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IID50311
UniprotP19619
ProteinAnnexin A1
GeneANXA1
OrganismSus scrofa
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
xml
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
346
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-346 Monomer :
 Evidence X-RAY 1mcx A Reference
       Region 1mcx A 1-40 disorder
       Region 1mcx A 41-344 order
       Region 1mcx A 345-346 disorder
 Evidence X-RAY 1hm6 B Reference
       Region 1hm6 B 1-1 disorder
       Region 1hm6 B 2-344 order
       Region 1hm6 B 345-346 disorder
 Evidence X-RAY 1hm6 A Reference
       Region 1hm6 A 1-1 disorder
       Region 1hm6 A 2-344 order
       Region 1hm6 A 345-346 disorder
SeqProS verified 2-40 :
       Region 1hm6 A 2-344 order
       Region 1hm6 B 2-344 order
       Region 1mcx A 1-40 disorder
Seqphosphorylation
    37-37 Phosphoserine
    41-41 Phosphothreonine
    136-136 Phosphothreonine
    21-21 Phosphotyrosine; by EGFR
    34-34 Phosphoserine
    5-5 Phosphoserine; by TRPM7
Seqacetylation
    312-312 N6-acetyllysine
    239-239 N6-acetyllysine
    58-58 N6-acetyllysine
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 16-30
Order 1-15,31-346
ProS 16-21
AlphaFold
Disorder 1-1,247-247,249-249
Order 2-246,248-248,250-346
Pfam Hmmer
PF00191 46-111 1.7e-21
PF00191 118-183 1.3e-32
PF00191 201-267 4.7e-20
PF00191 277-342 3.7e-32
Function
Function in SwissProt
Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells. Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (By similarity). Has no effect on unstimulated T-cells. Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration. Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (By similarity). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (PubMed:12595246). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:8885232). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity).
Biological Process
Diagram with PDB data
ANXA1X-RAY STRUCTURE OF FULL-LENGTH ANNEXIN 1