Search Keyword:


Search option:


IID50143
 UniprotP61830
ProteinHistone H3
GeneHHT1
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
136
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-136 Hetero decamer : IID50067Complex,IID50137Complex,P02309
 Evidence X-RAY 4kud E Reference
       Region 4kud E 1-36 disorder
       Region 4kud E 37-134 order
       Region 4kud E 135-136 disorder
 Evidence X-RAY 4kud A Reference
       Region 4kud A 1-38 disorder
       Region 4kud A 39-134 order
       Region 4kud A 135-136 disorder
Seq 2-5 Hetero dimer : IID50141Complex,IID90020Complex
 Evidence X-RAY 3mp6 P Reference
       Region 3mp6 P 2-5 order
Seq 2-6
 Evidence X-RAY 3mp1 P Reference
       Region 3mp1 P 2-6 order
Seq 2-6 Hetero dimer : IID00377Complex
 Evidence X-RAY 2cnx P Reference
       Region 2cnx P 2-6 order
Seq 2-10 Hetero dimer : IID50148Complex
 Evidence NMR 2jmj P Reference
       Region 2jmj P 2-10 order
Seq 2-15 Hetero hexamer : IID50212Complex,IID50225Complex
 Evidence X-RAY 3q33 D Reference
       Region 3q33 D 2-11 disorder
       Region 3q33 D 12-15 order
Seq 2-16 Hetero tetramer : P39984
 Evidence X-RAY 4psx P Reference
       Region 4psx P 2-11 order
       Region 4psx P 12-16 disorder
 Evidence X-RAY 4psx Y Reference
       Region 4psx Y 2-13 order
       Region 4psx Y 14-16 disorder
Seq 2-16
 Evidence X-RAY 1peg P Reference
       Region 1peg P 2-7 disorder
       Region 1peg P 8-14 order
       Region 1peg P 15-16 disorder
Seq 2-16
 Evidence X-RAY 1peg Q Reference
       Region 1peg Q 2-7 disorder
       Region 1peg Q 8-12 order
       Region 1peg Q 13-16 disorder
Seq 2-16 Hetero dimer : IID00390Complex
 Evidence NMR 2rnw B Reference
       Region 2rnw B 2-16 order
Seq 2-18 Hetero dimer : IID50149Complex
 Evidence NMR 2rsn B Reference
       Region 2rsn B 2-18 order
Seq 2-21 Hetero dimer :
 Evidence X-RAY 1m1d D Reference
       Region 1m1d D 2-21 disorder
Seq 2-24 Hetero dimer : IID50128Complex
 Evidence X-RAY 1qsn B Reference
       Region 1qsn B 10-20 order
 Evidence X-RAY 1pua B Reference
       Region 1pua B 6-24 order
 Evidence X-RAY 1pu9 B Reference
       Region 1pu9 B 6-7 disorder
       Region 1pu9 B 8-22 order
       Region 1pu9 B 23-24 disorder
 Evidence X-RAY 1m1d B Reference
       Region 1m1d B 2-12 disorder
       Region 1m1d B 13-18 order
       Region 1m1d B 19-21 disorder
Seq 2-136 Hetero octamer : IID50063Complex,P02309
 Evidence X-RAY 1id3 E Reference
       Region 1id3 E 2-38 disorder
       Region 1id3 E 39-135 order
       Region 1id3 E 136-136 disorder
 Evidence X-RAY 1id3 A Reference
       Region 1id3 A 2-38 disorder
       Region 1id3 A 39-135 order
       Region 1id3 A 136-136 disorder
Seq 2-136 Hetero decamer : IID50067Complex,IID50137Complex,P02309
 Evidence X-RAY 4jjn E Reference
       Region 4jjn E 2-39 disorder
       Region 4jjn E 40-135 order
       Region 4jjn E 136-136 disorder
 Evidence X-RAY 4jjn A Reference
       Region 4jjn A 2-38 disorder
       Region 4jjn A 39-136 order
Seq 6-12 Hetero dimer : IID50207Complex
 Evidence X-RAY 5iok C Reference
       Region 5iok C 6-12 order
 Evidence X-RAY 5d7e C Reference
       Region 5d7e C 6-12 order
Seq 32-43 Hetero dimer : IID00390Complex
 Evidence NMR 2rnx B Reference
       Region 2rnx B 32-43 order
Seq 114-124 Hetero dimer : IID90011Complex
 Evidence X-RAY 2h2g B Reference
       Region 2h2g B 114-118 order
       Region 2h2g B 119-124 disorder
Seq 119-135 Monomer : IID50170Complex
 Evidence X-RAY 2idc A Reference
       Region 2idc A 119-122 disorder
       Region 2idc A 123-132 order
       Region 2idc A 133-135 disorder
SeqProS verified 2-5 Hetero dimer : IID50141Complex,IID90020Complex
       Region 3mp6 P 2-5 order
       Region 1id3 A 2-38 disorder
SeqProS verified 2-6 Hetero dimer : IID00377Complex
       Region 2cnx P 2-6 order
       Region 1id3 A 2-38 disorder
SeqProS verified 2-10 Hetero dimer : IID50148Complex
       Region 2jmj P 2-10 order
       Region 1id3 A 2-38 disorder
SeqProS verified 2-13 Hetero tetramer : P39984
       Region 4psx P 2-11 order
       Region 4psx Y 2-13 order
       Region 1id3 A 2-38 disorder
SeqProS verified 2-16 Hetero dimer : IID00390Complex
       Region 2rnw B 2-16 order
       Region 1id3 A 2-38 disorder
SeqProS verified 2-18 Hetero dimer : IID50149Complex
       Region 2rsn B 2-18 order
       Region 1id3 A 2-38 disorder
SeqProS verified 6-12 Hetero dimer : IID50207Complex
       Region 5d7e C 6-12 order
       Region 5iok C 6-12 order
       Region 1id3 A 2-38 disorder
SeqProS verified 10-20 Hetero dimer : IID50128Complex
       Region 1qsn B 10-20 order
       Region 1pua B 6-24 order
       Region 1pu9 B 8-22 order
       Region 1id3 A 2-38 disorder
SeqProS verified 12-15 Hetero hexamer : IID50212Complex,IID50225Complex
       Region 3q33 D 12-15 order
       Region 1id3 A 2-38 disorder
Seqphosphorylation
    11-11 Phosphoserine
Seqacetylation
    38-38 N6-acetyllysine; alternate
    57-57 N6-acetyllysine
    65-65 N6-acetyllysine
    10-10 N6-acetyllysine; alternate
    15-15 N6-acetyllysine; alternate
    19-19 N6-acetyllysine; alternate
    37-37 N6-acetyllysine; alternate
    24-24 N6-acetyllysine; alternate
    28-28 N6-acetyllysine; alternate
 
Prediction
NeProc
Disorder 1-36
Order 37-136
ProS 1-36
AlphaFold
Disorder 1-3,6-35,135-136
Order 4-5,36-134
Pfam Hmmer
PF00125 58-132 2.7e-36
Function
Function in SwissProt
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Component of the UAF (upstream activation factor) complex which interacts with the upstream element of the RNA polymerase I promoter and forms a stable preinitiation complex. Together with SPT15/TBP, UAF seems to stimulate basal transcription to a fully activated level.
Biological Process
See also
Diagram with PDB data
SPT16/HTB1/HTA1SPT16-H2A-H2B FACT HISTONE Complex
SWR1/HTZ1/HTB1Crystal structure of yeast Swr1-Z domain in complex with H2A.Z-H2B dimer