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IID50154
 UniprotQ8T5C6
ProteinRetinoic acid receptor RXR
GeneRXR
OrganismBiomphalaria glabrata
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
436
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 207-436 Hetero octamer : IID00083Complex
 Evidence X-RAY 1xiu B Reference
       Region 1xiu B 207-208 disorder
       Region 1xiu B 209-432 order
       Region 1xiu B 433-436 disorder
 Evidence X-RAY 1xiu A Reference
       Region 1xiu A 207-209 disorder
       Region 1xiu A 210-430 order
       Region 1xiu A 431-436 disorder
 
Prediction
NeProc
Disorder 1-113,185-212,434-436
Order 114-184,213-433
ProS 4-12,33-38,185-194,434-436
AlphaFold
Disorder 1-113,192-209,229-236,415-422,424-426,429-436
Order 114-191,210-228,237-414,423-423,427-428
Pfam Hmmer
PF00105 115-190 2.1e-50
PF00104 247-428 2e-68
SEG 13-33 ,85-112
Function
Function in SwissProt
Ligand-dependent transcription factor probably involved in the retinoic acid response pathway. Binds 9-cis-retinoic acid (9C-RA) and, to a lesser extent, docosahexaenoic acid (DHA), phytanic acid, methoprene acid and oleic acid. Binds to double-stranded DNA sequences containing direct repeats (DR) with the consensus sequence 5'-[AG]GGTCA-3' and 1, 2, 3, 4 or 5 nucleotides in between (DR1, DR2, DR3. DR4 and DR5, respectively). Binding to DR1 is strongest. Transactivates gene expression when 9C-RA or DHA is bound.