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IID50063
 UniprotP04911
ProteinHistone H2A.1
GeneHTA1
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
132
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-132 Hetero tetramer : IID50196Complex,IID50290Complex
 Evidence X-RAY 5bt1 C Reference
       Region 5bt1 C 1-16 disorder
       Region 5bt1 C 17-101 order
       Region 5bt1 C 102-132 disorder
Seq 1-132 Hetero nonamer : IID50196Complex
 Evidence X-RAY 4wnn A Reference
       Region 4wnn A 1-16 disorder
       Region 4wnn A 17-102 order
       Region 4wnn A 103-132 disorder
 Evidence X-RAY 4wnn C Reference
       Region 4wnn C 1-17 disorder
       Region 4wnn C 18-100 order
       Region 4wnn C 101-132 disorder
 Evidence X-RAY 4wnn E Reference
       Region 4wnn E 1-17 disorder
       Region 4wnn E 18-100 order
       Region 4wnn E 101-132 disorder
 Evidence X-RAY 4wnn G Reference
       Region 4wnn G 1-17 disorder
       Region 4wnn G 18-99 order
       Region 4wnn G 100-132 disorder
Seq 2-132 Hetero octamer : IID50136Complex,IID50143Complex,P02309
 Evidence X-RAY 1id3 G Reference
       Region 1id3 G 2-13 disorder
       Region 1id3 G 14-121 order
       Region 1id3 G 122-132 disorder
 Evidence X-RAY 1id3 C Reference
       Region 1id3 C 2-16 disorder
       Region 1id3 C 17-126 order
       Region 1id3 C 127-132 disorder
Seq 125-132 Hetero tetramer : IID50173Complex
 Evidence X-RAY 3t7k D Reference
       Region 3t7k D 125-127 disorder
       Region 3t7k D 128-132 order
 Evidence X-RAY 3t7k C Reference
       Region 3t7k C 125-127 disorder
       Region 3t7k C 128-132 order
SeqProS verified 101-121 Hetero octamer : IID50136Complex,IID50143Complex,P02309
       Region 1id3 C 17-126 order
       Region 1id3 G 14-121 order
       Region 4wnn C 101-132 disorder
SeqProS verified 128-132 Hetero tetramer : IID50173Complex
       Region 3t7k C 128-132 order
       Region 3t7k D 128-132 order
       Region 1id3 C 127-132 disorder
Seqphosphorylation
    129-129 Phosphoserine
Seqacetylation
    2-2 N-acetylserine
    5-5 N6-acetyllysine
    8-8 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-24,119-132
Order 25-118
ProS 20-24
AlphaFold
Disorder 1-12,123-132
Order 13-122
Pfam Hmmer
PF00125 19-92 2.1e-30
SEG 2-24 ,55-68
Function
Function in SwissProt
Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Biological Process
See also
Diagram with PDB data
SPT16/HTB1/HTA1SPT16-H2A-H2B FACT HISTONE Complex
SWR1/HTZ1/HTB1Crystal structure of yeast Swr1-Z domain in complex with H2A.Z-H2B dimer