Search Keyword:


Search option:


IID50196
 UniprotP02293
ProteinHistone H2B.1
GeneHTB1
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
131
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-131 Hetero tetramer : IID50063Complex,IID50290Complex
 Evidence X-RAY 5bt1 D Reference
       Region 5bt1 D 1-37 disorder
       Region 5bt1 D 38-127 order
       Region 5bt1 D 128-131 disorder
Seq 1-131 Hetero decamer : IID50067Complex,IID50137Complex,P02309
 Evidence X-RAY 4kud H Reference
       Region 4kud H 1-36 disorder
       Region 4kud H 37-130 order
       Region 4kud H 131-131 disorder
 Evidence X-RAY 4kud D Reference
       Region 4kud D 1-37 disorder
       Region 4kud D 38-130 order
       Region 4kud D 131-131 disorder
Seq 31-131 Hetero nonamer : IID50063Complex,IID50313Complex
 Evidence X-RAY 4wnn B Reference
       Region 4wnn B 31-127 order
       Region 4wnn B 128-131 disorder
 Evidence X-RAY 4wnn D Reference
       Region 4wnn D 31-127 order
       Region 4wnn D 128-131 disorder
 Evidence X-RAY 4wnn F Reference
       Region 4wnn F 31-127 order
       Region 4wnn F 128-131 disorder
 Evidence X-RAY 4wnn H Reference
       Region 4wnn H 31-127 order
       Region 4wnn H 128-131 disorder
Seq 37-131 Hetero dimer : IID50223Complex,IID50226Complex
 Evidence X-RAY 4m6b A Reference
       Region 4m6b A 37-37 disorder
       Region 4m6b A 38-131 order
Seq 37-131 Hetero dimer : IID50223Complex,IID50226Complex
 Evidence X-RAY 4m6b D Reference
       Region 4m6b D 37-131 order
Seq 37-131 Hetero dimer : IID50210Complex,IID50226Complex
 Evidence NMR 2jss A Reference
       Region 2jss A 37-131 order
       Region 2jss A 37-37 high_rmsd
Seqphosphorylation
    11-11 Phosphoserine
Seqacetylation
    23-23 N6-acetyllysine; alternate
    22-22 N6-acetyllysine; alternate
    18-18 N6-acetyllysine; alternate
    17-17 N6-acetyllysine; alternate
    12-12 N6-acetyllysine
    8-8 N6-acetyllysine; alternate
    7-7 N6-acetyllysine; alternate
 
Prediction
NeProc
Disorder 1-39,125-131
Order 40-124
ProS 34-39,125-128
AlphaFold
Disorder 1-35,131-131
Order 36-130
Pfam Hmmer
PF00125 35-105 1e-24
SEG 3-28
Function
Function in SwissProt
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Biological Process
See also
Diagram with PDB data
SPT16/HTB1/HTA1SPT16-H2A-H2B FACT HISTONE Complex
SWR1/HTZ1/HTB1Crystal structure of yeast Swr1-Z domain in complex with H2A.Z-H2B dimer