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IID50092
 UniprotQ62141
ProteinPaired amphipathic helix protein Sin3b
GeneSin3b
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1098
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 31-107 Hetero dimer : IID00169Complex
 Evidence NMR 2czy A Reference
       Region 2czy A 31-107 order
       Region 2czy A 107-107 high_rmsd
Seq 32-98 Monomer :
 Evidence NMR 2cr7 A Reference
       Region 2cr7 A 32-98 order
       Region 2cr7 A 32-35 high_rmsd
 Evidence NMR 5y95 A Reference
       Region 5y95 A 32-98 order
Seq 148-232 Hetero dimer : IID00165Complex
 Evidence NMR 1pd7 A Reference
       Region 1pd7 A 148-232 order
       Region 1pd7 A 148-149 high_rmsd
       Region 1pd7 A 191-198 high_rmsd
       Region 1pd7 A 229-232 high_rmsd
Seq 148-232 Hetero dimer : IID00165Complex
 Evidence NMR 1e91 A Reference
       Region 1e91 A 148-232 order
       Region 1e91 A 148-149 high_rmsd
       Region 1e91 A 192-198 high_rmsd
       Region 1e91 A 230-232 high_rmsd
Seq 148-252 Monomer :
 Evidence NMR 2f05 A Reference
       Region 2f05 A 148-232 order
       Region 2f05 A 148-149 high_rmsd
       Region 2f05 A 192-198 high_rmsd
       Region 2f05 A 230-232 high_rmsd
       Region 2f05 A 233-252 disorder
Seqphosphorylation
    670-670 Phosphoserine
    667-667 Phosphoserine
 
Prediction
NeProc
Disorder 1-30,85-295,367-369,596-600,673-706,948-978,1029-1039,1094-1098
Order 31-84,296-366,370-595,601-672,707-856,862-913,920-947,979-1028,1040-1093
ProS 85-107,153-185,207-230,367-369,596-600,673-706,948-978,1029-1039
AlphaFold
Disorder 1-33,99-99,105-153,188-200,228-294,358-380,422-436,598-607,660-706,757-777,911-926,928-960,963-997,999-1017,1063-1065,1067-1069,1093-1098
Order 34-98,100-104,154-187,201-227,295-357,381-421,437-597,608-659,707-756,778-910,927-927,961-962,998-998,1018-1062,1066-1066,1070-1092
Pfam Hmmer
PF02671 52-98 1.3e-16
PF02671 172-228 5.9e-13
PF02671 312-358 1.4e-07
PF08295 384-484 8.2e-56
SEG 5-26 ,667-688 ,740-762 ,933-944
Function
Function in SwissProt
Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression (PubMed:22476904).
Biological Process
See also
Diagram with PDB data
MXD1/Sin3bStructure of the complex of the Mad1-Sin3B interaction domains
REST/Sin3bSolution structure of the NRSF/REST-mSin3B PAH1 complex