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IID90040
 UniprotQ99ZW2
ProteinCRISPR-associated endonuclease Cas9/Csn1
Genecas9
OrganismStreptococcus pyogenes serotype M1
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1368
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-1368 Homo dimer :
 Evidence X-RAY 6aeb B Reference
       Region 6aeb B 1-3 disorder
       Region 6aeb B 4-712 order
       Region 6aeb B 713-718 disorder
       Region 6aeb B 719-765 order
       Region 6aeb B 766-776 disorder
       Region 6aeb B 777-1011 order
       Region 6aeb B 1012-1030 disorder
       Region 6aeb B 1031-1243 order
       Region 6aeb B 1244-1248 disorder
       Region 6aeb B 1249-1366 order
       Region 6aeb B 1367-1368 disorder
 Evidence X-RAY 6aeb F Reference
       Region 6aeb F 1-3 disorder
       Region 6aeb F 4-712 order
       Region 6aeb F 713-718 disorder
       Region 6aeb F 719-765 order
       Region 6aeb F 766-776 disorder
       Region 6aeb F 777-1011 order
       Region 6aeb F 1012-1030 disorder
       Region 6aeb F 1031-1243 order
       Region 6aeb F 1244-1248 disorder
       Region 6aeb F 1249-1366 order
       Region 6aeb F 1367-1368 disorder
 Evidence X-RAY 7z4d B Reference
       Region 7z4d B 1-1 disorder
       Region 7z4d B 2-179 order
       Region 7z4d B 180-180 disorder
       Region 7z4d B 181-716 order
       Region 7z4d B 717-717 disorder
       Region 7z4d B 718-764 order
       Region 7z4d B 765-839 disorder
       Region 7z4d B 840-854 order
       Region 7z4d B 855-866 disorder
       Region 7z4d B 867-878 order
       Region 7z4d B 879-892 disorder
       Region 7z4d B 893-903 order
       Region 7z4d B 904-908 disorder
       Region 7z4d B 909-1368 order
 Evidence X-RAY 7z4d E Reference
       Region 7z4d E 1-1 disorder
       Region 7z4d E 2-526 order
       Region 7z4d E 527-543 disorder
       Region 7z4d E 544-553 order
       Region 7z4d E 554-563 disorder
       Region 7z4d E 564-575 order
       Region 7z4d E 576-589 disorder
       Region 7z4d E 590-668 order
       Region 7z4d E 669-669 disorder
       Region 7z4d E 670-685 order
       Region 7z4d E 686-688 disorder
       Region 7z4d E 689-698 order
       Region 7z4d E 699-717 disorder
       Region 7z4d E 718-764 order
       Region 7z4d E 765-839 disorder
       Region 7z4d E 840-855 order
       Region 7z4d E 856-908 disorder
       Region 7z4d E 909-1017 order
       Region 7z4d E 1018-1020 disorder
       Region 7z4d E 1021-1028 order
       Region 7z4d E 1029-1034 disorder
       Region 7z4d E 1035-1368 order
Seq 1-1368 Hetero tetramer :
 Evidence X-RAY 6ifo B Reference
       Region 6ifo B 1-714 order
       Region 6ifo B 715-717 disorder
       Region 6ifo B 718-770 order
       Region 6ifo B 771-773 disorder
       Region 6ifo B 774-1029 order
       Region 6ifo B 1030-1032 disorder
       Region 6ifo B 1033-1368 order
 Evidence X-RAY 6ifo A Reference
       Region 6ifo A 1-714 order
       Region 6ifo A 715-717 disorder
       Region 6ifo A 718-770 order
       Region 6ifo A 771-773 disorder
       Region 6ifo A 774-1029 order
       Region 6ifo A 1030-1032 disorder
       Region 6ifo A 1033-1368 order
Seq 1-1368 Hetero dimer : A0A0E0UT28
 Evidence X-RAY 5vw1 A Reference
       Region 5vw1 A 1-714 order
       Region 5vw1 A 715-717 disorder
       Region 5vw1 A 718-772 order
       Region 5vw1 A 773-773 disorder
       Region 5vw1 A 774-1029 order
       Region 5vw1 A 1030-1032 disorder
       Region 5vw1 A 1033-1368 order
Seq 1-1368 Monomer :
 Evidence X-RAY 4cmp A Reference
       Region 4cmp A 1-3 disorder
       Region 4cmp A 4-102 order
       Region 4cmp A 103-114 disorder
       Region 4cmp A 115-307 order
       Region 4cmp A 308-313 disorder
       Region 4cmp A 314-447 order
       Region 4cmp A 448-502 disorder
       Region 4cmp A 503-527 order
       Region 4cmp A 528-539 disorder
       Region 4cmp A 540-567 order
       Region 4cmp A 568-586 disorder
       Region 4cmp A 587-672 order
       Region 4cmp A 673-676 disorder
       Region 4cmp A 677-684 order
       Region 4cmp A 685-690 disorder
       Region 4cmp A 691-714 order
       Region 4cmp A 715-717 disorder
       Region 4cmp A 718-764 order
       Region 4cmp A 765-774 disorder
       Region 4cmp A 775-791 order
       Region 4cmp A 792-798 disorder
       Region 4cmp A 799-859 order
       Region 4cmp A 860-861 disorder
       Region 4cmp A 862-902 order
       Region 4cmp A 903-907 disorder
       Region 4cmp A 908-1027 order
       Region 4cmp A 1028-1035 disorder
       Region 4cmp A 1036-1102 order
       Region 4cmp A 1103-1136 disorder
       Region 4cmp A 1137-1146 order
       Region 4cmp A 1147-1158 disorder
       Region 4cmp A 1159-1186 order
       Region 4cmp A 1187-1191 disorder
       Region 4cmp A 1192-1242 order
       Region 4cmp A 1243-1258 disorder
       Region 4cmp A 1259-1363 order
       Region 4cmp A 1364-1368 disorder
 Evidence X-RAY 4cmp B Reference
       Region 4cmp B 1-3 disorder
       Region 4cmp B 4-103 order
       Region 4cmp B 104-115 disorder
       Region 4cmp B 116-308 order
       Region 4cmp B 309-309 disorder
       Region 4cmp B 310-447 order
       Region 4cmp B 448-501 disorder
       Region 4cmp B 502-527 order
       Region 4cmp B 528-538 disorder
       Region 4cmp B 539-570 order
       Region 4cmp B 571-586 disorder
       Region 4cmp B 587-673 order
       Region 4cmp B 674-675 disorder
       Region 4cmp B 676-713 order
       Region 4cmp B 714-717 disorder
       Region 4cmp B 718-764 order
       Region 4cmp B 765-772 disorder
       Region 4cmp B 773-791 order
       Region 4cmp B 792-799 disorder
       Region 4cmp B 800-859 order
       Region 4cmp B 860-861 disorder
       Region 4cmp B 862-902 order
       Region 4cmp B 903-907 disorder
       Region 4cmp B 908-1025 order
       Region 4cmp B 1026-1035 disorder
       Region 4cmp B 1036-1102 order
       Region 4cmp B 1103-1136 disorder
       Region 4cmp B 1137-1148 order
       Region 4cmp B 1149-1159 disorder
       Region 4cmp B 1160-1185 order
       Region 4cmp B 1186-1187 disorder
       Region 4cmp B 1188-1241 order
       Region 4cmp B 1242-1255 disorder
       Region 4cmp B 1256-1363 order
       Region 4cmp B 1364-1368 disorder
 Evidence X-RAY 4cmq A Reference
       Region 4cmq A 1-3 disorder
       Region 4cmq A 4-102 order
       Region 4cmq A 103-114 disorder
       Region 4cmq A 115-307 order
       Region 4cmq A 308-313 disorder
       Region 4cmq A 314-447 order
       Region 4cmq A 448-502 disorder
       Region 4cmq A 503-532 order
       Region 4cmq A 533-538 disorder
       Region 4cmq A 539-570 order
       Region 4cmq A 571-578 disorder
       Region 4cmq A 579-672 order
       Region 4cmq A 673-676 disorder
       Region 4cmq A 677-684 order
       Region 4cmq A 685-690 disorder
       Region 4cmq A 691-714 order
       Region 4cmq A 715-717 disorder
       Region 4cmq A 718-766 order
       Region 4cmq A 767-773 disorder
       Region 4cmq A 774-791 order
       Region 4cmq A 792-798 disorder
       Region 4cmq A 799-831 order
       Region 4cmq A 832-837 disorder
       Region 4cmq A 838-859 order
       Region 4cmq A 860-862 disorder
       Region 4cmq A 863-902 order
       Region 4cmq A 903-907 disorder
       Region 4cmq A 908-1026 order
       Region 4cmq A 1027-1035 disorder
       Region 4cmq A 1036-1102 order
       Region 4cmq A 1103-1136 disorder
       Region 4cmq A 1137-1146 order
       Region 4cmq A 1147-1158 disorder
       Region 4cmq A 1159-1186 order
       Region 4cmq A 1187-1191 disorder
       Region 4cmq A 1192-1242 order
       Region 4cmq A 1243-1258 disorder
       Region 4cmq A 1259-1363 order
       Region 4cmq A 1364-1368 disorder
 Evidence X-RAY 4cmq B Reference
       Region 4cmq B 1-3 disorder
       Region 4cmq B 4-103 order
       Region 4cmq B 104-115 disorder
       Region 4cmq B 116-308 order
       Region 4cmq B 309-309 disorder
       Region 4cmq B 310-405 order
       Region 4cmq B 406-406 disorder
       Region 4cmq B 407-447 order
       Region 4cmq B 448-501 disorder
       Region 4cmq B 502-531 order
       Region 4cmq B 532-538 disorder
       Region 4cmq B 539-570 order
       Region 4cmq B 571-586 disorder
       Region 4cmq B 587-673 order
       Region 4cmq B 674-675 disorder
       Region 4cmq B 676-713 order
       Region 4cmq B 714-717 disorder
       Region 4cmq B 718-766 order
       Region 4cmq B 767-774 disorder
       Region 4cmq B 775-791 order
       Region 4cmq B 792-797 disorder
       Region 4cmq B 798-835 order
       Region 4cmq B 836-837 disorder
       Region 4cmq B 838-859 order
       Region 4cmq B 860-862 disorder
       Region 4cmq B 863-902 order
       Region 4cmq B 903-907 disorder
       Region 4cmq B 908-1025 order
       Region 4cmq B 1026-1035 disorder
       Region 4cmq B 1036-1102 order
       Region 4cmq B 1103-1136 disorder
       Region 4cmq B 1137-1148 order
       Region 4cmq B 1149-1159 disorder
       Region 4cmq B 1160-1185 order
       Region 4cmq B 1186-1188 disorder
       Region 4cmq B 1189-1241 order
       Region 4cmq B 1242-1254 disorder
       Region 4cmq B 1255-1363 order
       Region 4cmq B 1364-1368 disorder
 Evidence X-RAY 4oo8 A Reference
       Region 4oo8 A 1-2 disorder
       Region 4oo8 A 3-307 order
       Region 4oo8 A 308-313 disorder
       Region 4oo8 A 314-713 order
       Region 4oo8 A 714-717 disorder
       Region 4oo8 A 718-769 order
       Region 4oo8 A 770-774 disorder
       Region 4oo8 A 775-793 order
       Region 4oo8 A 794-801 disorder
       Region 4oo8 A 802-941 order
       Region 4oo8 A 942-949 disorder
       Region 4oo8 A 950-1016 order
       Region 4oo8 A 1017-1028 disorder
       Region 4oo8 A 1029-1048 order
       Region 4oo8 A 1049-1062 disorder
       Region 4oo8 A 1063-1242 order
       Region 4oo8 A 1243-1248 disorder
       Region 4oo8 A 1249-1366 order
       Region 4oo8 A 1367-1368 disorder
 Evidence X-RAY 4oo8 D Reference
       Region 4oo8 D 1-2 disorder
       Region 4oo8 D 3-713 order
       Region 4oo8 D 714-717 disorder
       Region 4oo8 D 718-765 order
       Region 4oo8 D 766-918 disorder
       Region 4oo8 D 919-1012 order
       Region 4oo8 D 1013-1037 disorder
       Region 4oo8 D 1038-1047 order
       Region 4oo8 D 1048-1061 disorder
       Region 4oo8 D 1062-1243 order
       Region 4oo8 D 1244-1248 disorder
       Region 4oo8 D 1249-1366 order
       Region 4oo8 D 1367-1368 disorder
 Evidence X-RAY 4un3 B Reference
       Region 4un3 B 1-3 disorder
       Region 4un3 B 4-384 order
       Region 4un3 B 385-385 disorder
       Region 4un3 B 386-710 order
       Region 4un3 B 711-718 disorder
       Region 4un3 B 719-765 order
       Region 4un3 B 766-775 disorder
       Region 4un3 B 776-1012 order
       Region 4un3 B 1013-1029 disorder
       Region 4un3 B 1030-1050 order
       Region 4un3 B 1051-1058 disorder
       Region 4un3 B 1059-1241 order
       Region 4un3 B 1242-1252 disorder
       Region 4un3 B 1253-1364 order
       Region 4un3 B 1365-1368 disorder
 Evidence X-RAY 4un4 B Reference
       Region 4un4 B 1-3 disorder
       Region 4un4 B 4-176 order
       Region 4un4 B 177-179 disorder
       Region 4un4 B 180-712 order
       Region 4un4 B 713-717 disorder
       Region 4un4 B 718-765 order
       Region 4un4 B 766-774 disorder
       Region 4un4 B 775-1012 order
       Region 4un4 B 1013-1029 disorder
       Region 4un4 B 1030-1050 order
       Region 4un4 B 1051-1058 disorder
       Region 4un4 B 1059-1241 order
       Region 4un4 B 1242-1250 disorder
       Region 4un4 B 1251-1364 order
       Region 4un4 B 1365-1368 disorder
 Evidence X-RAY 4un5 B Reference
       Region 4un5 B 1-3 disorder
       Region 4un5 B 4-176 order
       Region 4un5 B 177-179 disorder
       Region 4un5 B 180-712 order
       Region 4un5 B 713-717 disorder
       Region 4un5 B 718-765 order
       Region 4un5 B 766-774 disorder
       Region 4un5 B 775-1012 order
       Region 4un5 B 1013-1029 disorder
       Region 4un5 B 1030-1050 order
       Region 4un5 B 1051-1058 disorder
       Region 4un5 B 1059-1241 order
       Region 4un5 B 1242-1250 disorder
       Region 4un5 B 1251-1364 order
       Region 4un5 B 1365-1368 disorder
 Evidence X-RAY 4zt0 A Reference
       Region 4zt0 A 1-2 disorder
       Region 4zt0 A 3-1366 order
       Region 4zt0 A 1367-1368 disorder
 Evidence X-RAY 4zt0 C Reference
       Region 4zt0 C 1-3 disorder
       Region 4zt0 C 4-766 order
       Region 4zt0 C 767-774 disorder
       Region 4zt0 C 775-801 order
       Region 4zt0 C 802-808 disorder
       Region 4zt0 C 809-831 order
       Region 4zt0 C 832-833 disorder
       Region 4zt0 C 834-866 order
       Region 4zt0 C 867-870 disorder
       Region 4zt0 C 871-884 order
       Region 4zt0 C 885-891 disorder
       Region 4zt0 C 892-899 order
       Region 4zt0 C 900-906 disorder
       Region 4zt0 C 907-946 order
       Region 4zt0 C 947-952 disorder
       Region 4zt0 C 953-1019 order
       Region 4zt0 C 1020-1039 disorder
       Region 4zt0 C 1040-1050 order
       Region 4zt0 C 1051-1056 disorder
       Region 4zt0 C 1057-1366 order
       Region 4zt0 C 1367-1368 disorder
 Evidence X-RAY 4zt9 A Reference
       Region 4zt9 A 1-2 disorder
       Region 4zt9 A 3-307 order
       Region 4zt9 A 308-313 disorder
       Region 4zt9 A 314-710 order
       Region 4zt9 A 711-717 disorder
       Region 4zt9 A 718-764 order
       Region 4zt9 A 765-776 disorder
       Region 4zt9 A 777-1027 order
       Region 4zt9 A 1028-1033 disorder
       Region 4zt9 A 1034-1368 order
 Evidence X-RAY 4zt9 C Reference
       Region 4zt9 C 1-3 disorder
       Region 4zt9 C 4-307 order
       Region 4zt9 C 308-313 disorder
       Region 4zt9 C 314-526 order
       Region 4zt9 C 527-538 disorder
       Region 4zt9 C 539-571 order
       Region 4zt9 C 572-579 disorder
       Region 4zt9 C 580-695 order
       Region 4zt9 C 696-699 disorder
       Region 4zt9 C 700-765 order
       Region 4zt9 C 766-838 disorder
       Region 4zt9 C 839-854 order
       Region 4zt9 C 855-906 disorder
       Region 4zt9 C 907-946 order
       Region 4zt9 C 947-952 disorder
       Region 4zt9 C 953-1010 order
       Region 4zt9 C 1011-1038 disorder
       Region 4zt9 C 1039-1050 order
       Region 4zt9 C 1051-1056 disorder
       Region 4zt9 C 1057-1244 order
       Region 4zt9 C 1245-1252 disorder
       Region 4zt9 C 1253-1366 order
       Region 4zt9 C 1367-1368 disorder
 Evidence X-RAY 5b2r B Reference
       Region 5b2r B 1-3 disorder
       Region 5b2r B 4-178 order
       Region 5b2r B 179-183 disorder
       Region 5b2r B 184-712 order
       Region 5b2r B 713-717 disorder
       Region 5b2r B 718-765 order
       Region 5b2r B 766-775 disorder
       Region 5b2r B 776-1011 order
       Region 5b2r B 1012-1030 disorder
       Region 5b2r B 1031-1243 order
       Region 5b2r B 1244-1248 disorder
       Region 5b2r B 1249-1366 order
       Region 5b2r B 1367-1368 disorder
 Evidence X-RAY 5b2s B Reference
       Region 5b2s B 1-3 disorder
       Region 5b2s B 4-178 order
       Region 5b2s B 179-183 disorder
       Region 5b2s B 184-712 order
       Region 5b2s B 713-717 disorder
       Region 5b2s B 718-765 order
       Region 5b2s B 766-775 disorder
       Region 5b2s B 776-1011 order
       Region 5b2s B 1012-1030 disorder
       Region 5b2s B 1031-1243 order
       Region 5b2s B 1244-1248 disorder
       Region 5b2s B 1249-1366 order
       Region 5b2s B 1367-1368 disorder
 Evidence X-RAY 5b2t B Reference
       Region 5b2t B 1-2 disorder
       Region 5b2t B 3-712 order
       Region 5b2t B 713-717 disorder
       Region 5b2t B 718-765 order
       Region 5b2t B 766-775 disorder
       Region 5b2t B 776-800 order
       Region 5b2t B 801-802 disorder
       Region 5b2t B 803-1012 order
       Region 5b2t B 1013-1029 disorder
       Region 5b2t B 1030-1244 order
       Region 5b2t B 1245-1248 disorder
       Region 5b2t B 1249-1366 order
       Region 5b2t B 1367-1368 disorder
 Evidence X-RAY 5f9r B Reference
       Region 5f9r B 1-2 disorder
       Region 5f9r B 3-1364 order
       Region 5f9r B 1365-1368 disorder
 Evidence X-RAY 5fq5 B Reference
       Region 5fq5 B 1-3 disorder
       Region 5fq5 B 4-175 order
       Region 5fq5 B 176-178 disorder
       Region 5fq5 B 179-713 order
       Region 5fq5 B 714-717 disorder
       Region 5fq5 B 718-766 order
       Region 5fq5 B 767-774 disorder
       Region 5fq5 B 775-1012 order
       Region 5fq5 B 1013-1029 disorder
       Region 5fq5 B 1030-1050 order
       Region 5fq5 B 1051-1058 disorder
       Region 5fq5 B 1059-1243 order
       Region 5fq5 B 1244-1246 disorder
       Region 5fq5 B 1247-1364 order
       Region 5fq5 B 1365-1368 disorder
 Evidence X-RAY 5fw1 B Reference
       Region 5fw1 B 1-3 disorder
       Region 5fw1 B 4-177 order
       Region 5fw1 B 178-178 disorder
       Region 5fw1 B 179-179 order
       Region 5fw1 B 180-180 disorder
       Region 5fw1 B 181-384 order
       Region 5fw1 B 385-385 disorder
       Region 5fw1 B 386-710 order
       Region 5fw1 B 711-718 disorder
       Region 5fw1 B 719-765 order
       Region 5fw1 B 766-775 disorder
       Region 5fw1 B 776-1012 order
       Region 5fw1 B 1013-1029 disorder
       Region 5fw1 B 1030-1050 order
       Region 5fw1 B 1051-1058 disorder
       Region 5fw1 B 1059-1241 order
       Region 5fw1 B 1242-1252 disorder
       Region 5fw1 B 1253-1364 order
       Region 5fw1 B 1365-1368 disorder
 Evidence X-RAY 5fw2 B Reference
       Region 5fw2 B 1-2 disorder
       Region 5fw2 B 3-713 order
       Region 5fw2 B 714-717 disorder
       Region 5fw2 B 718-765 order
       Region 5fw2 B 766-774 disorder
       Region 5fw2 B 775-1012 order
       Region 5fw2 B 1013-1029 disorder
       Region 5fw2 B 1030-1051 order
       Region 5fw2 B 1052-1058 disorder
       Region 5fw2 B 1059-1241 order
       Region 5fw2 B 1242-1251 disorder
       Region 5fw2 B 1252-1365 order
       Region 5fw2 B 1366-1368 disorder
 Evidence X-RAY 5fw3 B Reference
       Region 5fw3 B 1-2 disorder
       Region 5fw3 B 3-712 order
       Region 5fw3 B 713-717 disorder
       Region 5fw3 B 718-766 order
       Region 5fw3 B 767-775 disorder
       Region 5fw3 B 776-1012 order
       Region 5fw3 B 1013-1027 disorder
       Region 5fw3 B 1028-1053 order
       Region 5fw3 B 1054-1055 disorder
       Region 5fw3 B 1056-1241 order
       Region 5fw3 B 1242-1251 disorder
       Region 5fw3 B 1252-1365 order
       Region 5fw3 B 1366-1368 disorder
 Evidence X-RAY 6aeg B Reference
       Region 6aeg B 1-3 disorder
       Region 6aeg B 4-712 order
       Region 6aeg B 713-718 disorder
       Region 6aeg B 719-765 order
       Region 6aeg B 766-776 disorder
       Region 6aeg B 777-1011 order
       Region 6aeg B 1012-1030 disorder
       Region 6aeg B 1031-1243 order
       Region 6aeg B 1244-1248 disorder
       Region 6aeg B 1249-1366 order
       Region 6aeg B 1367-1368 disorder
 Evidence X-RAY 6ai6 A Reference
       Region 6ai6 A 1-2 disorder
       Region 6ai6 A 3-712 order
       Region 6ai6 A 713-717 disorder
       Region 6ai6 A 718-765 order
       Region 6ai6 A 766-775 disorder
       Region 6ai6 A 776-1011 order
       Region 6ai6 A 1012-1031 disorder
       Region 6ai6 A 1032-1242 order
       Region 6ai6 A 1243-1249 disorder
       Region 6ai6 A 1250-1366 order
       Region 6ai6 A 1367-1368 disorder
 Evidence X-RAY 6k3z B Reference
       Region 6k3z B 1-3 disorder
       Region 6k3z B 4-384 order
       Region 6k3z B 385-385 disorder
       Region 6k3z B 386-713 order
       Region 6k3z B 714-718 disorder
       Region 6k3z B 719-765 order
       Region 6k3z B 766-775 disorder
       Region 6k3z B 776-1012 order
       Region 6k3z B 1013-1029 disorder
       Region 6k3z B 1030-1050 order
       Region 6k3z B 1051-1058 disorder
       Region 6k3z B 1059-1242 order
       Region 6k3z B 1243-1247 disorder
       Region 6k3z B 1248-1364 order
       Region 6k3z B 1365-1368 disorder
 Evidence X-RAY 6k4p B Reference
       Region 6k4p B 1-2 disorder
       Region 6k4p B 3-714 order
       Region 6k4p B 715-718 disorder
       Region 6k4p B 719-765 order
       Region 6k4p B 766-773 disorder
       Region 6k4p B 774-1011 order
       Region 6k4p B 1012-1029 disorder
       Region 6k4p B 1030-1050 order
       Region 6k4p B 1051-1058 disorder
       Region 6k4p B 1059-1244 order
       Region 6k4p B 1245-1248 disorder
       Region 6k4p B 1249-1367 order
       Region 6k4p B 1368-1368 disorder
 Evidence X-RAY 6k4q B Reference
       Region 6k4q B 1-2 disorder
       Region 6k4q B 3-714 order
       Region 6k4q B 715-718 disorder
       Region 6k4q B 719-765 order
       Region 6k4q B 766-773 disorder
       Region 6k4q B 774-1011 order
       Region 6k4q B 1012-1029 disorder
       Region 6k4q B 1030-1050 order
       Region 6k4q B 1051-1058 disorder
       Region 6k4q B 1059-1244 order
       Region 6k4q B 1245-1248 disorder
       Region 6k4q B 1249-1367 order
       Region 6k4q B 1368-1368 disorder
 Evidence X-RAY 6k4s B Reference
       Region 6k4s B 1-2 disorder
       Region 6k4s B 3-178 order
       Region 6k4s B 179-180 disorder
       Region 6k4s B 181-712 order
       Region 6k4s B 713-718 disorder
       Region 6k4s B 719-765 order
       Region 6k4s B 766-776 disorder
       Region 6k4s B 777-816 order
       Region 6k4s B 817-818 disorder
       Region 6k4s B 819-1012 order
       Region 6k4s B 1013-1029 disorder
       Region 6k4s B 1030-1051 order
       Region 6k4s B 1052-1058 disorder
       Region 6k4s B 1059-1241 order
       Region 6k4s B 1242-1251 disorder
       Region 6k4s B 1252-1365 order
       Region 6k4s B 1366-1368 disorder
 Evidence X-RAY 6k4u B Reference
       Region 6k4u B 1-178 order
       Region 6k4u B 179-180 disorder
       Region 6k4u B 181-712 order
       Region 6k4u B 713-717 disorder
       Region 6k4u B 718-765 order
       Region 6k4u B 766-775 disorder
       Region 6k4u B 776-800 order
       Region 6k4u B 801-802 disorder
       Region 6k4u B 803-1012 order
       Region 6k4u B 1013-1029 disorder
       Region 6k4u B 1030-1051 order
       Region 6k4u B 1052-1058 disorder
       Region 6k4u B 1059-1241 order
       Region 6k4u B 1242-1251 disorder
       Region 6k4u B 1252-1365 order
       Region 6k4u B 1366-1368 disorder
 Evidence X-RAY 6k57 B Reference
       Region 6k57 B 1-3 disorder
       Region 6k57 B 4-383 order
       Region 6k57 B 384-385 disorder
       Region 6k57 B 386-713 order
       Region 6k57 B 714-718 disorder
       Region 6k57 B 719-765 order
       Region 6k57 B 766-775 disorder
       Region 6k57 B 776-1012 order
       Region 6k57 B 1013-1029 disorder
       Region 6k57 B 1030-1050 order
       Region 6k57 B 1051-1058 disorder
       Region 6k57 B 1059-1242 order
       Region 6k57 B 1243-1246 disorder
       Region 6k57 B 1247-1364 order
       Region 6k57 B 1365-1368 disorder
 Evidence X-RAY 7ox7 B Reference
       Region 7ox7 B 1-2 disorder
       Region 7ox7 B 3-713 order
       Region 7ox7 B 714-716 disorder
       Region 7ox7 B 717-765 order
       Region 7ox7 B 766-775 disorder
       Region 7ox7 B 776-905 order
       Region 7ox7 B 906-907 disorder
       Region 7ox7 B 908-1015 order
       Region 7ox7 B 1016-1031 disorder
       Region 7ox7 B 1032-1052 order
       Region 7ox7 B 1053-1054 disorder
       Region 7ox7 B 1055-1242 order
       Region 7ox7 B 1243-1250 disorder
       Region 7ox7 B 1251-1366 order
       Region 7ox7 B 1367-1368 disorder
 Evidence X-RAY 7ox8 B Reference
       Region 7ox8 B 1-2 disorder
       Region 7ox8 B 3-714 order
       Region 7ox8 B 715-715 disorder
       Region 7ox8 B 716-766 order
       Region 7ox8 B 767-775 disorder
       Region 7ox8 B 776-1012 order
       Region 7ox8 B 1013-1030 disorder
       Region 7ox8 B 1031-1052 order
       Region 7ox8 B 1053-1056 disorder
       Region 7ox8 B 1057-1243 order
       Region 7ox8 B 1244-1245 disorder
       Region 7ox8 B 1246-1366 order
       Region 7ox8 B 1367-1368 disorder
 Evidence X-RAY 7ox9 B Reference
       Region 7ox9 B 1-2 disorder
       Region 7ox9 B 3-767 order
       Region 7ox9 B 768-774 disorder
       Region 7ox9 B 775-1012 order
       Region 7ox9 B 1013-1030 disorder
       Region 7ox9 B 1031-1052 order
       Region 7ox9 B 1053-1054 disorder
       Region 7ox9 B 1055-1367 order
       Region 7ox9 B 1368-1368 disorder
 Evidence X-RAY 7oxa B Reference
       Region 7oxa B 1-2 disorder
       Region 7oxa B 3-713 order
       Region 7oxa B 714-716 disorder
       Region 7oxa B 717-765 order
       Region 7oxa B 766-775 disorder
       Region 7oxa B 776-791 order
       Region 7oxa B 792-792 disorder
       Region 7oxa B 793-800 order
       Region 7oxa B 801-802 disorder
       Region 7oxa B 803-905 order
       Region 7oxa B 906-907 disorder
       Region 7oxa B 908-1014 order
       Region 7oxa B 1015-1031 disorder
       Region 7oxa B 1032-1052 order
       Region 7oxa B 1053-1054 disorder
       Region 7oxa B 1055-1242 order
       Region 7oxa B 1243-1250 disorder
       Region 7oxa B 1251-1367 order
       Region 7oxa B 1368-1368 disorder
 Evidence X-RAY 7qqo B Reference
       Region 7qqo B 1-2 disorder
       Region 7qqo B 3-267 order
       Region 7qqo B 268-269 disorder
       Region 7qqo B 270-766 order
       Region 7qqo B 767-774 disorder
       Region 7qqo B 775-905 order
       Region 7qqo B 906-907 disorder
       Region 7qqo B 908-1012 order
       Region 7qqo B 1013-1030 disorder
       Region 7qqo B 1031-1053 order
       Region 7qqo B 1054-1056 disorder
       Region 7qqo B 1057-1242 order
       Region 7qqo B 1243-1246 disorder
       Region 7qqo B 1247-1367 order
       Region 7qqo B 1368-1368 disorder
 Evidence X-RAY 7qqp B Reference
       Region 7qqp B 1-2 disorder
       Region 7qqp B 3-766 order
       Region 7qqp B 767-774 disorder
       Region 7qqp B 775-1012 order
       Region 7qqp B 1013-1030 disorder
       Region 7qqp B 1031-1053 order
       Region 7qqp B 1054-1055 disorder
       Region 7qqp B 1056-1243 order
       Region 7qqp B 1244-1245 disorder
       Region 7qqp B 1246-1366 order
       Region 7qqp B 1367-1368 disorder
 Evidence X-RAY 7qqq B Reference
       Region 7qqq B 1-2 disorder
       Region 7qqq B 3-715 order
       Region 7qqq B 716-716 disorder
       Region 7qqq B 717-766 order
       Region 7qqq B 767-774 disorder
       Region 7qqq B 775-1012 order
       Region 7qqq B 1013-1030 disorder
       Region 7qqq B 1031-1053 order
       Region 7qqq B 1054-1055 disorder
       Region 7qqq B 1056-1367 order
       Region 7qqq B 1368-1368 disorder
 Evidence X-RAY 7qqr B Reference
       Region 7qqr B 1-2 disorder
       Region 7qqr B 3-766 order
       Region 7qqr B 767-774 disorder
       Region 7qqr B 775-1012 order
       Region 7qqr B 1013-1030 disorder
       Region 7qqr B 1031-1052 order
       Region 7qqr B 1053-1055 disorder
       Region 7qqr B 1056-1243 order
       Region 7qqr B 1244-1244 disorder
       Region 7qqr B 1245-1366 order
       Region 7qqr B 1367-1368 disorder
 Evidence X-RAY 7qqs B Reference
       Region 7qqs B 1-2 disorder
       Region 7qqs B 3-765 order
       Region 7qqs B 766-774 disorder
       Region 7qqs B 775-1012 order
       Region 7qqs B 1013-1030 disorder
       Region 7qqs B 1031-1051 order
       Region 7qqs B 1052-1056 disorder
       Region 7qqs B 1057-1367 order
       Region 7qqs B 1368-1368 disorder
 Evidence X-RAY 7qqt B Reference
       Region 7qqt B 1-1 disorder
       Region 7qqt B 2-767 order
       Region 7qqt B 768-774 disorder
       Region 7qqt B 775-1012 order
       Region 7qqt B 1013-1030 disorder
       Region 7qqt B 1031-1052 order
       Region 7qqt B 1053-1058 disorder
       Region 7qqt B 1059-1243 order
       Region 7qqt B 1244-1245 disorder
       Region 7qqt B 1246-1367 order
       Region 7qqt B 1368-1368 disorder
 Evidence X-RAY 7qqu B Reference
       Region 7qqu B 1-2 disorder
       Region 7qqu B 3-713 order
       Region 7qqu B 714-715 disorder
       Region 7qqu B 716-765 order
       Region 7qqu B 766-774 disorder
       Region 7qqu B 775-1012 order
       Region 7qqu B 1013-1030 disorder
       Region 7qqu B 1031-1051 order
       Region 7qqu B 1052-1058 disorder
       Region 7qqu B 1059-1243 order
       Region 7qqu B 1244-1245 disorder
       Region 7qqu B 1246-1367 order
       Region 7qqu B 1368-1368 disorder
 Evidence X-RAY 7qqv B Reference
       Region 7qqv B 1-2 disorder
       Region 7qqv B 3-766 order
       Region 7qqv B 767-774 disorder
       Region 7qqv B 775-1012 order
       Region 7qqv B 1013-1030 disorder
       Region 7qqv B 1031-1051 order
       Region 7qqv B 1052-1058 disorder
       Region 7qqv B 1059-1366 order
       Region 7qqv B 1367-1368 disorder
 Evidence X-RAY 7qqw B Reference
       Region 7qqw B 1-2 disorder
       Region 7qqw B 3-257 order
       Region 7qqw B 258-264 disorder
       Region 7qqw B 265-283 order
       Region 7qqw B 284-285 disorder
       Region 7qqw B 286-306 order
       Region 7qqw B 307-309 disorder
       Region 7qqw B 310-766 order
       Region 7qqw B 767-774 disorder
       Region 7qqw B 775-1013 order
       Region 7qqw B 1014-1030 disorder
       Region 7qqw B 1031-1049 order
       Region 7qqw B 1050-1058 disorder
       Region 7qqw B 1059-1245 order
       Region 7qqw B 1246-1247 disorder
       Region 7qqw B 1248-1367 order
       Region 7qqw B 1368-1368 disorder
 Evidence X-RAY 7qqx B Reference
       Region 7qqx B 1-2 disorder
       Region 7qqx B 3-766 order
       Region 7qqx B 767-774 disorder
       Region 7qqx B 775-1012 order
       Region 7qqx B 1013-1030 disorder
       Region 7qqx B 1031-1053 order
       Region 7qqx B 1054-1055 disorder
       Region 7qqx B 1056-1366 order
       Region 7qqx B 1367-1368 disorder
 Evidence X-RAY 7qqz B Reference
       Region 7qqz B 1-2 disorder
       Region 7qqz B 3-768 order
       Region 7qqz B 769-774 disorder
       Region 7qqz B 775-1012 order
       Region 7qqz B 1013-1030 disorder
       Region 7qqz B 1031-1051 order
       Region 7qqz B 1052-1054 disorder
       Region 7qqz B 1055-1243 order
       Region 7qqz B 1244-1245 disorder
       Region 7qqz B 1246-1366 order
       Region 7qqz B 1367-1368 disorder
 Evidence X-RAY 7qr0 B Reference
       Region 7qr0 B 1-1 disorder
       Region 7qr0 B 2-766 order
       Region 7qr0 B 767-774 disorder
       Region 7qr0 B 775-1012 order
       Region 7qr0 B 1013-1030 disorder
       Region 7qr0 B 1031-1052 order
       Region 7qr0 B 1053-1056 disorder
       Region 7qr0 B 1057-1242 order
       Region 7qr0 B 1243-1245 disorder
       Region 7qr0 B 1246-1367 order
       Region 7qr0 B 1368-1368 disorder
 Evidence X-RAY 7qr1 B Reference
       Region 7qr1 B 1-2 disorder
       Region 7qr1 B 3-713 order
       Region 7qr1 B 714-716 disorder
       Region 7qr1 B 717-765 order
       Region 7qr1 B 766-774 disorder
       Region 7qr1 B 775-1012 order
       Region 7qr1 B 1013-1030 disorder
       Region 7qr1 B 1031-1051 order
       Region 7qr1 B 1052-1056 disorder
       Region 7qr1 B 1057-1243 order
       Region 7qr1 B 1244-1245 disorder
       Region 7qr1 B 1246-1367 order
       Region 7qr1 B 1368-1368 disorder
 Evidence X-RAY 7qr5 B Reference
       Region 7qr5 B 1-2 disorder
       Region 7qr5 B 3-766 order
       Region 7qr5 B 767-774 disorder
       Region 7qr5 B 775-1012 order
       Region 7qr5 B 1013-1030 disorder
       Region 7qr5 B 1031-1052 order
       Region 7qr5 B 1053-1055 disorder
       Region 7qr5 B 1056-1243 order
       Region 7qr5 B 1244-1245 disorder
       Region 7qr5 B 1246-1366 order
       Region 7qr5 B 1367-1368 disorder
 Evidence X-RAY 7qr7 B Reference
       Region 7qr7 B 1-2 disorder
       Region 7qr7 B 3-267 order
       Region 7qr7 B 268-269 disorder
       Region 7qr7 B 270-713 order
       Region 7qr7 B 714-716 disorder
       Region 7qr7 B 717-766 order
       Region 7qr7 B 767-775 disorder
       Region 7qr7 B 776-1012 order
       Region 7qr7 B 1013-1030 disorder
       Region 7qr7 B 1031-1053 order
       Region 7qr7 B 1054-1055 disorder
       Region 7qr7 B 1056-1242 order
       Region 7qr7 B 1243-1246 disorder
       Region 7qr7 B 1247-1366 order
       Region 7qr7 B 1367-1368 disorder
 Evidence X-RAY 7qr8 B Reference
       Region 7qr8 B 1-2 disorder
       Region 7qr8 B 3-766 order
       Region 7qr8 B 767-775 disorder
       Region 7qr8 B 776-1012 order
       Region 7qr8 B 1013-1031 disorder
       Region 7qr8 B 1032-1051 order
       Region 7qr8 B 1052-1056 disorder
       Region 7qr8 B 1057-1367 order
       Region 7qr8 B 1368-1368 disorder
 Evidence X-RAY 7vk9 A Reference
       Region 7vk9 A 1-1 disorder
       Region 7vk9 A 2-108 order
       Region 7vk9 A 109-115 disorder
       Region 7vk9 A 116-457 order
       Region 7vk9 A 458-496 disorder
       Region 7vk9 A 497-1103 order
       Region 7vk9 A 1104-1135 disorder
       Region 7vk9 A 1136-1149 order
       Region 7vk9 A 1150-1156 disorder
       Region 7vk9 A 1157-1365 order
       Region 7vk9 A 1366-1368 disorder
 Evidence X-RAY 7zo1 B Reference
       Region 7zo1 B 1-2 disorder
       Region 7zo1 B 3-712 order
       Region 7zo1 B 713-717 disorder
       Region 7zo1 B 718-765 order
       Region 7zo1 B 766-922 disorder
       Region 7zo1 B 923-1011 order
       Region 7zo1 B 1012-1037 disorder
       Region 7zo1 B 1038-1051 order
       Region 7zo1 B 1052-1054 disorder
       Region 7zo1 B 1055-1243 order
       Region 7zo1 B 1244-1247 disorder
       Region 7zo1 B 1248-1366 order
       Region 7zo1 B 1367-1368 disorder
Seq 1-1368 Hetero dimer : A0A247D711
 Evidence X-RAY 5xbl A Reference
       Region 5xbl A 1-2 disorder
       Region 5xbl A 3-230 order
       Region 5xbl A 231-231 disorder
       Region 5xbl A 232-308 order
       Region 5xbl A 309-311 disorder
       Region 5xbl A 312-529 order
       Region 5xbl A 530-539 disorder
       Region 5xbl A 540-576 order
       Region 5xbl A 577-586 disorder
       Region 5xbl A 587-673 order
       Region 5xbl A 674-674 disorder
       Region 5xbl A 675-694 order
       Region 5xbl A 695-705 disorder
       Region 5xbl A 706-711 order
       Region 5xbl A 712-716 disorder
       Region 5xbl A 717-769 order
       Region 5xbl A 770-772 disorder
       Region 5xbl A 773-1366 order
       Region 5xbl A 1367-1368 disorder
Seq 775-908 Homo dimer :
 Evidence X-RAY 6o56 B Reference
       Region 6o56 B 775-908 order
 Evidence X-RAY 6o56 A Reference
       Region 6o56 A 775-908 order
SeqProS verified 448-501,1103-1136 PAM-binding loop 1 and 2 (PMID: 24505130); Only representative PDB datasets are shown as ProS evidence. Hetero dimer : A0A0E0UT28
       Region 5vw1 A 1-714 order
       Region 5vw1 A 1033-1368 order
       Region 4cmp B 448-501 disorder
       Region 4cmp B 1103-1136 disorder
SeqProS verified 448-501,1103-1136 PAM-binding loop 1 and 2 (PMID: 24505130); Only representative PDB datasets are shown as ProS evidence. :
       Region 5f9r B 3-1364 order
       Region 4zt0 A 3-1366 order
       Region 4zt0 C 4-766 order
       Region 4oo8 A 314-713 order
       Region 4oo8 D 3-713 order
       Region 4un3 B 386-710 order
       Region 4zt0 C 1057-1366 order
       Region 4oo8 A 1063-1242 order
       Region 4oo8 D 1062-1243 order
       Region 4un3 B 1059-1241 order
       Region 4cmp B 448-501 disorder
       Region 4cmp B 1103-1136 disorder
SeqProS verified 448-501,1103-1136 PAM-binding loop 1 and 2 (PMID: 24505130); Only representative PDB datasets are shown as ProS evidence. Hetero dimer : A0A247D711
       Region 5xbl A 312-529 order
       Region 5xbl A 773-1366 order
       Region 4cmp B 448-501 disorder
       Region 4cmp B 1103-1136 disorder
SeqProS verified 448-501,1103-1136 PAM-binding loop 1 and 2 (PMID: 24505130); Only representative PDB datasets are shown as ProS evidence. Hetero tetramer :
       Region 6ifo A 1-714 order
       Region 6ifo B 1-714 order
       Region 6ifo A 1033-1368 order
       Region 6ifo B 1033-1368 order
       Region 4cmp B 448-501 disorder
       Region 4cmp B 1103-1136 disorder
 
Prediction
NeProc
Disorder 67-77,895-907
Order 1-66,78-894,908-1368
ProS 67-77,895-907
AlphaFold
Disorder 1-3,175-179,215-215,713-718,729-729,765-776,848-849,861-868,924-924,1012-1034,1246-1249,1367-1368
Order 4-174,180-214,216-712,719-728,730-764,777-847,850-860,869-923,925-1011,1035-1245,1250-1366
SEG 58-78 ,605-619 ,1148-1165
Function
Function in SwissProt
CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids) (PubMed:21455174). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA; Cas9 only stabilizes the pre-crRNA:tracrRNA interaction and has no catalytic function in RNA processing (PubMed:24270795). Subsequently Cas9/crRNA/tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer; Cas9 is inactive in the absence of the 2 guide RNAs (gRNA). The target strand not complementary to crRNA is first cut endonucleolytically, then trimmed 3'-5' exonucleolytically. DNA-binding requires protein and both gRNAs, as does nuclease activity. Cas9 recognizes the protospacer adjacent motif (PAM) in the CRISPR repeat sequences to help distinguish self versus nonself, as targets within the bacterial CRISPR locus do not have PAMs. DNA strand separation and heteroduplex formation starts at PAM sites; PAM recognition is required for catalytic activity (PubMed:24476820). Confers immunity against a plasmid with homology to the appropriate CRISPR spacer sequences (CRISPR interference) (PubMed:21455174).
Biological Process
Diagram with PDB data
cas9/RNA/DNACrystal structure of catalytically-active Streptococcus pyogenes CRISPR-Cas9 in complex with single-guided RNA and double-stranded DNA primed for target DNA cleavage
cas9/RNA/acrIIA4Crystal structure of SpyCas9-sgRNA-AcrIIA4 ternary complex