80,591-595,870-882,1014-1032
Order 27-76,81-525,530-586,596-869,883-1013
ProS 4-26,870-882,1014-1032
AlphaFold
Disorder 1-33,526-528,538-538,589-594,607-608,620-627,691-694,703-705,714-716,754-760,791-798,862-883,970-974,1004-1032
Order 34-525,529-537,539-588,595-606,609-619,628-690,695-702,706-713,717-753,761-790,799-861,884-969,975-1003
Pfam Hmmer
PF01839 306-342 3.1e-07
PF01839 369-403 3.6e-06
PF08441 463-902 9.1e-146
PF00357 1001-1015 0.00073
SEG 4-18 ,978-996
Function
Function in SwissProt
Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415). ITGA4:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877).
Biological Process
Diagram with PDB data
ITGA4/YWHAZ14-3-3-zeta in complex with S1011 phosphorylated integrin alpha-4 peptide
ITGA4/Ap2m1Mu2 adaptin subunit of the AP2 adaptor (C-terminal domain) complexed with Integrin alpha4 internalisation peptide QYKSILQE
See also
Diagram with PDB data
ITGB7/ FLNACrystal structure of the filamin A repeat 21 complexed with the integrin beta7 cytoplasmic tail peptide