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IID00061
 UniprotP63104
Protein14-3-3 protein zeta/delta
GeneYWHAZ
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
245
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-230 Hetero tetramer : IID00198Complex
 Evidence X-RAY 5m37 B Reference
       Region 5m37 B 1-1 disorder
       Region 5m37 B 2-70 order
       Region 5m37 B 71-72 disorder
       Region 5m37 B 73-230 order
 Evidence X-RAY 5m37 A Reference
       Region 5m37 A 1-230 order
Seq 1-230 Hetero tetramer : IID00522Complex
 Evidence X-RAY 5ewz B Reference
       Region 5ewz B 1-69 order
       Region 5ewz B 70-72 disorder
       Region 5ewz B 73-230 order
 Evidence X-RAY 5ewz A Reference
       Region 5ewz A 1-1 disorder
       Region 5ewz A 2-230 order
Seq 1-230 Hetero tetramer : Q99683
 Evidence X-RAY 6ejl B Reference
       Region 6ejl B 1-68 order
       Region 6ejl B 69-72 disorder
       Region 6ejl B 73-228 order
       Region 6ejl B 229-230 disorder
 Evidence X-RAY 6ejl A Reference
       Region 6ejl A 1-69 order
       Region 6ejl A 70-71 disorder
       Region 6ejl A 72-133 order
       Region 6ejl A 134-136 disorder
       Region 6ejl A 137-230 order
Seq 1-230 Hetero tetramer : Q07889
 Evidence X-RAY 6f08 J Reference
       Region 6f08 J 1-69 order
       Region 6f08 J 70-72 disorder
       Region 6f08 J 73-133 order
       Region 6f08 J 134-138 disorder
       Region 6f08 J 139-204 order
       Region 6f08 J 205-210 disorder
       Region 6f08 J 211-230 order
 Evidence X-RAY 6f08 I Reference
       Region 6f08 I 1-1 disorder
       Region 6f08 I 2-68 order
       Region 6f08 I 69-73 disorder
       Region 6f08 I 74-135 order
       Region 6f08 I 136-136 disorder
       Region 6f08 I 137-230 order
 Evidence X-RAY 6f08 B Reference
       Region 6f08 B 1-133 order
       Region 6f08 B 134-135 disorder
       Region 6f08 B 136-205 order
       Region 6f08 B 206-209 disorder
       Region 6f08 B 210-230 order
 Evidence X-RAY 6f08 A Reference
       Region 6f08 A 1-68 order
       Region 6f08 A 69-73 disorder
       Region 6f08 A 74-112 order
       Region 6f08 A 113-113 disorder
       Region 6f08 A 114-230 order
Seq 1-230 Hetero tetramer : IID00522Complex
 Evidence X-RAY 5exa B Reference
       Region 5exa B 1-230 order
 Evidence X-RAY 5exa A Reference
       Region 5exa A 1-1 disorder
       Region 5exa A 2-230 order
Seq 1-230 Hetero trimer : IID00540Complex
 Evidence X-RAY 5d3f B Reference
       Region 5d3f B 1-1 disorder
       Region 5d3f B 2-68 order
       Region 5d3f B 69-72 disorder
       Region 5d3f B 73-229 order
       Region 5d3f B 230-230 disorder
 Evidence X-RAY 5d3f A Reference
       Region 5d3f A 1-1 disorder
       Region 5d3f A 2-68 order
       Region 5d3f A 69-75 disorder
       Region 5d3f A 76-229 order
       Region 5d3f A 230-230 disorder
 Evidence X-RAY 5d2d B Reference
       Region 5d2d B 1-69 order
       Region 5d2d B 70-72 disorder
       Region 5d2d B 73-229 order
       Region 5d2d B 230-230 disorder
 Evidence X-RAY 5d2d A Reference
       Region 5d2d A 1-69 order
       Region 5d2d A 70-70 disorder
       Region 5d2d A 71-230 order
Seq 1-230 Hetero tetramer :
 Evidence X-RAY 2o02 A Reference
       Region 2o02 A 1-68 order
       Region 2o02 A 69-74 disorder
       Region 2o02 A 75-230 order
 Evidence X-RAY 2o02 B Reference
       Region 2o02 B 1-230 order
Seq 1-230 Homo dimer : IID00613Complex
 Evidence X-RAY 4zdr B Reference
       Region 4zdr B 1-70 order
       Region 4zdr B 71-72 disorder
       Region 4zdr B 73-208 order
       Region 4zdr B 209-209 disorder
       Region 4zdr B 210-230 order
 Evidence X-RAY 4zdr A Reference
       Region 4zdr A 1-70 order
       Region 4zdr A 71-72 disorder
       Region 4zdr A 73-230 order
Seq 1-230 Hetero tetramer : Q93SQ3
 Evidence X-RAY 4n84 B Reference
       Region 4n84 B 1-70 order
       Region 4n84 B 71-72 disorder
       Region 4n84 B 73-204 order
       Region 4n84 B 205-205 disorder
       Region 4n84 B 207-207 disorder
       Region 4n84 B 208-230 order
 Evidence X-RAY 4n84 A Reference
       Region 4n84 A 1-205 order
       Region 4n84 A 207-209 disorder
       Region 4n84 A 210-230 order
 Evidence X-RAY 4n7y B Reference
       Region 4n7y B 1-70 order
       Region 4n7y B 71-72 disorder
       Region 4n7y B 73-203 order
       Region 4n7y B 204-205 disorder
       Region 4n7y B 206-207 order
       Region 4n7y B 208-210 disorder
       Region 4n7y B 211-230 order
 Evidence X-RAY 4n7y A Reference
       Region 4n7y A 1-230 order
 Evidence X-RAY 4n7g A Reference
       Region 4n7g A 1-203 order
       Region 4n7g A 204-204 disorder
       Region 4n7g A 205-230 order
 Evidence X-RAY 5j31 B Reference
       Region 5j31 B 1-206 order
       Region 5j31 B 207-207 disorder
       Region 5j31 B 208-230 order
 Evidence X-RAY 5j31 A Reference
       Region 5j31 A 1-206 order
       Region 5j31 A 207-207 disorder
       Region 5j31 A 208-230 order
Seq 1-230 Hetero tetramer : P40818
 Evidence X-RAY 6f09 R Reference
       Region 6f09 R 1-1 disorder
       Region 6f09 R 2-70 order
       Region 6f09 R 71-71 disorder
       Region 6f09 R 72-201 order
       Region 6f09 R 202-202 disorder
       Region 6f09 R 203-204 order
       Region 6f09 R 205-206 disorder
       Region 6f09 R 207-230 order
 Evidence X-RAY 6f09 Q Reference
       Region 6f09 Q 1-1 disorder
       Region 6f09 Q 2-70 order
       Region 6f09 Q 71-71 disorder
       Region 6f09 Q 72-73 order
       Region 6f09 Q 74-75 disorder
       Region 6f09 Q 76-229 order
       Region 6f09 Q 230-230 disorder
 Evidence X-RAY 6f09 S Reference
       Region 6f09 S 1-1 disorder
       Region 6f09 S 2-135 order
       Region 6f09 S 136-136 disorder
       Region 6f09 S 137-230 order
 Evidence X-RAY 6f09 P Reference
       Region 6f09 P 1-1 disorder
       Region 6f09 P 2-33 order
       Region 6f09 P 34-34 disorder
       Region 6f09 P 35-134 order
       Region 6f09 P 135-135 disorder
       Region 6f09 P 136-230 order
Seq 1-230 Hetero octamer : Q96RR4
 Evidence X-RAY 6eww D Reference
       Region 6eww D 1-1 disorder
       Region 6eww D 2-67 order
       Region 6eww D 68-76 disorder
       Region 6eww D 77-229 order
       Region 6eww D 230-230 disorder
 Evidence X-RAY 6eww C Reference
       Region 6eww C 1-69 order
       Region 6eww C 70-74 disorder
       Region 6eww C 75-133 order
       Region 6eww C 134-137 disorder
       Region 6eww C 138-230 order
 Evidence X-RAY 6eww B Reference
       Region 6eww B 1-68 order
       Region 6eww B 69-72 disorder
       Region 6eww B 73-204 order
       Region 6eww B 205-207 disorder
       Region 6eww B 208-229 order
       Region 6eww B 230-230 disorder
 Evidence X-RAY 6eww A Reference
       Region 6eww A 1-69 order
       Region 6eww A 70-73 disorder
       Region 6eww A 74-202 order
       Region 6eww A 203-211 disorder
       Region 6eww A 212-229 order
       Region 6eww A 230-230 disorder
Seq 1-230 Hetero tetramer : Q9UBF8
 Evidence X-RAY 5nas B Reference
       Region 5nas B 1-230 order
 Evidence X-RAY 5nas A Reference
       Region 5nas A 1-230 order
Seq 1-230 Hetero trimer : IID00292Complex
 Evidence X-RAY 4ihl B Reference
       Region 4ihl B 1-70 order
       Region 4ihl B 71-72 disorder
       Region 4ihl B 73-135 order
       Region 4ihl B 136-136 disorder
       Region 4ihl B 137-230 order
 Evidence X-RAY 4ihl A Reference
       Region 4ihl A 1-230 order
 Evidence X-RAY 4fj3 B Reference
       Region 4fj3 B 1-1 disorder
       Region 4fj3 B 2-69 order
       Region 4fj3 B 70-71 disorder
       Region 4fj3 B 72-133 order
       Region 4fj3 B 134-136 disorder
       Region 4fj3 B 137-203 order
       Region 4fj3 B 204-205 disorder
       Region 4fj3 B 206-230 order
 Evidence X-RAY 4fj3 A Reference
       Region 4fj3 A 1-1 disorder
       Region 4fj3 A 2-69 order
       Region 4fj3 A 70-72 disorder
       Region 4fj3 A 73-203 order
       Region 4fj3 A 204-209 disorder
       Region 4fj3 A 210-230 order
Seq 1-245 Hetero dimer : IID00062Complex
 Evidence X-RAY 2c1n B Reference
       Region 2c1n B 1-133 order
       Region 2c1n B 134-138 disorder
       Region 2c1n B 139-230 order
       Region 2c1n B 231-245 disorder
 Evidence X-RAY 2c1n A Reference
       Region 2c1n A 1-133 order
       Region 2c1n A 134-138 disorder
       Region 2c1n A 139-230 order
       Region 2c1n A 231-245 disorder
Seq 1-245 Hetero tetramer : IID50013Complex
 Evidence X-RAY 1ib1 D Reference
       Region 1ib1 D 1-1 disorder
       Region 1ib1 D 2-228 order
       Region 1ib1 D 229-245 disorder
 Evidence X-RAY 1ib1 C Reference
       Region 1ib1 C 1-1 disorder
       Region 1ib1 C 2-228 order
       Region 1ib1 C 229-245 disorder
Seq 1-245 Hetero dimer : IID00615Complex
 Evidence X-RAY 4hkc A Reference
       Region 4hkc A 1-1 disorder
       Region 4hkc A 2-230 order
       Region 4hkc A 231-245 disorder
Seq 1-245 Homo dimer :
 Evidence X-RAY 3rdh C Reference
       Region 3rdh C 1-230 order
       Region 3rdh C 231-245 disorder
 Evidence X-RAY 3rdh B Reference
       Region 3rdh B 1-230 order
       Region 3rdh B 231-245 disorder
 Evidence X-RAY 3rdh D Reference
       Region 3rdh D 1-230 order
       Region 3rdh D 231-245 disorder
 Evidence X-RAY 3rdh A Reference
       Region 3rdh A 1-230 order
       Region 3rdh A 231-245 disorder
 Evidence X-RAY 5jm4 B Reference
       Region 5jm4 B 1-207 order
       Region 5jm4 B 208-208 disorder
       Region 5jm4 B 209-229 order
 Evidence X-RAY 5jm4 A Reference
       Region 5jm4 A 1-1 disorder
       Region 5jm4 A 2-70 order
       Region 5jm4 A 71-71 disorder
       Region 5jm4 A 72-229 order
Seq 1-245 Hetero tetramer : P0DOJ7
 Evidence X-RAY 1qjb A Reference
       Region 1qjb A 1-68 order
       Region 1qjb A 69-72 disorder
       Region 1qjb A 73-232 order
       Region 1qjb A 233-245 disorder
 Evidence X-RAY 1qjb B Reference
       Region 1qjb B 1-232 order
       Region 1qjb B 233-245 disorder
Seq 1-245 Hetero tetramer :
 Evidence X-RAY 1qja A Reference
       Region 1qja A 1-66 order
       Region 1qja A 67-76 disorder
       Region 1qja A 77-133 order
       Region 1qja A 134-136 disorder
       Region 1qja A 137-230 order
       Region 1qja A 231-245 disorder
 Evidence X-RAY 1qja B Reference
       Region 1qja B 1-133 order
       Region 1qja B 134-137 disorder
       Region 1qja B 138-229 order
       Region 1qja B 230-245 disorder
Seq 1-245 Hetero dimer : Q5SZL8
 Evidence X-RAY 5ulo B Reference
       Region 5ulo B 1-134 order
       Region 5ulo B 135-135 disorder
       Region 5ulo B 136-229 order
       Region 5ulo B 230-245 disorder
 Evidence X-RAY 5ulo A Reference
       Region 5ulo A 1-68 order
       Region 5ulo A 69-71 disorder
       Region 5ulo A 72-134 order
       Region 5ulo A 135-135 disorder
       Region 5ulo A 136-229 order
       Region 5ulo A 230-245 disorder
Seq 1-245 Hetero tetramer : IID50013Complex
 Evidence X-RAY 1ib1 B Reference
       Region 1ib1 B 1-1 disorder
       Region 1ib1 B 2-228 order
       Region 1ib1 B 229-245 disorder
 Evidence X-RAY 1ib1 A Reference
       Region 1ib1 A 1-1 disorder
       Region 1ib1 A 2-228 order
       Region 1ib1 A 229-245 disorder
Seq 1-245 Hetero tetramer : IID00613Complex
 Evidence X-RAY 5wxn B Reference
       Region 5wxn B 1-230 order
       Region 5wxn B 231-245 disorder
 Evidence X-RAY 5wxn A Reference
       Region 5wxn A 1-230 order
       Region 5wxn A 231-245 disorder
Seq 1-245 Hetero trimer : IID00066Complex
 Evidence X-RAY 2wh0 D Reference
       Region 2wh0 D 1-1 disorder
       Region 2wh0 D 2-66 order
       Region 2wh0 D 67-71 disorder
       Region 2wh0 D 72-204 order
       Region 2wh0 D 205-205 disorder
       Region 2wh0 D 206-229 order
       Region 2wh0 D 230-245 disorder
 Evidence X-RAY 2wh0 C Reference
       Region 2wh0 C 1-3 disorder
       Region 2wh0 C 4-229 order
       Region 2wh0 C 230-245 disorder
 Evidence X-RAY 2wh0 B Reference
       Region 2wh0 B 1-1 disorder
       Region 2wh0 B 2-228 order
       Region 2wh0 B 229-245 disorder
 Evidence X-RAY 2wh0 A Reference
       Region 2wh0 A 1-1 disorder
       Region 2wh0 A 2-70 order
       Region 2wh0 A 71-71 disorder
       Region 2wh0 A 72-203 order
       Region 2wh0 A 204-209 disorder
       Region 2wh0 A 210-229 order
       Region 2wh0 A 230-245 disorder
Seq 1-245 Hetero dimer : P61587
 Evidence X-RAY 4bg6 B Reference
       Region 4bg6 B 1-1 disorder
       Region 4bg6 B 2-230 order
       Region 4bg6 B 231-245 disorder
 Evidence X-RAY 4bg6 A Reference
       Region 4bg6 A 1-69 order
       Region 4bg6 A 70-72 disorder
       Region 4bg6 A 73-231 order
       Region 4bg6 A 232-245 disorder
Seq 1-245 Hetero tetramer : IID00292Complex
 Evidence X-RAY 3nkx B Reference
       Region 3nkx B 1-70 order
       Region 3nkx B 71-72 disorder
       Region 3nkx B 73-230 order
       Region 3nkx B 231-245 disorder
 Evidence X-RAY 3nkx A Reference
       Region 3nkx A 1-1 disorder
       Region 3nkx A 2-230 order
       Region 3nkx A 231-245 disorder
 Evidence X-RAY 3cu8 B Reference
       Region 3cu8 B 1-70 order
       Region 3cu8 B 71-72 disorder
       Region 3cu8 B 73-230 order
       Region 3cu8 B 231-245 disorder
 Evidence X-RAY 3cu8 A Reference
       Region 3cu8 A 1-1 disorder
       Region 3cu8 A 2-230 order
       Region 3cu8 A 231-245 disorder
Seq 1-245 Hetero tetramer : IID00062Complex
 Evidence X-RAY 2c1j B Reference
       Region 2c1j B 1-230 order
       Region 2c1j B 231-245 disorder
 Evidence X-RAY 2c1j A Reference
       Region 2c1j A 1-230 order
       Region 2c1j A 231-245 disorder
Seq 1-245 Hetero tetramer : Q9Y3M2
 Evidence X-RAY 4wrq B Reference
       Region 4wrq B 1-229 order
       Region 4wrq B 230-245 disorder
 Evidence X-RAY 4wrq A Reference
       Region 4wrq A 1-66 order
       Region 4wrq A 67-76 disorder
       Region 4wrq A 77-230 order
       Region 4wrq A 231-245 disorder
Seq 2-230 Hetero trimer : IID00198Complex
 Evidence X-RAY 5m36 B Reference
       Region 5m36 B 2-67 order
       Region 5m36 B 68-70 disorder
       Region 5m36 B 71-204 order
       Region 5m36 B 205-210 disorder
       Region 5m36 B 211-229 order
       Region 5m36 B 230-230 disorder
 Evidence X-RAY 5m36 A Reference
       Region 5m36 A 2-69 order
       Region 5m36 A 70-72 disorder
       Region 5m36 A 73-204 order
       Region 5m36 A 205-209 disorder
       Region 5m36 A 210-230 order
Seq 2-230 Hetero tetramer : IID00198Complex
 Evidence X-RAY 5m35 B Reference
       Region 5m35 B 2-70 order
       Region 5m35 B 71-72 disorder
       Region 5m35 B 73-204 order
       Region 5m35 B 205-208 disorder
       Region 5m35 B 209-230 order
 Evidence X-RAY 5m35 A Reference
       Region 5m35 A 2-204 order
       Region 5m35 A 205-205 disorder
       Region 5m35 A 206-230 order
Seqphosphorylation
    232-232 Phosphothreonine; by CK1
    58-58 Phosphoserine; by PKA and PKB/AKT1
    184-184 Phosphoserine; by MAPK8
    207-207 Phosphoserine
    210-210 Phosphoserine
Seqacetylation
    1-1 N-acetylmethionine
    3-3 N6-acetyllysine
    68-68 N6-acetyllysine
 
Prediction
NeProc
Disorder 233-245
Order 1-232
ProS 233-237,242-245
AlphaFold
Disorder 233-245
Order 1-232
Pfam Hmmer
PF00244 3-236 3.2e-151
SEG 234-244
Function
Function in SwissProt
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity).
Biological Process
See also
Diagram with PDB data
RAF1/YWHAZHuman 14-3-3 isoform zeta in complex with a diphoyphorylated C-RAF peptide and Cotylenin A
CFTR/YWHAZCrystal structure of human 14-3-3 zeta in complex with CFTR R-domain peptide pS753-pS768
ITGA4/YWHAZ14-3-3-zeta in complex with S1011 phosphorylated integrin alpha-4 peptide
H3C1/YWHAZMolecular basis for the recognition of phosphorylated and phosphoacetylated histone H3 by 14-3-3
PRKCE/YWHAZRecognition of an intrachain tandem 14-3-3 binding site within protein kinase C epsilon
STK11/YWHAZStructure of the LKB1 and 14-3-3 complex
AANAT/YWHAZCRYSTAL STRUCTURE OF THE 14-3-3 ZETA:SEROTONIN N-ACETYLTRANSFERASE COMPLEX
GAB2/GRB2Grb2 SH3C (3)