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IID00581
 UniprotQ99952
ProteinTyrosine-protein phosphatase non-receptor type 18
GenePTPN18
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
460
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 6-295 Hetero octamer :
 Evidence X-RAY 4nnd A Reference
       Region 4nnd A 6-18 order
       Region 4nnd A 19-23 disorder
       Region 4nnd A 24-251 order
       Region 4nnd A 252-252 disorder
       Region 4nnd A 253-294 order
       Region 4nnd A 295-295 disorder
 Evidence X-RAY 4nnd B Reference
       Region 4nnd B 6-18 order
       Region 4nnd B 19-24 disorder
       Region 4nnd B 25-294 order
       Region 4nnd B 295-295 disorder
 Evidence X-RAY 4nnd D Reference
       Region 4nnd D 6-17 order
       Region 4nnd D 18-24 disorder
       Region 4nnd D 25-81 order
       Region 4nnd D 82-82 disorder
       Region 4nnd D 83-294 order
       Region 4nnd D 295-295 disorder
 Evidence X-RAY 4nnd G Reference
       Region 4nnd G 6-15 order
       Region 4nnd G 16-24 disorder
       Region 4nnd G 25-81 order
       Region 4nnd G 82-82 disorder
       Region 4nnd G 83-201 order
       Region 4nnd G 202-202 disorder
       Region 4nnd G 203-294 order
       Region 4nnd G 295-295 disorder
Seq 6-299 Monomer :
 Evidence X-RAY 2oc3 A Reference
       Region 2oc3 A 6-8 order
       Region 2oc3 A 9-9 disorder
       Region 2oc3 A 10-15 order
       Region 2oc3 A 16-23 disorder
       Region 2oc3 A 24-293 order
       Region 2oc3 A 294-299 disorder
Seq 6-300 Hetero dimer :
 Evidence X-RAY 4gfv A Reference
       Region 4gfv A 6-201 order
       Region 4gfv A 202-203 disorder
       Region 4gfv A 204-293 order
       Region 4gfv A 294-300 disorder
Seq 6-300 Hetero dimer :
 Evidence X-RAY 4gfv B Reference
       Region 4gfv B 6-6 disorder
       Region 4gfv B 7-201 order
       Region 4gfv B 202-202 disorder
       Region 4gfv B 203-295 order
       Region 4gfv B 296-300 disorder
Seq 6-300 Hetero dimer : IID00293Complex
 Evidence X-RAY 4gfu A Reference
       Region 4gfu A 6-24 disorder
       Region 4gfu A 25-44 order
       Region 4gfu A 45-45 disorder
       Region 4gfu A 46-293 order
       Region 4gfu A 294-300 disorder
Seqphosphorylation
    426-426 Phosphotyrosine
    393-393 Phosphothreonine
    389-389 Phosphotyrosine
 
Prediction
NeProc
Disorder 1-6,304-457,459-460
Order 7-295,458-458
ProS 1-6,304-328,375-381,386-393,422-457,459-460
AlphaFold
Disorder 1-1,19-19,301-452,454-460
Order 2-18,20-300,453-453
Pfam Hmmer
PF00102 56-290 9.6e-111
SEG 361-383
Function
Function in SwissProt
Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues.
Biological Process
See also
Diagram with PDB data
ERBB2/PTPN18PTPN18 in complex with HER2-pY1248 phosphor-peptides
ERBB2/PTPN18Structural basis of PTPN18 fingerprint on distinct HER2 tyrosine phosphorylation sites