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IID00092
 UniprotQ92793
ProteinCREB-binding protein
GeneCREBBP
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
2442
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 58-80 Hetero tetramer : IID00041Complex
 Evidence X-RAY 1rdt E Reference
       Region 1rdt E 58-67 disorder
       Region 1rdt E 68-74 order
       Region 1rdt E 75-80 disorder
Seq 376-402 Monomer :
 Evidence NMR 1wo7 A Reference
       Region 1wo7 A 376-400 order
 Evidence NMR 1wo6 A Reference
       Region 1wo6 A 376-400 order
 Evidence NMR 1liq A Reference
       Region 1liq A 376-402 order
Seq 387-398 Monomer :
 Evidence NMR 1wo5 A Reference
       Region 1wo5 A 387-398 order
 Evidence NMR 1wo4 A Reference
       Region 1wo4 A 387-398 order
 Evidence NMR 1wo3 A Reference
       Region 1wo3 A 387-398 order
Seq 587-673 Hetero trimer : IID00379Complex,IID00442Complex
 Evidence NMR 2lxt A Reference
       Region 2lxt A 587-673 order
       Region 2lxt A 587-591 high_rmsd
       Region 2lxt A 673-673 high_rmsd
Seq 587-673 Hetero dimer : IID00379Complex
 Evidence NMR 2lxs A Reference
       Region 2lxs A 587-673 order
       Region 2lxs A 587-590 high_rmsd
       Region 2lxs A 673-673 high_rmsd
Seq 587-673 Hetero dimer : IID00622Complex
 Evidence NMR 2kwf A Reference
       Region 2kwf A 587-673 order
       Region 2kwf A 587-588 high_rmsd
Seq 1080-1316 Hetero dimer : IID00058Complex
 Evidence X-RAY 4n3w A Reference
       Region 4n3w A 1080-1081 disorder
       Region 4n3w A 1082-1212 order
       Region 4n3w A 1213-1252 disorder
       Region 4n3w A 1253-1261 order
       Region 4n3w A 1262-1268 disorder
       Region 4n3w A 1269-1312 order
       Region 4n3w A 1313-1316 disorder
Seq 1080-1316 Hetero dimer : IID00058Complex
 Evidence X-RAY 4n4f A Reference
       Region 4n4f A 1080-1080 disorder
       Region 4n4f A 1081-1213 order
       Region 4n4f A 1214-1247 disorder
       Region 4n4f A 1248-1261 order
       Region 4n4f A 1262-1268 disorder
       Region 4n4f A 1269-1312 order
       Region 4n4f A 1313-1316 disorder
Seq 1081-1196 Hetero dimer : IID00062Complex
 Evidence X-RAY 5gh9 A Reference
       Region 5gh9 A 1081-1083 disorder
       Region 5gh9 A 1084-1196 order
Seq 1081-1197 Hetero dimer : IID00015Complex
 Evidence NMR 1jsp B Reference
       Region 1jsp B 1081-1197 order
       Region 1jsp B 1120-1120 high_rmsd
Seq 1081-1197 Hetero dimer : IID00058Complex
 Evidence NMR 2rny A Reference
       Region 2rny A 1081-1197 order
Seq 1081-1197 Monomer :
 Evidence X-RAY 5tb6 A Reference
       Region 5tb6 A 1081-1197 order
 Evidence X-RAY 5eng A Reference
       Region 5eng A 1081-1082 disorder
       Region 5eng A 1083-1196 order
       Region 5eng A 1197-1197 disorder
 Evidence NMR 2d82 A Reference
       Region 2d82 A 1081-1197 order
 Evidence X-RAY 4yk0 D Reference
       Region 4yk0 D 1083-1094 disorder
       Region 4yk0 D 1095-1147 order
       Region 4yk0 D 1148-1149 disorder
       Region 4yk0 D 1150-1187 order
       Region 4yk0 D 1188-1196 disorder
 Evidence X-RAY 4yk0 C Reference
       Region 4yk0 C 1083-1088 disorder
       Region 4yk0 C 1089-1147 order
       Region 4yk0 C 1148-1149 disorder
       Region 4yk0 C 1150-1189 order
       Region 4yk0 C 1190-1196 disorder
 Evidence X-RAY 4yk0 B Reference
       Region 4yk0 B 1083-1083 disorder
       Region 4yk0 B 1084-1196 order
 Evidence X-RAY 4yk0 A Reference
       Region 4yk0 A 1083-1083 disorder
       Region 4yk0 A 1084-1196 order
 Evidence X-RAY 4whu A Reference
       Region 4whu A 1081-1197 order
 Evidence X-RAY 5w0q A Reference
       Region 5w0q A 1082-1197 order
 Evidence X-RAY 5w0l B Reference
       Region 5w0l B 1082-1082 disorder
       Region 5w0l B 1083-1196 order
       Region 5w0l B 1197-1197 disorder
 Evidence X-RAY 5w0l A Reference
       Region 5w0l A 1082-1082 disorder
       Region 5w0l A 1083-1196 order
       Region 5w0l A 1197-1197 disorder
 Evidence X-RAY 5w0f A Reference
       Region 5w0f A 1082-1082 disorder
       Region 5w0f A 1083-1196 order
       Region 5w0f A 1197-1197 disorder
 Evidence X-RAY 5w0e A Reference
       Region 5w0e A 1082-1082 disorder
       Region 5w0e A 1083-1196 order
       Region 5w0e A 1197-1197 disorder
 Evidence X-RAY 4ts8 A Reference
       Region 4ts8 A 1081-1084 disorder
       Region 4ts8 A 1085-1196 order
       Region 4ts8 A 1197-1197 disorder
 Evidence X-RAY 4tqn A Reference
       Region 4tqn A 1081-1083 disorder
       Region 4tqn A 1084-1195 order
       Region 4tqn A 1196-1197 disorder
 Evidence X-RAY 3svh B Reference
       Region 3svh B 1081-1197 order
 Evidence X-RAY 3svh A Reference
       Region 3svh A 1081-1197 order
 Evidence X-RAY 3p1f B Reference
       Region 3p1f B 1081-1082 disorder
       Region 3p1f B 1083-1197 order
 Evidence X-RAY 3p1f A Reference
       Region 3p1f A 1081-1197 order
 Evidence X-RAY 3p1e B Reference
       Region 3p1e B 1081-1084 disorder
       Region 3p1e B 1085-1196 order
       Region 3p1e B 1197-1197 disorder
 Evidence X-RAY 3p1e A Reference
       Region 3p1e A 1081-1082 disorder
       Region 3p1e A 1083-1196 order
       Region 3p1e A 1197-1197 disorder
 Evidence X-RAY 3p1d B Reference
       Region 3p1d B 1081-1082 disorder
       Region 3p1d B 1083-1196 order
       Region 3p1d B 1197-1197 disorder
 Evidence X-RAY 3p1d A Reference
       Region 3p1d A 1081-1082 disorder
       Region 3p1d A 1083-1197 order
 Evidence X-RAY 3p1c B Reference
       Region 3p1c B 1081-1084 disorder
       Region 3p1c B 1085-1196 order
       Region 3p1c B 1197-1197 disorder
 Evidence X-RAY 3p1c A Reference
       Region 3p1c A 1081-1082 disorder
       Region 3p1c A 1083-1197 order
 Evidence X-RAY 4ouf B Reference
       Region 4ouf B 1082-1083 disorder
       Region 4ouf B 1084-1195 order
       Region 4ouf B 1196-1197 disorder
 Evidence X-RAY 4ouf A Reference
       Region 4ouf A 1082-1082 disorder
       Region 4ouf A 1083-1196 order
       Region 4ouf A 1197-1197 disorder
 Evidence X-RAY 4nyx A Reference
       Region 4nyx A 1081-1081 disorder
       Region 4nyx A 1082-1197 order
 Evidence X-RAY 4nyw A Reference
       Region 4nyw A 1081-1081 disorder
       Region 4nyw A 1082-1197 order
 Evidence X-RAY 4nyv D Reference
       Region 4nyv D 1081-1082 disorder
       Region 4nyv D 1083-1196 order
       Region 4nyv D 1197-1197 disorder
 Evidence X-RAY 4nyv C Reference
       Region 4nyv C 1081-1082 disorder
       Region 4nyv C 1083-1196 order
       Region 4nyv C 1197-1197 disorder
 Evidence X-RAY 4nyv B Reference
       Region 4nyv B 1081-1081 disorder
       Region 4nyv B 1082-1196 order
       Region 4nyv B 1197-1197 disorder
 Evidence X-RAY 4nyv A Reference
       Region 4nyv A 1081-1196 order
       Region 4nyv A 1197-1197 disorder
 Evidence X-RAY 5nu3 A Reference
       Region 5nu3 A 1081-1197 order
 Evidence X-RAY 5nrw A Reference
       Region 5nrw A 1081-1082 disorder
       Region 5nrw A 1083-1197 order
 Evidence X-RAY 4nr7 A Reference
       Region 4nr7 A 1081-1081 disorder
       Region 4nr7 A 1082-1197 order
 Evidence X-RAY 4nr6 A Reference
       Region 4nr6 A 1081-1081 disorder
       Region 4nr6 A 1082-1197 order
 Evidence X-RAY 4nr5 A Reference
       Region 4nr5 A 1081-1082 disorder
       Region 4nr5 A 1083-1195 order
       Region 4nr5 A 1196-1197 disorder
 Evidence X-RAY 4nr4 B Reference
       Region 4nr4 B 1081-1085 disorder
       Region 4nr4 B 1086-1197 order
 Evidence X-RAY 4nr4 A Reference
       Region 4nr4 A 1081-1084 disorder
       Region 4nr4 A 1085-1197 order
 Evidence X-RAY 5nlk A Reference
       Region 5nlk A 1081-1082 disorder
       Region 5nlk A 1083-1197 order
 Evidence X-RAY 5mqk B Reference
       Region 5mqk B 1081-1082 disorder
       Region 5mqk B 1083-1197 order
 Evidence X-RAY 5mqk A Reference
       Region 5mqk A 1081-1197 order
 Evidence X-RAY 5mqg B Reference
       Region 5mqg B 1081-1083 disorder
       Region 5mqg B 1084-1196 order
       Region 5mqg B 1197-1197 disorder
 Evidence X-RAY 5mqg A Reference
       Region 5mqg A 1081-1081 disorder
       Region 5mqg A 1082-1197 order
 Evidence X-RAY 5mqe B Reference
       Region 5mqe B 1081-1083 disorder
       Region 5mqe B 1084-1195 order
       Region 5mqe B 1196-1197 disorder
 Evidence X-RAY 5mqe A Reference
       Region 5mqe A 1081-1082 disorder
       Region 5mqe A 1083-1196 order
       Region 5mqe A 1197-1197 disorder
 Evidence X-RAY 5mpz A Reference
       Region 5mpz A 1081-1083 disorder
       Region 5mpz A 1084-1193 order
       Region 5mpz A 1194-1197 disorder
 Evidence X-RAY 5mpn A Reference
       Region 5mpn A 1081-1196 order
       Region 5mpn A 1197-1197 disorder
 Evidence X-RAY 5mpk B Reference
       Region 5mpk B 1081-1083 disorder
       Region 5mpk B 1084-1195 order
       Region 5mpk B 1196-1197 disorder
 Evidence X-RAY 5mpk A Reference
       Region 5mpk A 1081-1083 disorder
       Region 5mpk A 1084-1195 order
       Region 5mpk A 1196-1197 disorder
 Evidence X-RAY 5mmg A Reference
       Region 5mmg A 1081-1082 disorder
       Region 5mmg A 1083-1197 order
 Evidence X-RAY 5mme B Reference
       Region 5mme B 1081-1197 order
 Evidence X-RAY 5mme A Reference
       Region 5mme A 1081-1197 order
 Evidence X-RAY 5lpl A Reference
       Region 5lpl A 1081-1197 order
 Evidence X-RAY 5lpj A Reference
       Region 5lpj A 1081-1081 disorder
       Region 5lpj A 1082-1197 order
 Evidence NMR 2l85 A Reference
       Region 2l85 A 1081-1197 order
 Evidence NMR 2l84 A Reference
       Region 2l84 A 1081-1197 order
 Evidence X-RAY 5ktx A Reference
       Region 5ktx A 1085-1194 order
 Evidence X-RAY 5ktw C Reference
       Region 5ktw C 1085-1194 order
 Evidence X-RAY 5ktw B Reference
       Region 5ktw B 1085-1194 order
 Evidence X-RAY 5ktw A Reference
       Region 5ktw A 1085-1194 order
 Evidence X-RAY 5ktu B Reference
       Region 5ktu B 1082-1083 disorder
       Region 5ktu B 1084-1196 order
       Region 5ktu B 1197-1197 disorder
 Evidence X-RAY 5ktu A Reference
       Region 5ktu A 1082-1088 disorder
       Region 5ktu A 1089-1195 order
       Region 5ktu A 1196-1197 disorder
 Evidence X-RAY 5j0d A Reference
       Region 5j0d A 1081-1197 order
 Evidence X-RAY 5i89 A Reference
       Region 5i89 A 1082-1082 disorder
       Region 5i89 A 1083-1197 order
 Evidence X-RAY 5i86 B Reference
       Region 5i86 B 1082-1082 disorder
       Region 5i86 B 1083-1196 order
       Region 5i86 B 1197-1197 disorder
 Evidence X-RAY 5i86 A Reference
       Region 5i86 A 1082-1196 order
       Region 5i86 A 1197-1197 disorder
 Evidence X-RAY 5i83 A Reference
       Region 5i83 A 1082-1082 disorder
       Region 5i83 A 1083-1196 order
       Region 5i83 A 1197-1197 disorder
 Evidence X-RAY 5h85 A Reference
       Region 5h85 A 1081-1197 order
 Evidence X-RAY 5ep7 A Reference
       Region 5ep7 A 1081-1197 order
 Evidence X-RAY 5eic B Reference
       Region 5eic B 1081-1196 order
       Region 5eic B 1197-1197 disorder
 Evidence X-RAY 5eic A Reference
       Region 5eic A 1081-1083 disorder
       Region 5eic A 1084-1196 order
       Region 5eic A 1197-1197 disorder
 Evidence X-RAY 3dwy B Reference
       Region 3dwy B 1081-1084 disorder
       Region 3dwy B 1085-1196 order
       Region 3dwy B 1197-1197 disorder
 Evidence X-RAY 3dwy A Reference
       Region 3dwy A 1081-1083 disorder
       Region 3dwy A 1084-1197 order
 Evidence X-RAY 5dbm C Reference
       Region 5dbm C 1082-1197 order
 Evidence X-RAY 5dbm B Reference
       Region 5dbm B 1082-1083 disorder
       Region 5dbm B 1084-1196 order
       Region 5dbm B 1197-1197 disorder
 Evidence X-RAY 5dbm A Reference
       Region 5dbm A 1082-1082 disorder
       Region 5dbm A 1083-1196 order
       Region 5dbm A 1197-1197 disorder
 Evidence X-RAY 5cgp A Reference
       Region 5cgp A 1081-1082 disorder
       Region 5cgp A 1083-1197 order
 Evidence X-RAY 6ay5 A Reference
       Region 6ay5 A 1083-1197 order
 Evidence X-RAY 6ay3 B Reference
       Region 6ay3 B 1083-1197 order
 Evidence X-RAY 6ay3 A Reference
       Region 6ay3 A 1083-1197 order
 Evidence X-RAY 6axq D Reference
       Region 6axq D 1085-1196 order
 Evidence X-RAY 6axq C Reference
       Region 6axq C 1085-1196 order
 Evidence X-RAY 6axq B Reference
       Region 6axq B 1085-1196 order
 Evidence X-RAY 6axq A Reference
       Region 6axq A 1085-1196 order
 Evidence X-RAY 4a9k B Reference
       Region 4a9k B 1081-1084 disorder
       Region 4a9k B 1085-1196 order
       Region 4a9k B 1197-1197 disorder
 Evidence X-RAY 4a9k A Reference
       Region 4a9k A 1081-1082 disorder
       Region 4a9k A 1083-1197 order
Seq 1081-1312 Monomer :
 Evidence X-RAY 5i8g A Reference
       Region 5i8g A 1081-1241 order
       Region 5i8g A 1242-1249 disorder
       Region 5i8g A 1250-1312 order
 Evidence X-RAY 5i8b A Reference
       Region 5i8b A 1081-1241 order
       Region 5i8b A 1242-1249 disorder
       Region 5i8b A 1250-1312 order
Seq 1699-1751 Hetero dimer : IID00378Complex
 Evidence NMR 2n1a B Reference
       Region 2n1a B 1699-1751 order
       Region 2n1a B 1751-1751 high_rmsd
Seq 1763-1854 Hetero dimer : IID90003Complex
 Evidence NMR 2kje A Reference
       Region 2kje A 1763-1854 order
Seq 2065-2111 Hetero tetramer : IID00079Complex
 Evidence X-RAY 5jem H Reference
       Region 5jem H 2065-2106 order
       Region 5jem H 2107-2111 disorder
 Evidence X-RAY 5jem F Reference
       Region 5jem F 2065-2106 order
       Region 5jem F 2107-2111 disorder
Seq 2065-2111 Hetero tetramer : IID00079Complex
 Evidence X-RAY 5jem D Reference
       Region 5jem D 2065-2106 order
       Region 5jem D 2107-2111 disorder
 Evidence X-RAY 5jem C Reference
       Region 5jem C 2065-2106 order
       Region 5jem C 2107-2111 disorder
Seq 2065-2111 Hetero dimer : IID00079Complex
 Evidence X-RAY 1zoq D Reference
       Region 1zoq D 2065-2111 order
 Evidence X-RAY 1zoq C Reference
       Region 1zoq C 2065-2111 order
SeqProS possible 68-74 LXXLL motif Hetero tetramer : IID00041Complex
       Region 1rdt E 68-74 order
SeqProS possible 2065-2111 Same region of mouse homolog (P45481, 100% identity) is disordered in the free state. Hetero dimer : IID00079Complex
       Region 1zoq C 2065-2111 order
       Region 1zoq D 2065-2111 order
Seqphosphorylation
    121-121 Phosphoserine
    1030-1030 Phosphoserine
    1076-1076 Phosphoserine
    1382-1382 Phosphoserine; by IKKA
    1386-1386 Phosphoserine; by IKKA
    1763-1763 Phosphoserine
    2063-2063 Phosphoserine
    2076-2076 Phosphoserine
    2079-2079 Phosphoserine
    2351-2351 Phosphoserine
Seqacetylation
    2-2 N-acetylalanine
    657-657 N6-acetyllysine
    1014-1014 N6-acetyllysine
    1216-1216 N6-acetyllysine
    1583-1583 N6-acetyllysine
    1591-1591 N6-acetyllysine
    1592-1592 N6-acetyllysine
    1595-1595 N6-acetyllysine
    1597-1597 N6-acetyllysine
    1741-1741 N6-acetyllysine
    1744-1744 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-351,439-1080,1577-1608,1743-1765,1857-2189,2218-2442
Order 352-438,1081-1576,1609-1742,1766-1856,2190-2217
ProS 1-46,346-351,589-595,605-618,629-635,1577-1608,1743-1752,1857-1870,2068-2073,2084-2092,2432-2442
AlphaFold
Disorder 1-347,373-379,436-589,614-623,672-1081,1209-1210,1217-1218,1223-1223,1252-1259,1478-1479,1566-1614,1698-1706,1712-1716,1724-1725,1736-1737,1745-1769,1771-1771,1788-1789,1811-1815,1861-2081,2083-2083,2091-2091,2093-2095,2098-2197,2200-2200,2202-2442
Order 348-372,380-435,590-613,624-671,1082-1208,1211-1216,1219-1222,1224-1251,1260-1477,1480-1565,1615-1697,1707-1711,1717-1723,1726-1735,1738-1744,1770-1770,1772-1787,1790-1810,1816-1860,2082-2082,2084-2090,2092-2092,2096-2097,2198-2199,2201-2201
Pfam Hmmer
PF02135 348-432 5.1e-49
PF02172 587-667 2.4e-52
PF00439 1090-1180 5.4e-43
PF06001 1181-1241 2.2e-29
PF06010 1316-1553 3.2e-191
PF00569 1701-1742 4.8e-20
PF02135 1764-1843 1.2e-39
SEG 47-59 ,76-90 ,96-106 ,136-150 ,214-223 ,495-517 ,679-704 ,872-952 ,1044-1078 ,1550-1576 ,1583-1597 ,1846-1876 ,1883-1919 ,1941-1970 ,1981-1992 ,2017-2038 ,2076-2085 ,2112-2137 ,2146-2160 ,2196-2252 ,2257-2280 ,2287-2305 ,2344-2379
Function
Function in SwissProt
Acetylates histones, giving a specific tag for transcriptional activation (PubMed:24616510). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:9707565, PubMed:24207024, PubMed:28790157, PubMed:30540930). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493).
Biological Process
Diagram with PDB data
CREBBP/NCOA3Structure and dynamics conspire in the evolution of affinity between intrinsically disordered proteins
CREBBP/IRF3Crystal structure of human phosphorylated IRF-3 bound to CBP
See also
Diagram with PDB data
E1A_ADE05/CREBBPNMR structure of CBP TAZ2 and adenoviral E1A complex
TP53/EP300Structural Basis for the Regulation of p53 Function by p300
TP53/CREBBPNMR Structure of CBP Bromodomain in complex with p53 peptide
TP53/SETD7Crystal structure of a ternary complex of the methyltransferase SET9 (also known as SET7/9) with a P53 peptide and SAH
TP53/SMYD2Structure of SMYD2 in complex with p53 and SAH
TP53/CREBBPNMR Structure of CBP Bromodomain in complex with p53 peptide
CREB1/CRBBP/KMT2AAllosteric communication in the KIX domain proceeds through dynamic re-packing of the hydrophobic core
STAT1/CREBBPNMR structure of the CBP-TAZ2/STAT1-TAD complex
STAT2/CrebbpNMR structure of the CBP-TAZ1/STAT2-TAD complex
HIF1A/EP300NMR Structures of the HIF-1alpha CTAD/p300 CH1 Complex
CITED2/EP300Structural basis for negative regulation of hypoxia-inducible factor-1alpha by CITED2
NCOA3/CREBBPStructure and dynamics conspire in the evolution of affinity between intrinsically disordered proteins