IID00581
UniprotQ99952
ProteinTyrosine-protein phosphatase non-receptor type 18
GenePTPN18
OrganismHomo sapiens
Sequence
LLPS
Network
xml
rdf
Structure
Experiment
:order disorder conflict PDB cluster ProS Pfam Domain SEG
460
order/disorder by at least rule
disorder by at least rule
order/disorder by majority rule
Seq 6-295 Hetero octamer :
Region 4nnd A 19-23 disorder
Region 4nnd A 24-251 order
Region 4nnd A 252-252 disorder
Region 4nnd A 253-294 order
Region 4nnd A 295-295 disorder
Region 4nnd B 19-24 disorder
Region 4nnd B 25-294 order
Region 4nnd B 295-295 disorder
Region 4nnd D 18-24 disorder
Region 4nnd D 25-81 order
Region 4nnd D 82-82 disorder
Region 4nnd D 83-294 order
Region 4nnd D 295-295 disorder
Region 4nnd G 16-24 disorder
Region 4nnd G 25-81 order
Region 4nnd G 82-82 disorder
Region 4nnd G 83-201 order
Region 4nnd G 202-202 disorder
Region 4nnd G 203-294 order
Region 4nnd G 295-295 disorder
Region 2oc3 A 9-9 disorder
Region 2oc3 A 10-15 order
Region 2oc3 A 16-23 disorder
Region 2oc3 A 24-293 order
Region 2oc3 A 294-299 disorder
Region 4gfv A 6-201 order
Region 4gfv A 202-203 disorder
Region 4gfv A 204-293 order
Region 4gfv A 294-300 disorder
Region 4gfv B 6-6 disorder
Region 4gfv B 7-201 order
Region 4gfv B 202-202 disorder
Region 4gfv B 203-295 order
Region 4gfv B 296-300 disorder
Seq 6-300 Hetero dimer : IID00293Complex
Region 4gfu A 6-24 disorder
Region 4gfu A 25-44 order
Region 4gfu A 45-45 disorder
Region 4gfu A 46-293 order
Region 4gfu A 294-300 disorder
Prediction
Disorder 1-6,304-457,459-460
ProS 1-6,304-328,375-381,386-393,422-457,459-460
Disorder 1-1,19-19,301-452,454-460
Order 2-18,20-300,453-453
Function
Function in SwissProt
Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues.
Biological Process
| See also |
| Diagram with PDB data |
| ERBB2/PTPN18 | PTPN18 in complex with HER2-pY1248 phosphor-peptides |
| ERBB2/PTPN18 | Structural basis of PTPN18 fingerprint on distinct HER2 tyrosine phosphorylation sites |
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