Structure
atLeast majority ProS Experiment
:order disorder conflict PDB cluster ProS Pfam Domain SEG1098
order/disorder by at least rule
disorder by at least rule
order/disorder by majority rule
Seq 31-107 Hetero dimer : IID00169 Complex
Region 2czy A 31-107 order
Region 2czy A 107-107 high_rmsd
Region 2cr7 A 32-98 order
Region 2cr7 A 32-35 high_rmsd
Region 5y95 A 32-98 order
Seq 148-232 Hetero dimer : IID00165 Complex
Region 1pd7 A 148-232 order
Region 1pd7 A 148-149 high_rmsd
Region 1pd7 A 191-198 high_rmsd
Region 1pd7 A 229-232 high_rmsd
Seq 148-232 Hetero dimer : IID00165 Complex
Region 1e91 A 148-232 order
Region 1e91 A 148-149 high_rmsd
Region 1e91 A 192-198 high_rmsd
Region 1e91 A 230-232 high_rmsd
Region 2f05 A 148-232 order
Region 2f05 A 148-149 high_rmsd
Region 2f05 A 192-198 high_rmsd
Region 2f05 A 230-232 high_rmsd
Region 2f05 A 233-252 disorder
Prediction
Function
Function in SwissProt
Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression (PubMed:22476904).
Biological Process
See also Diagram with PDB data MXD1/Sin3b Structure of the complex of the Mad1-Sin3B interaction domains REST/Sin3b Solution structure of the NRSF/REST-mSin3B PAH1 complex
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