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IID00627
 UniprotP23528
ProteinCofilin-1
GeneCFL1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
166
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-166 Monomer :
 Evidence NMR 1q8x A Reference
       Region 1q8x A 1-166 order
       Region 1q8x A 1-2 high_rmsd
 Evidence NMR 1q8g A Reference
       Region 1q8g A 1-166 order
       Region 1q8g A 1-2 high_rmsd
Seq 1-166 Hetero dimer : P53667
 Evidence X-RAY 5l6w C Reference
       Region 5l6w C 1-1 disorder
       Region 5l6w C 2-166 order
 Evidence X-RAY 5hvk D Reference
       Region 5hvk D 2-165 order
       Region 5hvk D 166-166 disorder
 Evidence X-RAY 5hvk B Reference
       Region 5hvk B 2-166 order
Seq 1-166 Homo dimer :
 Evidence X-RAY 4bex 1 Reference
       Region 4bex 1 1-166 order
Seqphosphorylation
    3-3 Phosphoserine; by NRK
    8-8 Phosphoserine
    25-25 Phosphothreonine
    41-41 Phosphoserine
    63-63 Phosphothreonine
    68-68 Phosphotyrosine
    82-82 Phosphotyrosine
    108-108 Phosphoserine
    140-140 Phosphotyrosine
    156-156 Phosphoserine
Seqacetylation
    2-2 N-acetylalanine
    13-13 N6-acetyllysine
    73-73 N6-acetyllysine
    144-144 N6-acetyllysine
 
Prediction
NeProc
Order 1-166
AlphaFold
Disorder 1-3,22-24
Order 4-21,25-166
Pfam Hmmer
PF00241 19-148 2e-50
Function
Function in SwissProt
Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity (PubMed:11812157). In conjunction with the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (PubMed:15580268). Required for the centralization of the mitotic spindle and symmetric division of zygotes (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization in epithelial cells (PubMed:21834987). Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:23633677). Required for neural tube morphogenesis and neural crest cell migration (By similarity).
Biological Process
See also
Diagram with PDB data
PAK1Crystal structure of PAK1 kinase domain with ruthenium complex lambda-FL172