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IID00293
 UniprotP04626
ProteinReceptor tyrosine-protein kinase erbB-2
GeneERBB2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1255
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 22-530 Monomer :
 Evidence X-RAY 2a91 A Reference
       Region 2a91 A 22-123 order
       Region 2a91 A 124-127 disorder
       Region 2a91 A 128-530 order
Seq 23-214 Hetero dimer :
 Evidence X-RAY 3h3b B Reference
       Region 3h3b B 23-199 order
       Region 3h3b B 200-202 disorder
       Region 3h3b B 203-213 order
       Region 3h3b B 214-214 disorder
Seq 23-214 Hetero dimer :
 Evidence X-RAY 3h3b A Reference
       Region 3h3b A 23-214 order
Seq 23-586 Hetero trimer :
 Evidence X-RAY 3wlw A Reference
       Region 3wlw A 23-123 order
       Region 3wlw A 124-132 disorder
       Region 3wlw A 133-586 order
Seq 23-586 Hetero trimer :
 Evidence X-RAY 3wlw B Reference
       Region 3wlw B 23-123 order
       Region 3wlw B 124-132 disorder
       Region 3wlw B 133-586 order
Seq 23-586 Hetero trimer :
 Evidence X-RAY 3wsq A Reference
       Region 3wsq A 23-123 order
       Region 3wsq A 124-132 disorder
       Region 3wsq A 133-586 order
Seq 23-629 Hetero trimer :
 Evidence X-RAY 1n8z C Reference
       Region 1n8z C 23-123 order
       Region 1n8z C 124-132 disorder
       Region 1n8z C 133-324 order
       Region 1n8z C 325-327 disorder
       Region 1n8z C 328-382 order
       Region 1n8z C 383-386 disorder
       Region 1n8z C 387-602 order
       Region 1n8z C 603-612 disorder
       Region 1n8z C 613-629 order
Seq 23-646 Hetero trimer : Q7Z3Y4
 Evidence X-RAY 1s78 B Reference
       Region 1s78 B 23-123 order
       Region 1s78 B 124-132 disorder
       Region 1s78 B 133-599 order
       Region 1s78 B 600-646 disorder
Seq 23-646 Hetero trimer : P01834,P01857
 Evidence X-RAY 3be1 A Reference
       Region 3be1 A 23-122 order
       Region 3be1 A 123-132 disorder
       Region 3be1 A 133-383 order
       Region 3be1 A 384-387 disorder
       Region 3be1 A 388-602 order
       Region 3be1 A 603-612 disorder
       Region 3be1 A 613-629 order
       Region 3be1 A 630-646 disorder
Seq 23-646 Hetero trimer : Q7Z3Y4
 Evidence X-RAY 1s78 A Reference
       Region 1s78 A 23-123 order
       Region 1s78 A 124-132 disorder
       Region 1s78 A 133-586 order
       Region 1s78 A 587-646 disorder
Seq 23-646 Hetero nonamer :
 Evidence X-RAY 3n85 A Reference
       Region 3n85 A 23-122 order
       Region 3n85 A 123-132 disorder
       Region 3n85 A 133-269 order
       Region 3n85 A 270-274 disorder
       Region 3n85 A 275-642 order
       Region 3n85 A 643-646 disorder
Seq 23-646 Hetero dimer : P38507
 Evidence X-RAY 3mzw A Reference
       Region 3mzw A 23-123 order
       Region 3mzw A 124-132 disorder
       Region 3mzw A 133-600 order
       Region 3mzw A 601-646 disorder
Seq 23-653 Hetero tetramer : P01857
 Evidence X-RAY 5kwg C Reference
       Region 5kwg C 23-124 order
       Region 5kwg C 125-129 disorder
       Region 5kwg C 130-324 order
       Region 5kwg C 325-327 disorder
       Region 5kwg C 328-385 order
       Region 5kwg C 386-388 disorder
       Region 5kwg C 389-588 order
       Region 5kwg C 589-591 disorder
       Region 5kwg C 592-597 order
       Region 5kwg C 598-653 disorder
 Evidence X-RAY 5k33 C Reference
       Region 5k33 C 23-124 order
       Region 5k33 C 125-129 disorder
       Region 5k33 C 130-324 order
       Region 5k33 C 325-327 disorder
       Region 5k33 C 328-385 order
       Region 5k33 C 386-388 disorder
       Region 5k33 C 389-589 order
       Region 5k33 C 590-591 disorder
       Region 5k33 C 592-598 order
       Region 5k33 C 599-629 disorder
Seq 24-219 Hetero dimer :
 Evidence X-RAY 4hrl C Reference
       Region 4hrl C 24-36 order
       Region 4hrl C 37-38 disorder
       Region 4hrl C 39-39 order
       Region 4hrl C 40-40 disorder
       Region 4hrl C 41-121 order
       Region 4hrl C 122-132 disorder
       Region 4hrl C 133-186 order
       Region 4hrl C 187-191 disorder
       Region 4hrl C 192-199 order
       Region 4hrl C 200-201 disorder
       Region 4hrl C 202-213 order
       Region 4hrl C 214-219 disorder
Seq 24-219 Hetero tetramer :
 Evidence X-RAY 4hrm C Reference
       Region 4hrm C 24-26 order
       Region 4hrm C 27-27 disorder
       Region 4hrm C 28-120 order
       Region 4hrm C 121-134 disorder
       Region 4hrm C 135-184 order
       Region 4hrm C 185-186 disorder
       Region 4hrm C 187-187 order
       Region 4hrm C 188-191 disorder
       Region 4hrm C 192-199 order
       Region 4hrm C 200-201 disorder
       Region 4hrm C 202-209 order
       Region 4hrm C 210-210 disorder
       Region 4hrm C 211-213 order
       Region 4hrm C 214-219 disorder
 Evidence X-RAY 4hrm A Reference
       Region 4hrm A 24-27 disorder
       Region 4hrm A 28-36 order
       Region 4hrm A 37-37 disorder
       Region 4hrm A 38-54 order
       Region 4hrm A 55-55 disorder
       Region 4hrm A 56-56 order
       Region 4hrm A 57-57 disorder
       Region 4hrm A 58-66 order
       Region 4hrm A 67-68 disorder
       Region 4hrm A 69-73 order
       Region 4hrm A 74-74 disorder
       Region 4hrm A 75-111 order
       Region 4hrm A 112-112 disorder
       Region 4hrm A 113-119 order
       Region 4hrm A 120-134 disorder
       Region 4hrm A 135-148 order
       Region 4hrm A 149-149 disorder
       Region 4hrm A 150-173 order
       Region 4hrm A 174-176 disorder
       Region 4hrm A 177-184 order
       Region 4hrm A 185-186 disorder
       Region 4hrm A 187-189 order
       Region 4hrm A 190-191 disorder
       Region 4hrm A 192-194 order
       Region 4hrm A 195-202 disorder
       Region 4hrm A 203-204 order
       Region 4hrm A 205-219 disorder
Seq 24-645 Hetero dimer :
 Evidence X-RAY 5my6 A Reference
       Region 5my6 A 24-122 order
       Region 5my6 A 123-131 disorder
       Region 5my6 A 132-334 order
       Region 5my6 A 335-336 disorder
       Region 5my6 A 337-587 order
       Region 5my6 A 588-594 disorder
       Region 5my6 A 595-597 order
       Region 5my6 A 598-645 disorder
Seq 529-625 Hetero dimer :
 Evidence X-RAY 4hrn C This region binds to a peptide. Reference
       Region 4hrn C 529-530 disorder
       Region 4hrn C 531-601 order
       Region 4hrn C 602-625 disorder
Seq 529-625 Hetero dimer :
 Evidence X-RAY 4hrn D This region binds to a peptide. Reference
       Region 4hrn D 529-530 disorder
       Region 4hrn D 531-600 order
       Region 4hrn D 601-625 disorder
Seq 641-684 Homo dimer :
 Evidence NMR 2jwa B Reference
       Region 2jwa B 641-684 order
       Region 2jwa B 641-647 high_rmsd
       Region 2jwa B 680-684 high_rmsd
 Evidence NMR 2jwa A Reference
       Region 2jwa A 641-684 order
       Region 2jwa A 641-647 high_rmsd
       Region 2jwa A 681-684 high_rmsd
 Evidence NMR 5ob4 B Reference
       Region 5ob4 B 641-684 order
       Region 5ob4 B 641-645 high_rmsd
       Region 5ob4 B 680-684 high_rmsd
 Evidence NMR 5ob4 A Reference
       Region 5ob4 A 641-684 order
       Region 5ob4 A 641-646 high_rmsd
       Region 5ob4 A 680-684 high_rmsd
Seq 641-684 Hetero dimer : IID00262Complex
 Evidence NMR 2ks1 A Reference
       Region 2ks1 A 641-684 order
       Region 2ks1 A 641-646 high_rmsd
       Region 2ks1 A 679-684 high_rmsd
Seq 644-700 Homo dimer :
 Evidence NMR 2n2a B Reference
       Region 2n2a B 644-700 order
 Evidence NMR 2n2a A Reference
       Region 2n2a A 644-700 order
Seq 654-662 Hetero trimer : P01892
 Evidence X-RAY 1qr1 F Reference
       Region 1qr1 F 654-662 order
 Evidence X-RAY 1qr1 C Reference
       Region 1qr1 C 654-662 order
Seq 703-1029 Monomer :
 Evidence X-RAY 3rcd D Reference
       Region 3rcd D 713-756 order
       Region 3rcd D 757-760 disorder
       Region 3rcd D 761-865 order
       Region 3rcd D 866-883 disorder
       Region 3rcd D 884-991 order
       Region 3rcd D 992-999 disorder
       Region 3rcd D 1000-1010 order
       Region 3rcd D 1011-1028 disorder
 Evidence X-RAY 3rcd C Reference
       Region 3rcd C 713-756 order
       Region 3rcd C 757-760 disorder
       Region 3rcd C 761-866 order
       Region 3rcd C 867-883 disorder
       Region 3rcd C 884-991 order
       Region 3rcd C 992-999 disorder
       Region 3rcd C 1000-1012 order
       Region 3rcd C 1013-1015 disorder
       Region 3rcd C 1016-1022 order
       Region 3rcd C 1023-1028 disorder
 Evidence X-RAY 3rcd B Reference
       Region 3rcd B 713-756 order
       Region 3rcd B 757-760 disorder
       Region 3rcd B 761-865 order
       Region 3rcd B 866-883 disorder
       Region 3rcd B 884-991 order
       Region 3rcd B 992-999 disorder
       Region 3rcd B 1000-1010 order
       Region 3rcd B 1011-1028 disorder
 Evidence X-RAY 3rcd A Reference
       Region 3rcd A 713-756 order
       Region 3rcd A 757-760 disorder
       Region 3rcd A 761-866 order
       Region 3rcd A 867-883 disorder
       Region 3rcd A 884-991 order
       Region 3rcd A 992-999 disorder
       Region 3rcd A 1000-1012 order
       Region 3rcd A 1013-1015 disorder
       Region 3rcd A 1016-1022 order
       Region 3rcd A 1023-1028 disorder
 Evidence X-RAY 3pp0 B Reference
       Region 3pp0 B 703-705 disorder
       Region 3pp0 B 706-879 order
       Region 3pp0 B 880-881 disorder
       Region 3pp0 B 882-992 order
       Region 3pp0 B 993-998 disorder
       Region 3pp0 B 999-1009 order
       Region 3pp0 B 1010-1029 disorder
 Evidence X-RAY 3pp0 A Reference
       Region 3pp0 A 703-705 disorder
       Region 3pp0 A 706-879 order
       Region 3pp0 A 880-881 disorder
       Region 3pp0 A 882-993 order
       Region 3pp0 A 994-1029 disorder
Seq 1135-1144 Hetero dimer : IID00566Complex
 Evidence NMR 1mw4 B Reference
       Region 1mw4 B 1135-1144 order
 Evidence NMR 2l4k B Reference
       Region 2l4k B 1135-1144 order
Seq 1218-1228 Hetero dimer : P08487
 Evidence X-RAY 5tqs H Reference
       Region 5tqs H 1218-1224 order
       Region 5tqs H 1225-1228 disorder
 Evidence X-RAY 5tqs G Reference
       Region 5tqs G 1218-1225 order
       Region 5tqs G 1226-1228 disorder
 Evidence X-RAY 5tqs F Reference
       Region 5tqs F 1218-1218 disorder
       Region 5tqs F 1219-1225 order
       Region 5tqs F 1226-1228 disorder
 Evidence X-RAY 5tqs E Reference
       Region 5tqs E 1218-1219 disorder
       Region 5tqs E 1220-1225 order
       Region 5tqs E 1226-1228 disorder
Seq 1246-1252 Hetero dimer : IID00581Complex
 Evidence X-RAY 4gfu F Reference
       Region 4gfu F 1246-1252 order
Seq 1247-1255 Hetero dimer : IID00494Complex
 Evidence X-RAY 1mfl B Reference
       Region 1mfl B 1247-1250 disorder
       Region 1mfl B 1251-1255 order
 Evidence X-RAY 1mfg B Reference
       Region 1mfg B 1247-1255 order
SeqProS verified 1247-1250,1251-1255 This region may be disordered in the free state same as phosphorylated form(1mfl). Hetero dimer : IID00494Complex
       Region 1mfg B 1247-1255 order
       Region 1mfl B 1251-1255 order
       Region 1mfl B 1247-1250 disorder
Seqphosphorylation
    1248-1248 Phosphotyrosine; by autocatalysis
    1196-1196 Phosphotyrosine
    1166-1166 Phosphothreonine
    1151-1151 Phosphoserine
    1139-1139 Phosphotyrosine
    1112-1112 Phosphotyrosine
    1107-1107 Phosphoserine
    1083-1083 Phosphoserine
    1078-1078 Phosphoserine
    1054-1054 Phosphoserine
    877-877 Phosphotyrosine
    182-182 Phosphothreonine
 
Prediction
NeProc
Disorder 1-17,640-652,676-690,997-1212
Order 18-639,653-675,691-992,1213-1227,1233-1255
ProS 4-17,640-652,676-690,1001-1010,1016-1033,1040-1063,1085-1144,1151-1199
AlphaFold
Disorder 1-23,122-133,605-611,628-658,680-712,729-731,756-770,864-883,990-1018,1021-1255
Order 24-121,134-604,612-627,659-679,713-728,732-755,771-863,884-989,1019-1020
Pfam Hmmer
PF01030 52-173 2e-43
PF00757 189-343 3.6e-94
PF01030 366-486 6.4e-31
PF07714 720-976 2.3e-133
SEG 3-21 ,453-467 ,658-675 ,1044-1063 ,1199-1217
Function
Function in SwissProt
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.
In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.
Biological Process
Diagram with PDB data
ERBB2/PTPN18PTPN18 in complex with HER2-pY1248 phosphor-peptides
ERBB2/ERBINThe Structure of ERBIN PDZ domain bound to the Carboxy-terminal tail of the ErbB2 Receptor
ERBB2/PLCG1Phospholipase C gamma-1 C-terminal SH2 domain bound to a phosphopeptide derived from the receptor tyrosine kinase ErbB2
ERBB2/GRB7Water refined solution structure of the human Grb7-SH2 domain in complex with the 10 amino acid peptide pY1139
ERBB2/PTPN18Structural basis of PTPN18 fingerprint on distinct HER2 tyrosine phosphorylation sites